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CAS 53123-88-9

:

Rapamicina

Descripción:
Rapamicina, también conocido como sirolimus, es un compuesto macrólido con el número CAS 53123-88-9. Es producido por la bacteria *Streptomyces hygroscopicus* y es conocido principalmente por sus propiedades inmunosupresoras, lo que lo hace valioso en el trasplante de órganos para prevenir el rechazo. Rapamicina funciona inhibiendo el objetivo mamífero de Rapamicina (mTOR), un regulador clave del crecimiento celular, la proliferación y la supervivencia. Esta inhibición conduce a una reducción en la activación y proliferación de células T. Además de sus efectos inmunosupresores, Rapamicina ha atraído atención por sus potenciales propiedades anticancerígenas y su papel en la promoción de la longevidad en varios organismos modelo. El compuesto se administra típicamente por vía oral y tiene una vida media relativamente larga, lo que permite efectos terapéuticos sostenidos. Sin embargo, puede tener efectos secundarios, incluyendo un mayor riesgo de infecciones, alteraciones metabólicas y potencial toxicidad pulmonar. Debido a su compleja farmacocinética, a menudo es necesario monitorear los niveles en sangre para optimizar la dosificación y minimizar los efectos adversos.
Fórmula:C33H31NO2
InChI:InChI=1/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12-,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38?,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
Clave InChI:InChIKey=QFJCIRLUMZQUOT-HPLJOQBZSA-N
SMILES:O=C1N2[C@](C(=O)O[C@]([C@@H](C[C@H]3C[C@@H](OC)[C@H](O)CC3)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)\[C@@H](OC)C[C@]4(O[C@@](O)(C1=O)[C@H](C)CC4)[H])[H])(CCCC2)[H]
Sinónimos:
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • 14S-Rapamycin
  • 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*S*1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))-
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, [3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-
  • 6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • Antibiotic AY 22989
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productos por página.Se han encontrado 25 productos.
  • Rapamycin

    CAS:
    Fórmula:C51H79NO13
    Pureza:>95.0%(HPLC)
    Forma y color:White to Almost white powder to crystal
    Peso molecular:914.19

    Ref: 3B-R0097

    25mg
    75,00€
  • Rapamycin, 98+%

    CAS:
    Rapamycin, 53123-88-9, also known as Sirolimus, is a macrolide which exhibits antitumor and immunosuppressive activity. Learn more at Thermo Fisher Scientific.
    Fórmula:C51H79NO13
    Pureza:98+%
    Forma y color:White to cream to yellow, Powder or crystals or crystalline powder
    Peso molecular:914.19

    Ref: 02-J62473

    50mg
    187,00€
    100mg
    242,00€
    200mg
    302,00€
  • Rapamycin

    CAS:

    M02444 - Rapamycin

    Fórmula:C51H79NO13
    Pureza:98%
    Forma y color:Solid, Crystalline Powder or Granules or Powder
    Peso molecular:914.187

    Ref: 10-M02444

    10mg
    24,00€
    50mg
    31,00€
    100mg
    34,00€
    500mg
    91,00€
    250mg
    96,00€
    1g
    102,00€
    5g
    408,00€
  • Sirolimus

    CAS:
    Antibiotics nesoi
    Fórmula:C51H79NO13
    Forma y color:Off-White White Powder
    Peso molecular:913.55514
  • Rapamycin

    CAS:
    Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.
    Fórmula:C51H79NO13
    Pureza:97.08% - 99.97%
    Forma y color:White Solid
    Peso molecular:914.17

    Ref: TM-T1537

    10mg
    34,00€
    25mg
    46,00€
    1mL*10mM (DMSO)
    48,00€
    50mg
    50,00€
    100mg
    65,00€
    200mg
    101,00€
    500mg
    178,00€
    1g
    268,00€
  • Ref: IN-DA0035KC

    1mg
    A consultar
    5mg
    A consultar
    25g
    A consultar
    10mg
    25,00€
    50mg
    28,00€
    100mg
    28,00€
    250mg
    46,00€
    500mg
    64,00€
    1g
    91,00€
    5g
    215,00€
    10g
    520,00€
    50g
    1.172,00€
    100g
    2.101,00€
    250g
    4.725,00€
  • Rapamycin (Sirolimus, Everolimus EP Impurity A)

