CAS 500271-63-6

2-amino-1-(4-fluorobenzyl)-N-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide

Fórmula: C₂₃H₂₄FN₅O

InChI: InChI=1S/C23H24FN5O/c1-2-3-6-13-26-23(30)19-20-22(28-18-8-5-4-7-17(18)27-20)29(21(19)25)14-15-9-11-16(24)12-10-15/h4-5,7-12H,2-3,6,13-14,25H2,1H3,(H,26,30)

Clave InChI: FYNPHMNXVLLDAS-UHFFFAOYSA-N

SMILES: CCCCCNC(=O)C1=C(N(C2=NC3=CC=CC=C3N=C12)CC4=CC=C(C=C4)F)N

Sinónimos:

• 2-APQC
• 2-amino-1-(4-fluorobenzyl)-N-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide
• 1H-Pyrrolo[2,3-b]quinoxaline-3-carboxamide, 2-amino-1-[(4-fluorophenyl)methyl]-N-pentyl-

2-Amino-1-[(4-fluorophenyl)methyl]-N-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide

CAS: 500271-63-6

Fórmula: C₂₃H₂₄FN₅O

Pureza: 95%

Forma y color: Solid

Peso molecular: 405.4680

Ref: IN-DA02QOEI

2-APQC

CAS: 500271-63-6

2-APQC is a selective, orally active Sirtuin-3 (SIRT3) agonist (Kd=2.756 μM) that modulates mitochondrial homeostasis. It attenuates ISO-induced myocardial hypertrophy and fibrosis in vivo and in vitro, making it suitable for heart failure research. 2-APQC inhibits mTOR-p70S6K, JNK, TGF-β/Smad3, and ROS-p38MAPK pathways while activating PYCR1 and AMPK-Parkin, thereby suppressing necrosis and mitigating mitochondrial oxidative damage.

Fórmula: C₂₃H₂₄FN₅O

Pureza: 99.88%

Forma y color: White Solid

Peso molecular: 405.468

Ref: TM-T88667