CAS 54-42-2

5-Iodo-2'-desoxiuridina

Descripción:

5-Iodo-2'-desoxiuridina (IDU) es un análogo de nucleósido de la timidina, caracterizado por la presencia de un átomo de yodo en la posición 5 del anillo de pirimidina. Se utiliza principalmente en la investigación antiviral y como un posible agente terapéutico en el tratamiento del cáncer debido a su capacidad para interferir con la síntesis de ADN. El IDU es un polvo cristalino blanco a blanco sucio que es soluble en agua y presenta un perfil de estabilidad moderado en condiciones fisiológicas. Su fórmula molecular es C₁₃H₁₂I N₃O₅, y tiene un peso molecular que refleja su estructura compleja. Se sabe que el compuesto inhibe la replicación viral, particularmente en el contexto del virus del herpes simple, y también se estudia por sus efectos en los procesos celulares. El IDU puede incorporarse al ADN durante la replicación, lo que lleva a mutaciones y, en última instancia, a la muerte celular, que es un mecanismo explotado en la terapia del cáncer. Se requieren precauciones de seguridad y manejo debido a sus posibles efectos biológicos, y debe utilizarse en entornos de laboratorio controlados.

Fórmula: C₉H₁₁IN₂O₅

InChI: InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

Clave InChI: InChIKey=XQFRJNBWHJMXHO-RRKCRQDMSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(I)C(=O)N1

Sinónimos:

• 1-(2-Dehydroxy-β-D-ribofuranosyl)-5-iodouracil
• 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-iodouracil
• 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil
• 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
• 1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
• 1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]-5-iodopyrimidine-2,4(1H,3H)-dione
• 2'-Desoxy-5-iodouridine
• 2-Deoxy-5-iodouridine
• 5-Iodo-2'-Deoxy-D-Uridine
• 5-Iodo-2'-desoxyuridine
• 5-Iodo-deoxyuridine
• 5-Iododeoxyuridine
• 5-Iodouracil deoxyriboside
• 5Iudr
• Allergan 211
• Dendrid
• Emanil
• Herpe-Gel
• Herpesil
• Herpidu
• Herplex
• IDU
• Idexur
• Idoxene
• Idoxuridin
• Idoxuridina
• Idoxuridine
• Idu Oculos
• Iducher
• Idulea
• Idur
• Iduridin
• Iododeoxyuridine
• Iudr
• Joddeoxiuridin
• Kerecid
• Nsc 39661
• Ophthalmadine
• Skf 14287
• Stoxil
• Stoxip
• Synmiol
• Uridine, 2'-deoxy-5-iodo-
• Virudox

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Fórmula: C₉H₁₁IN₂O₅

Pureza: >99.0%(T)

Forma y color: White to Almost white powder to crystal

Peso molecular: 354.10

Ref: 3B-I0258

(+)-5-Iodo-2'-deoxyuridine, 98%

CAS: 54-42-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₉H₁₁IN₂O₅

Pureza: 98%

Forma y color: White to pale cream, Crystals or powder or crystalline powder

Peso molecular: 354.10

Ref: 02-A11542

IDOXURIDINE CRS

CAS: 54-42-2

IDOXURIDINE CRS

Fórmula: C₉H₁₁IN₂O₅

Forma y color: Powder

Peso molecular: 354.0985

Ref: 41-I0050000

Idoxuridine

CAS: 54-42-2

Idoxuridine

Fórmula: C₉H₁₁IN₂O₅

Pureza: 99.9%

Forma y color: White

Peso molecular: 353.97127

Ref: 47-202

Idoxuridine

CAS: 54-42-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₉H₁₁IN₂O₅

Forma y color: White Crystalline Powder

Peso molecular: 353.97127

Ref: 45-1336001

Idoxuridine

CAS: 54-42-2

Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.

