CAS 54-42-2
:5-Iodo-2'-desoxiuridina
Descripción:
5-Iodo-2'-desoxiuridina (IDU) es un análogo de nucleósido de la timidina, caracterizado por la presencia de un átomo de yodo en la posición 5 del anillo de pirimidina. Se utiliza principalmente en la investigación antiviral y como un posible agente terapéutico en el tratamiento del cáncer debido a su capacidad para interferir con la síntesis de ADN. El IDU es un polvo cristalino blanco a blanco sucio que es soluble en agua y presenta un perfil de estabilidad moderado en condiciones fisiológicas. Su fórmula molecular es C₁₃H₁₂I N₃O₅, y tiene un peso molecular que refleja su estructura compleja. Se sabe que el compuesto inhibe la replicación viral, particularmente en el contexto del virus del herpes simple, y también se estudia por sus efectos en los procesos celulares. El IDU puede incorporarse al ADN durante la replicación, lo que lleva a mutaciones y, en última instancia, a la muerte celular, que es un mecanismo explotado en la terapia del cáncer. Se requieren precauciones de seguridad y manejo debido a sus posibles efectos biológicos, y debe utilizarse en entornos de laboratorio controlados.
Fórmula:C9H11IN2O5
InChI:InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
Clave InChI:InChIKey=XQFRJNBWHJMXHO-RRKCRQDMSA-N
SMILES:O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(I)C(=O)N1
Sinónimos:- 1-(2-Dehydroxy-β-D-ribofuranosyl)-5-iodouracil
- 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-iodouracil
- 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil
- 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
- 1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
- 1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]-5-iodopyrimidine-2,4(1H,3H)-dione
- 2'-Desoxy-5-iodouridine
- 2-Deoxy-5-iodouridine
- 5-Iodo-2'-Deoxy-D-Uridine
- 5-Iodo-2'-desoxyuridine
- 5-Iodo-deoxyuridine
- 5-Iododeoxyuridine
- 5-Iodouracil deoxyriboside
- 5Iudr
- Allergan 211
- Dendrid
- Emanil
- Herpe-Gel
- Herpesil
- Herpidu
- Herplex
- IDU
- Idexur
- Idoxene
- Idoxuridin
- Idoxuridina
- Idoxuridine
- Idu Oculos
- Iducher
- Idulea
- Idur
- Iduridin
- Iododeoxyuridine
- Iudr
- Joddeoxiuridin
- Kerecid
- Nsc 39661
- Ophthalmadine
- Skf 14287
- Stoxil
- Stoxip
- Synmiol
- Uridine, 2'-deoxy-5-iodo-
- Virudox
- Ver más sinónimos
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5-Iodo-2'-deoxyuridine
CAS:Fórmula:C9H11IN2O5Pureza:>99.0%(T)Forma y color:White to Almost white powder to crystalPeso molecular:354.10(+)-5-Iodo-2'-deoxyuridine, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo SciFórmula:C9H11IN2O5Pureza:98%Forma y color:Crystals or powder or crystalline powder, White to pale creamPeso molecular:354.10IDOXURIDINE CRS
CAS:IDOXURIDINE CRSFórmula:C9H11IN2O5Forma y color:Added ModifiedPeso molecular:354.0985Idoxuridine
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C9H11IN2O5Forma y color:White Crystalline PowderPeso molecular:353.97127Idoxuridine
CAS:Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.Fórmula:C9H11IN2O5Pureza:99.45% - 99.62%Forma y color:SolidPeso molecular:354.15-Iodo-2'-deoxyuridine
CAS:5-Iodo-2'-deoxyuridineFórmula:C9H11IN2O5Pureza:>99%Forma y color:SolidPeso molecular:354.0955-Iodo-2''-deoxyuridine
CAS:Fórmula:C9H11IN2O5Pureza:≥ 98.5%Forma y color:White to off-white crystalline powderPeso molecular:354.10Idoxuridine
CAS:Producto controladoApplications Idoxuridine is an antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents.
References Chang, C., et al.: J. Biol. Chem., 267, 22414 (1992), Pressacco, J., et al.: Cancer Res., 54, 3772 (1994),Fórmula:C9H11IN2O5Forma y color:NeatPeso molecular:354.12'-Deoxy-5-iodouridine
CAS:2'-Deoxy-5-iodouridine (IDU) is a nucleoside that inhibits viral replication by inhibiting the synthesis of viral DNA. IDU has been shown to be a potent inhibitor of murine sarcoma virus and human immunodeficiency virus (HIV). IDU also has inhibitory properties on axonal growth, which may be due to its ability to inhibit DNA polymerase II. 2'-Deoxy-5-iodouridine is biocompatible, non-toxic, and can be used in high concentrations without any acute toxicities.Fórmula:C9H11IN2O5Pureza:Min. 95%Forma y color:PowderPeso molecular:354.1 g/mol2'-Deoxy-5-iodouridine - EP
CAS:2'-Deoxy-5-iodouridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein. 2'-Deoxy-5-iodouridine has been shown to inhibit the growth of human HL60 cells in vitro at an optimum concentration of 20 μM. It also inhibits the replication of murine sarcoma virus at an optimum concentration of 16 μM. 2'-Deoxy-5-iodouridine has significant cytotoxicity against solid tumours in mice, which may be due to its ability to inhibit hydrogen fluoride (HF) induced lipid peroxidation and reduce glutathione levels.Fórmula:C9H11IN2O5Pureza:Min. 95%Forma y color:PowderPeso molecular:354.1 g/mol5-Iodo-2′-deoxyuridine
CAS:Fórmula:C9H11IN2O5Pureza:95%Forma y color:Solid, White powderPeso molecular:354.1Idoxuridine
CAS:1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dioneFórmula:C9H11IN2O5Pureza:98%Peso molecular:354.15-Iodo-2-Deoxyuridine extrapure, 98%
CAS:Fórmula:C9H11IN2O5Pureza:min. 98%Forma y color:White to off-white, Crystalline powderPeso molecular:354.10