    CAS:
    Fórmula:C51H79NO13
    Forma y color:White To Off-White Solid
    Peso molecular:914.19

    Ref: 4Z-R-182

    5mg
    A consultar
    100mg
    A consultar
    10mg
    343,00€
    25mg
    436,00€
    50mg
    623,00€
  • Rapamycin

    CAS:
    Rapamycin
    Fórmula:C51H79NO13
    Pureza:≥95%
    Forma y color:Solid
    Peso molecular:914.17

    Ref: 54-BUP17166

    10mg
    53,00€
    25mg
    64,00€
    50mg
    76,00€
    100mg
    96,00€
    200mg
    163,00€
    500mg
    273,00€
  • Rapamycin

    CAS:
    Fórmula:C51H79NO13
    Pureza:98.0 - 102.0 % (anhydrous basis)
    Forma y color:White to yellow crystalline powder
    Peso molecular:914.17

    Ref: 7W-GA7417

    5mg
    35,00€
    25mg
    83,00€
    50mg
    155,00€
    100mg
    255,00€
  • Rapamycin from Streptomyces hygroscopicus

    CAS:
    Rapamycin from Streptomyces hygroscopicus
    Fórmula:C51H79NO13
    Pureza:By hplc: 99.14% (Typical Value in Batch COA)
    Forma y color:White Solid-Powder
    Peso molecular:914.17186

    Ref: 54-BIR8101

    500mg
    127,00€
    1g
    211,00€
    5g
    738,00€
  • Rapamycin

    CAS:
    Fórmula:C51H79NO13
    Pureza:95%~99%
    Peso molecular:914.187

    Ref: BP-BP1196

    ne
    A consultar
  • Rapamycin (Standard)

    CAS:
    Rapamycin (Standard) is a reference standard for research and analysis in studies involving Rapamycin. Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
    Fórmula:C51H79NO13
    Forma y color:Solid
    Peso molecular:914.17

    Ref: TM-TMSM-3400

    50mg
    203,00€
  • Rapamycin

    CAS:
    (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
    Fórmula:C51H79NO13
    Pureza:98%
    Peso molecular:914.17
  • Rapamycin

    CAS:
    Fórmula:C51H79NO13
    Peso molecular:914.19

    Ref: ST-EA-CP-R26000

    10mg
    A consultar
    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • Everolimus EP Impurity A

    CAS:
    Fórmula:C51H79NO13
    Peso molecular:914.2

    Ref: ST-EA-CP-E33001

    10mg
    A consultar
    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar
  • Rapamycin (>85%)

    CAS:

    Applications A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It has shown its efficacy against neurodegenerative diseases including Alzheimer's and Parkinson's.
    References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),

    Fórmula:C51H79NO13
    Pureza:>85%
    Forma y color:Neat
    Peso molecular:914.17

    Ref: TR-R124000

    5mg
    116,00€
    50mg
    437,00€
    100mg
    789,00€
  • Rapamycin-13C,d3 (contains d0) Technical Grade

    Producto controlado
    CAS:

    Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0.
    References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),

    Fórmula:C50CH76D3NO13
    Forma y color:Neat
    Peso molecular:918.18

    Ref: TR-R124003

    1mg
    633,00€
    5mg
    2.407,00€
    10mg
    4.548,00€
  • Rapamycin - Bio-X ™

    CAS:

    Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.

    Fórmula:C51H79NO13
    Pureza:Min. 95%
    Forma y color:Powder
    Peso molecular:914.17 g/mol

    Ref: 3D-BR164324

    10mg
    186,00€
  • Rapamycin

    CAS:
    Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.
    Fórmula:C51H79NO13
    Pureza:Min. 95 Area-%
    Forma y color:White Powder
    Peso molecular:914.17 g/mol

    Ref: 3D-AE27685

    250mg
    398,00€
    500mg
    566,00€
    1g
    737,00€
    2g
    1.055,00€
    5g
    1.989,00€
  • Ref: BE-MU-7122YA-1000

    1ml
    62,00€