CAS 54-62-6
:Aminopterina
Descripción:
Aminopterina es un antagonista del folato y un miembro de la clase de compuestos Aminopterina, conocido principalmente por su papel como antimetabolito en la terapia del cáncer y como agente inmunosupresor. Es un polvo cristalino blanco a amarillo pálido que es soluble en agua y presenta un perfil de solubilidad dependiente del pH. La estructura química de Aminopterina presenta un anillo de pteridina, que es esencial para su actividad biológica, e inhibe la enzima dihidrofólico reductasa, interfiriendo así con la síntesis de ADN y la proliferación celular. Este mecanismo lo hace efectivo en el tratamiento de ciertos tipos de leucemia y otras malignidades. Además, Aminopterina se ha utilizado en entornos de investigación para estudiar el metabolismo del folato y sus implicaciones en varios procesos biológicos. Sin embargo, su uso está asociado con efectos secundarios significativos, incluyendo supresión de la médula ósea y trastornos gastrointestinales, lo que requiere un monitoreo cuidadoso durante el tratamiento. Debido a estas características, Aminopterina es un compuesto crítico tanto en aplicaciones clínicas como en investigaciones dentro del campo de la química medicinal.
Fórmula:C19H20N8O5
InChI:InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
Clave InChI:InChIKey=TVZGACDUOSZQKY-LBPRGKRZSA-N
SMILES:NC=1C2=C(N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
Sinónimos:- (2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
- 4-Amino-4-Deoxypteroylglutamate
- 4-Amino-Folicaci
- 4-Amino-Pga[Qr]
- 4-Aminofolic Acid
- 4-Aminofolicacid[Qr]
- 4-Aminopteroylglutamic acid
- 4-Aminopteroylglutamicacid[Qr]
- 4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)-N-(P-(((L-Glutamicaci
- <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
- Acide N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamique
- Agpa
- Ai3-26079[Qr]
- Aminopterin
- Aminopterine
- Apga
- Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
- Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L-
- L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
- N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
- N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)glutamic acid
- N-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)carbonyl]-D-glutamic acid
- N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
- N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsaure
- N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
- Nsc 739
- Pteramina
- Pteridin-2-Amine
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Se han encontrado 12 productos.
Aminopterin
CAS:Fórmula:C19H20N8O5Pureza:>97.0%(T)(HPLC)Forma y color:White to Amber powder to crystalPeso molecular:440.42Methotrexate Related Compound B ((S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid)
CAS:Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoiFórmula:C19H20N8O5Forma y color:White Yellow PowderPeso molecular:440.41Aminopterin dihydrate
CAS:Fórmula:C19H20N8O5·xH2OPureza:≥ 97.0%Forma y color:Pale yellow to yellow-brown powderPeso molecular:440.41 (anhydrous)(2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic Acid (4-Aminofolic Acid, Aminopterin)
CAS:Producto controladoFórmula:C19H20N8O5Forma y color:NeatPeso molecular:440.41Aminopterin
CAS:Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductaseFórmula:C19H20N8O5Pureza:≥98%Forma y color:Yellow SolidPeso molecular:440.41Methotrexate EP Impurity B (Methotrexate USP Related Compound B)
CAS:Fórmula:C19H20N8O5Peso molecular:440.42Aminopterin
CAS:Impurity Methotrexate EP Impurity B
Applications Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998),Fórmula:C19H20N8O5Forma y color:NeatPeso molecular:440.41Aminopterin
CAS:Aminopterin is an antineoplastic agent and antifolate, which is a synthetic derivative of pteroylglutamic acid. It functions as a chemotherapeutic agent by inhibiting dihydrofolate reductase, an enzyme crucial in the folic acid pathway, thereby preventing the conversion of dihydrofolate to tetrahydrofolate. This disruption leads to impaired synthesis of purine nucleotides and thymidylate, which are essential for DNA synthesis and cell division.Fórmula:C19H20N8O5Pureza:Min. 97 Area-%Forma y color:Slightly Yellow PowderPeso molecular:440.41 g/molAminopterin
CAS:(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)amino)benzamido)pentanedioic acidFórmula:C19H20N8O5Pureza:97%Peso molecular:440.41
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