CAS 5490-27-7

Sulfato de dihidroestreptomicina

Descripción:

Sulfato de dihidroestreptomicina es un antibiótico aminoglucósido derivado de Streptomyces griseus, utilizado principalmente para tratar infecciones bacterianas, particularmente aquellas causadas por Mycobacterium tuberculosis. Se caracteriza por su capacidad para inhibir la síntesis de proteínas bacterianas al unirse a la subunidad ribosomal 30S, lo que lleva a una lectura errónea del ARNm y, en última instancia, a la muerte celular bacteriana. El compuesto se administra típicamente por inyección debido a su baja biodisponibilidad oral. Sulfato de dihidroestreptomicina es soluble en agua, lo que facilita su uso en entornos clínicos. Su estructura química incluye múltiples grupos amino, lo que contribuye a su basicidad e interacción con los ribosomas bacterianos. Si bien es efectivo contra una variedad de bacterias Gram-negativas y algunas Gram-positivas, es importante monitorear los posibles efectos secundarios, incluida la nefrotoxicidad y la ototoxicidad, que son preocupaciones comunes con los aminoglucósidos. Al igual que con todos los antibióticos, se recomienda realizar pruebas de susceptibilidad adecuadas para garantizar la eficacia contra patógenos específicos.

Fórmula: C₂₁H₄₁N₇O₁₂H₂O₄S

InChI: InChI=1S/C21H41N7O12.H2O4S/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;1-5(2,3)4/h5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28);(H2,1,2,3,4)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;/m0./s1

Clave InChI: InChIKey=GSPKOIJAMLDYCY-RMIBZTJPSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@@H]2[C@@H](NC(=N)N)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]2O)O[C@@H](C)[C@@]1(CO)O)[C@H]3[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3

Sinónimos:

• 2,2'-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (1:1)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-deoxy-2-(methylamino)-α-<smallcap>L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-<smallcap>L</span>-lyxofuranosyl-(1→4)-N,N′-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-deoxy-2-(methylamino)-α-<smallcap>L</smallcap>-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-<smallcap>L</span>-lyxofuranosyl-(1→4)-N¹,N³-bis(aminoiminomethyl)-, sulfate (2:3)
• Didromycin
• Didromycine
• Dihydroestreptomycin Sulphate
• Dihydrostereptomycin Sulfate
• Dihydrostreptomycin 3/2 sulfate
• Dihydrostreptomycin Suflate
• Dihydrostreptomycin Sulfate(2:3)
• Dihydrostreptomycin sesqui-Sulfate
• Dihydrostreptomycin sesquisulfate
• Dihydrostreptomycin sulfate
• Double-mycin
• N'',N'''''-[(1S,2S,3R,4S,5S,6R)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine sulfate (2:3) (salt)
• Panstreptin
• Sol-Mycin
• Streptomagna
• Streptomycin, dihydro-, sulfate (2:3) (salt)
• D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3)

DIHYDROSTREPTOMYCIN SULFATE CRS

CAS: 5490-27-7

DIHYDROSTREPTOMYCIN SULFATE CRS

Fórmula: C₂₁H₄₃N₇O₁₆S

Peso molecular: 681.6684

Ref: 41-D1954000

Dihydrostreptomycin Sulfate

CAS: 5490-27-7

Dihydrostreptomycin and its derivatives; salts thereof

Fórmula: (C₂₁H₄₁N₇O₁₂)₂·3H₂SO₄

Forma y color: White Powder

Peso molecular: 1166.56264

Ref: 45-1203008

Dihydrostreptomycin Sulfate

CAS: 5490-27-7

Fórmula: C₂₁H₄₁N₇O₁₂·3H₂O₄S

Forma y color: White To Off-White Solid

Peso molecular: 2 583.60 3 98.08

Ref: 4Z-S-083005

Dihydrostreptomycin sesquisulfate

CAS: 5490-27-7

Fórmula: C₂₁H₄₁N₇O₁₂₁·5H₂SO₄

Pureza: ≥ 730IU/mg (anhydrous)

Forma y color: White to off-white powder

Peso molecular: 730.71

Ref: 7W-GA8949

Dihydrostreptomycin sesquisulfate

Producto controlado

CAS: 5490-27-7

Fórmula: C₂₁H₄₁N₇O₁₂H₂O₄S

Forma y color: Neat

Peso molecular: 1461.42

Ref: 04-C12635300

Dihydrostreptomycin sesquisulfate 100 µg/mL in Acetonitrile/Water

CAS: 5490-27-7

Fórmula: C₂₁H₄₁N₇O₁₂H₂O₄S

Forma y color: Single Solution

Peso molecular: 1461.42

Ref: 04-A12635300WL-100

Dihydrostreptomycin sulfate

CAS: 5490-27-7

Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit.

Fórmula: C₂₁H₄₁N₇O₁₂·5H₂SO₄

Pureza: 97.38% - 99.9%

Forma y color: Solid

Peso molecular: 730.71

Ref: TM-T2211

Dihydrostreptomycin Sesquisulfate

CAS: 5490-27-7

Stability Hygroscopic
Applications A derivative of Streptomycin (S687500) with antimicrobial activity. It is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.
References Gradin, J.L. et al.: J. Am. Vet. Med. Assoc., 183, 434 (1983); Bishop, J.R. et al.: J. Dairy Sci., 67, 437 (1984); Singh, D.R. et al.: Obi. Chik. Daig. Gak. Ken. Hok., 11, 475 (1979);

Fórmula: C₂₁H₄₁N₇O₁₂·3H₂O₄S

Forma y color: Off-White

Peso molecular: 1461.42

Ref: TR-D449535

Dihydrostreptomycin sesquisulfate, EP

CAS: 5490-27-7

Dihydrostreptomycin sesquisulfate, EP is an aminoglycoside antibiotic, structurally derived from Streptomyces griseus. This compound originates from microbial biosynthesis, a method which harnesses the natural antibiotic-producing capabilities of microbial cultures. The mode of action of dihydrostreptomycin sesquisulfate involves binding to the 30S subunit of bacterial ribosomes, which interrupts the process of protein synthesis, ultimately leading to bacterial cell death.

Fórmula: C₂₁H₄₁N₇O₁₂•(H₂SO₄)₁

Pureza: (Hplc) 94.0 To 102.0%

Forma y color: Powder

Peso molecular: 1,461.42 g/mol

Ref: 3D-AD175759

Dihydrostreptomycin sesquisulfate

CAS: 5490-27-7

Dihydrostreptomycin sesquisulfate is an aminoglycoside antibiotic, which is derived from the bacterium Streptomyces griseus. Its mode of action involves binding to the 30S subunit of the bacterial ribosome, leading to the disruption of protein synthesis. This binding interferes with the initiation complex formation, causing misreading of mRNA and ultimately inhibiting bacterial growth.

Fórmula: C₂₁H₄₁N₇O₁₂•(H₂SO₄)₁

Pureza: Min. 95%

Peso molecular: 730.71 g/mol

Ref: 3D-AD22045