CAS 53-85-0

5,6-Dicloro-1-(β-D-ribofuranosil)benzimidazol

Descripción:

5,6-Dicloro-1-(β-D-ribofuranosil)benzimidazol es un compuesto químico caracterizado por su estructura, que incluye un núcleo de benzimidazol sustituido con dos átomos de cloro en las posiciones 5 y 6 y un grupo β-D-ribofuranosilo en la posición 1. Este compuesto es conocido por su papel como agente antiviral, particularmente en el contexto de la inhibición de la replicación viral. Exhibe propiedades típicas de los derivados de benzimidazol, como interacciones potenciales con ácidos nucleicos y enzimas. La presencia del moiety ribofuranosilo mejora su actividad biológica al facilitar la incorporación en estructuras de ácidos nucleicos. Su peso molecular y características de solubilidad pueden variar según el disolvente utilizado, pero generalmente es soluble en disolventes polares. El número CAS del compuesto, 53-85-0, es un identificador único que ayuda en su clasificación y recuperación en bases de datos químicas. En general, 5,6-Dicloro-1-(β-D-ribofuranosil)benzimidazol es significativo en la química medicinal y la investigación virológica.

Fórmula: C₁₂H₁₂Cl₂N₂O₄

InChI: InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1

Clave InChI: InChIKey=XHSQDZXAVJRBMX-DDHJBXDOSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=CC(Cl)=C(Cl)C3)O[C@H](CO)[C@H]1O

Sinónimos:

• 1-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-5,6-dichlorobenzimidazole
• 1H-Benzimidazole, 5,6-dichloro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 5,6-Dichloro-1-(β-<span class="text-smallcaps">D</span>-ribofuranosyl)benzimidazole
• 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole
• 5,6-Dichloro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
• 5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside
• 5,6-Dichlorobenzimidazole 1-β-<span class="text-smallcaps">D</span>-ribofuranoside
• 5,6-Dichlororibofuranosylbenzimidazole
• 5,6-dichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole
• 5,6-dichloro-1-[(2xi)-beta-D-threo-pentofuranosyl]-1H-benzimidazole
• 5,6-dichloro-1-pentofuranosyl-1H-benzimidazole
• Benzimidazole, 5,6-dichloro-1-<span class="text-smallcaps">D</span>-ribofuranosyl-
• Benzimidazole, 5,6-dichloro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• NSC 401575
• Nqz-002
• 5,6-Dichloro-1-β-D-ribofuranosyl-1H-benzimidazole
• 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole
• 1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl-
• Benzimidazole, 5,6-dichloro-1-D-ribofuranosyl-

5,6-Dichlorobenzimidazole 1-beta-D-Ribofuranoside

CAS: 53-85-0

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Pureza: >98.0%(HPLC)(qNMR)

Forma y color: White to Almost white powder to crystal

Peso molecular: 319.14

Ref: 3B-D4292

5,6-Dichlorobenzimidazole riboside, 98%

CAS: 53-85-0

Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases. This The

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Pureza: 98%

Forma y color: White to pale cream, Powder

Peso molecular: 319.14

Ref: 02-J64870

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

CAS: 53-85-0

5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Forma y color: Solid

Peso molecular: 319.14067

Ref: 54-BIA8417

DRB

CAS: 53-85-0

DRB

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Pureza: 99.5%

Peso molecular: 319.14

Ref: 54-BUP11257

5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside

CAS: 53-85-0

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Peso molecular: 319.14

Ref: 7W-GN4594

(2R,3R,4S,5R)-2-(5,6-Dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

CAS: 53-85-0

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 319.1407

Ref: IN-DA00I9GQ

DRB

CAS: 53-85-0

DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)

Fórmula: C₁₂H₁₀Cl₂N₂O

Pureza: 99.46% - 99.83%

Forma y color: White To Off-White Crystalline Solid

Peso molecular: 269.127

Ref: TM-T7789

5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside

CAS: 53-85-0

5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside is a chemical compound that has been shown to be neurotoxic in vitro. It has significant cytotoxicity against human leukemia cells (HL60) and induces neuronal death. This drug also inhibits the production of neurotrophic factors, which are vital for the normal development of neurons. 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside inhibits transcriptional regulation of genes that encode for receptors and enzymes. The compound is chemically stable and does not degrade easily by hydrolysis or oxidation. It can bind to polymerase chain reaction (PCR) primers and inhibit DNA synthesis. 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside also affects cell nuclei by inhibiting DNA synthesis and enzyme activities.

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 319.15 g/mol

Ref: 3D-ND06701

5,6-Dichlorobenzimidazole riboside

CAS: 53-85-0

Pureza: 98%

Peso molecular: 318.017

Ref: 10-F869536

DRB

CAS: 53-85-0

(2R,3R,4S,5R)-2-(5,6-Dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Pureza: 98%

Peso molecular: 319.14

Ref: IN-DG305852

5,6-Dichloropurine-1-Beta-D-ribofuanosyl-H-benzimidazole

Producto controlado

CAS: 53-85-0

Applications An inhibitor of RNA synthesis (causes premature termination of transcription).
References Braedlye, J. and Sporns, O.: Brain Res., 815, 140 (1999), Ljungman, M., et al.: Oncogene, 18, 583 (1999), Roele, R.H., et al.: Oncogene, 18, 5765 (1999)

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Forma y color: Neat

Peso molecular: 319.14

Ref: TR-D435820

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

CAS: 53-85-0

Fórmula: C₁₂H₁₂Cl₂N₂O₄

Peso molecular: 319.14

Ref: ST-EA-CP-A88075