CAS 59865-13-3
:Ciclosporina A
Descripción:
Ciclosporina A es un polipéptido cíclico compuesto por 11 aminoácidos, conocido principalmente por sus propiedades inmunosupresoras. Es producido por el hongo Tolypocladium inflatum y se utiliza ampliamente en entornos clínicos, particularmente en trasplantes de órganos y enfermedades autoinmunes, para prevenir el rechazo de órganos y manejar condiciones como la artritis reumatoide. La sustancia funciona inhibiendo la activación de los linfocitos T, reduciendo así la respuesta inmune. Ciclosporina A es lipofílico, lo que afecta su absorción y distribución en el cuerpo; generalmente se administra por vía oral o intravenosa. Su farmacocinética puede verse influenciada por varios factores, incluyendo la ingesta de alimentos y medicamentos concurrentes, lo que requiere un monitoreo cuidadoso de los niveles en sangre para evitar toxicidad. Los efectos adversos pueden incluir nefrotoxicidad, hipertensión y mayor susceptibilidad a infecciones. Debido a sus interacciones complejas y efectos secundarios, Ciclosporina A requiere una gestión cuidadosa y ajustes de dosis basados en la respuesta individual del paciente y el contexto clínico.
Fórmula:C62H111N11O12
InChI:InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
Sinónimos:- Cyclosporina
- Cyclosporine
- Cyclosporin
- Restasis
- cyclosporin A
- Antibiotic S 7481F1
- 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
- (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
- 1: PN: US6686454 SEQID: 1 claimed protein
- 7: PN: WO0002548 PAGE: 30 claimed protein
- Arpimune ME
- Cicloral
- Cicloral (antibiotic)
- Ciclosporin
- Cipol N
- Consupren
- Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- Debio088
- Equoral
- Gengraf
- Neoplanta
- Neoral
- Nsc 290193
- Ol 27-400
- Papilock Mini
- Ramihyphin A
- Sandimmun
- Sandimmune
- Sandimmune Neoral
- Sang-35
- SangCyA
- Sdz-Oxl 400
- Sigmasporin Microoral
- S-Neoral
- Zinograf ME
- Ver más sinónimos
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Encontrado 26 productos.
Cyclosporin A
CAS:Fórmula:C62H111N11O12Pureza:>97.0%(HPLC)(N)Forma y color:White to Almost white powder to crystalPeso molecular:1,202.64Cyclosporin A, 99+%
CAS:<p>Cyclosporin A, 59865-13-3, or cyclosporine, is a cyclic polypeptide which acts as a calcineurin inhibitor and immunosuppressive agent. Learn more at Thermo Fisher Scientific.</p>Fórmula:C62H111N11O12Pureza:99+%Forma y color:White, Powder or crystals or crystalline powderPeso molecular:1202.61CICLOSPORIN FOR SYSTEM SUITABILITY A CRS
CAS:CICLOSPORIN FOR SYSTEM SUITABILITY A CRSForma y color:AddedCyclosporine
CAS:Lactams, nesoiFórmula:C62H111N11O12Forma y color:White PowderPeso molecular:1201.84137Ref: IN-DA00IKI7
1g40,00€5g91,00€1kgA consultar25g237,00€100gA consultar250gA consultar500gA consultar100mg24,00€250mg26,00€Cyclosporin A
CAS:Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.Fórmula:C62H111N11O12Pureza:99.00% - 99.92%Forma y color:White PowderPeso molecular:1202.61Cyclosporin A (Cyclosporine)
CAS:Fórmula:C62H111N11O12Forma y color:White To Off-White SolidPeso molecular:1202.64Cyclosporine A from Beauveria Nivea
CAS:<p>Cyclosporine A from Beauveria Nivea</p>Pureza:99%Forma y color:White SolidPeso molecular:1,202.61g/molCyclosporin A
CAS:Fórmula:C62H111N11O12Pureza:98.5 - 101.5 % (dried basis)Forma y color:Colourless crystals, or white to almost white powderPeso molecular:1202.61Cyclosporin A from Tolypocladium inflatum
CAS:Cyclosporin A from Tolypocladium inflatumFórmula:C62H111N11O12Pureza:By hplc: >99% (Typical Value in Batch COA)Forma y color: white solidPeso molecular:1,202.61g/molCyclosporin A, USP grade
CAS:Fórmula:C62H111N11O12Pureza:≤ 0.7%Forma y color:Colourless crystals, or white to almost white powderPeso molecular:1202.61Cyclosporin A
CAS:<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C62H111N11O12Forma y color:NeatPeso molecular:1202.61Cyclosporin A-d4 (Major)
CAS:Producto controlado<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C62H107D4N11O12Forma y color:NeatPeso molecular:1206.66Cyclosporin A-13C2,d4 (Major)
CAS:Producto controlado<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C2C60D4H107N11O12Forma y color:NeatPeso molecular:1208.62Cyclosporin A
CAS:<p>Binds cyclophilin D and inhibits calcineurin; immunosuppressant</p>Fórmula:C62H111N11O12Pureza:Min. 98.5 Area-%Forma y color:White PowderPeso molecular:1,202.61 g/molCyclosporin A - Bio-X ™
CAS:<p>Cyclosporin A (CsA) is a cyclic undecapeptide that is extracted from the fungus Tolypocladium inflatum. CsA is used as an immunosuppressive drug to prevent rejection of transplanted organs and to treat autoimmune diseases such as rheumatoid arthritis and psoriasis. CsA works by binding to a protein called cyclophilin D, which is a component of the enzyme calcineurin. Calcineurin is an important enzyme involved in the activation of immune cells, and by binding to cyclophilin D, CsA inhibits its activity. This leads to the inhibition of T-cell activation and the suppression of the immune response. Cyclosporin A has has been rpeorted to exhibit some nephrotoxicity, hypertension and also increases the risk of infections and tumors when used in transplantation</p>Fórmula:C62H111N11O12Pureza:Min. 95%Forma y color:White PowderPeso molecular:1,202.61 g/molEverolimus, Cyclosporine and Tacrolimus Mix Standard
CAS:Producto controladoFórmula:MixtureVisitourWebsiteForma y color:MixturePeso molecular:Mixture - Visit our Website
