CAS 59865-13-3

Ciclosporina A

Descripción:

Ciclosporina A es un polipéptido cíclico compuesto por 11 aminoácidos, conocido principalmente por sus propiedades inmunosupresoras. Es producido por el hongo Tolypocladium inflatum y se utiliza ampliamente en entornos clínicos, particularmente en trasplantes de órganos y enfermedades autoinmunes, para prevenir el rechazo de órganos y manejar condiciones como la artritis reumatoide. La sustancia funciona inhibiendo la activación de los linfocitos T, reduciendo así la respuesta inmune. Ciclosporina A es lipofílico, lo que afecta su absorción y distribución en el cuerpo; generalmente se administra por vía oral o intravenosa. Su farmacocinética puede verse influenciada por varios factores, incluyendo la ingesta de alimentos y medicamentos concurrentes, lo que requiere un monitoreo cuidadoso de los niveles en sangre para evitar toxicidad. Los efectos adversos pueden incluir nefrotoxicidad, hipertensión y mayor susceptibilidad a infecciones. Debido a sus interacciones complejas y efectos secundarios, Ciclosporina A requiere una gestión cuidadosa y ajustes de dosis basados en la respuesta individual del paciente y el contexto clínico.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

Sinónimos:

• Cyclosporina
• Cyclosporine
• Cyclosporin
• Restasis
• cyclosporin A
• Antibiotic S 7481F1
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 1: PN: US6686454 SEQID: 1 claimed protein
• 7: PN: WO0002548 PAGE: 30 claimed protein
• Arpimune ME
• Cicloral
• Cicloral (antibiotic)
• Ciclosporin
• Cipol N
• Consupren
• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• Debio088
• Equoral
• Gengraf
• Neoplanta
• Neoral
• Nsc 290193
• Ol 27-400
• Papilock Mini
• Ramihyphin A
• Sandimmun
• Sandimmune
• Sandimmune Neoral
• Sang-35
• SangCyA
• Sdz-Oxl 400
• Sigmasporin Microoral
• S-Neoral
• Zinograf ME

Cyclosporin A

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Forma y color: Neat

Peso molecular: 1202.61

Ref: TR-C988900

Cyclosporin A-d4 (Major)

Producto controlado

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₆₂H₁₀₇D₄N₁₁O₁₂

Forma y color: Neat

Peso molecular: 1206.66

Ref: TR-C988902

Cyclosporin A-13C2,d4 (Major)

Producto controlado

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂

Forma y color: Neat

Peso molecular: 1208.62

Ref: TR-C988901

Cyclosporin A

CAS: 59865-13-3

Binds cyclophilin D and inhibits calcineurin; immunosuppressant

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: Min. 98.5 Area-%

Forma y color: White Powder

Peso molecular: 1,202.61 g/mol

Ref: 3D-FC20749

Cyclosporin A - Bio-X ™

CAS: 59865-13-3

Cyclosporin A (CsA) is a cyclic undecapeptide that is extracted from the fungus Tolypocladium inflatum. CsA is used as an immunosuppressive drug to prevent rejection of transplanted organs and to treat autoimmune diseases such as rheumatoid arthritis and psoriasis. CsA works by binding to a protein called cyclophilin D, which is a component of the enzyme calcineurin. Calcineurin is an important enzyme involved in the activation of immune cells, and by binding to cyclophilin D, CsA inhibits its activity. This leads to the inhibition of T-cell activation and the suppression of the immune response. Cyclosporin A has has been rpeorted to exhibit some nephrotoxicity, hypertension and also increases the risk of infections and tumors when used in transplantation

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 1,202.61 g/mol

Ref: 3D-BC164336

Everolimus, Cyclosporine and Tacrolimus Mix Standard

Producto controlado

CAS: 104987-11-3, 159351-69-6, 59865-13-3

Fórmula: MixtureVisitourWebsite

Forma y color: Mixture

Peso molecular: Mixture - Visit our Website

Ref: TR-E608165