Fórmula: C₉H₁₁IN₂O₅

Pureza: 99.45% - 99.62%

Forma y color: Crystals From Water Triclinic Solid

Peso molecular: 354.1

Ref: TM-T0863

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Fórmula: C₉H₁₁IN₂O₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 354.0985

Ref: IN-DA003AAB

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

5-Iodo-2'-deoxyuridine

Pureza: 99%

Peso molecular: 354.10g/mol

Ref: 54-OR72935

Idoxuridine

CAS: 54-42-2

Idoxuridine

Pureza: ≥98%

Peso molecular: 354.1g/mol

Ref: 54-BUP18492

5-Iodo-2''-deoxyuridine

CAS: 54-42-2

Fórmula: C₉H₁₁IN₂O₅

Pureza: ≥ 98.5%

Forma y color: White to off-white crystalline powder

Peso molecular: 354.10

Ref: 7W-GP1769

Idoxuridine

Producto controlado

CAS: 54-42-2

Fórmula: C₉H₁₁IN₂O₅

Forma y color: Neat

Peso molecular: 354.10

Ref: 86-MM0791.00

Idoxuridine

CAS: 54-42-2

Fórmula: C₉H₁₁IN₂O₅

Forma y color: Neat

Peso molecular: 354.10

Ref: 04-C14278800

Idoxuridine RS

CAS: 54-42-2

Forma y color: Colorless Or White

Ref: 2K-1015000021

Idoxuridine

Producto controlado

CAS: 54-42-2

Applications Idoxuridine is an antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents.
References Chang, C., et al.: J. Biol. Chem., 267, 22414 (1992), Pressacco, J., et al.: Cancer Res., 54, 3772 (1994),

Fórmula: C₉H₁₁IN₂O₅

Forma y color: Neat

Peso molecular: 354.10

Ref: TR-I205750

2'-Deoxy-5-iodouridine

CAS: 54-42-2

2'-Deoxy-5-iodouridine is a novel nucleoside that has antiviral and anticancer properties. It is an analog of uridine, which is the building block for RNA. 2'-Deoxy-5-iodouridine can be phosphorylated to form diphosphate, monophosphate, and triphosphate forms. It can also be modified to form phosphoramidites or deoxyribonucleosides. This drug has been shown to have anticancer effects on various types of cancer cells and has been used in the treatment of leukemia and other cancers.

Fórmula: C₉H₁₁IN₂O₅

Pureza: Min. 99.0 Area-%

Peso molecular: 354.1 g/mol

Ref: 3D-Q-201230

2'-Deoxy-5-iodouridine

CAS: 54-42-2

2'-Deoxy-5-iodouridine (IDU) is a nucleoside that inhibits viral replication by inhibiting the synthesis of viral DNA. IDU has been shown to be a potent inhibitor of murine sarcoma virus and human immunodeficiency virus (HIV). IDU also has inhibitory properties on axonal growth, which may be due to its ability to inhibit DNA polymerase II. 2'-Deoxy-5-iodouridine is biocompatible, non-toxic, and can be used in high concentrations without any acute toxicities.

Fórmula: C₉H₁₁IN₂O₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 354.1 g/mol

Ref: 3D-ND05147

2'-Deoxy-5-iodouridine - EP

CAS: 54-42-2

2'-Deoxy-5-iodouridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein. 2'-Deoxy-5-iodouridine has been shown to inhibit the growth of human HL60 cells in vitro at an optimum concentration of 20 μM. It also inhibits the replication of murine sarcoma virus at an optimum concentration of 16 μM.
2'-Deoxy-5-iodouridine has significant cytotoxicity against solid tumours in mice, which may be due to its ability to inhibit hydrogen fluoride (HF) induced lipid peroxidation and reduce glutathione levels.

Fórmula: C₉H₁₁IN₂O₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 354.1 g/mol

Ref: 3D-ND172114

5-Iodo-2′-deoxyuridine

CAS: 54-42-2

Fórmula: C₉H₁₁IN₂O₅

Pureza: 95%

Forma y color: Solid, White powder

Peso molecular: 354.1

Ref: 10-F092965

5-Iodo-2-Deoxyuridine extrapure, 98%

CAS: 54-42-2

Fórmula: C₉H₁₁IN₂O₅

Pureza: min. 98%

Forma y color: White to off-white, Crystalline powder

Peso molecular: 354.10

Ref: SR-83441

Idoxuridine

CAS: 54-42-2

Forma y color: Neat

Ref: 61-FOR0791.00