CAS 6199-67-3

(+)-Cucurbitacina B

Fórmula: C₃₂H₄₆O₈

InChI: InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1

Clave InChI: InChIKey=IXQKXEUSCPEQRD-DKRGWESNSA-N

SMILES: C[C@]12[C@@](C)([C@@]([C@@](C(/C=C/C(OC(C)=O)(C)C)=O)(C)O)([C@H](O)C1)[H])CC(=O)[C@]3(C)[C@]2(CC=C4[C@]3(C[C@H](O)C(=O)C4(C)C)[H])[H]

Sinónimos:

• (23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha,17xi,23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2S,4R,9beta,16alpha,23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
• (2β,9β,10α,16α,23E)-25-(Acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
• 19-Nor-9β,10α-lanosta-5,23-diene-3,11,22-trione, 2β,16α,20,25-tetrahydroxy-9-methyl-, 25-acetate
• 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-
• Amarine
• Cucurbitacine B
• Hy-N 0416
• NSC 144154
• NSC 49451

Cucurbitacin B

CAS: 6199-67-3

Fórmula: C₃₂H₄₆O₈

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 558.71

Ref: 3B-C3442

CUCURBITACIN B

CAS: 6199-67-3

CUCURBITACIN B

Pureza: 98%

Peso molecular: 558.7119751

Ref: 10-F809664

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B

Fórmula: C₃₂H₄₆O₈

Pureza: 99.5%

Peso molecular: 558.712

Ref: 54-BUP02619

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B (cucB) is a triterpenoid constituent of Cucurbitaceae vegetables and a promising phytochemical for cancer prevention, cucB induces G(2) arrest and apoptosis through a STAT3-independent but ROS-dependent mechanism in SW480 cells.

Fórmula: C₃₂H₄₆O₈

Pureza: 95%~99%

Forma y color: White powder

Peso molecular: 558.712

Ref: BP-BP0414

Cucurbitacin B (Standard)

CAS: 6199-67-3

Cucurbitacin B (Standard) is the standard of Cucurbitacin B, suitable for quantitative analysis, quality control, and biochemical experiments and related research.

Fórmula: C₃₂H₄₆O₈

Forma y color: Solid

Peso molecular: 558.70

Ref: TM-TMSM-1841

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₃₂H₄₆O₈

Pureza: (HPLC) ≥95%

Forma y color: Powder

Peso molecular: 558.72

Ref: 11-2310S

(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

CAS: 6199-67-3

(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

Fórmula: C₃₂H₄₆O₈

Pureza: 99%

Peso molecular: 558.7

Ref: IN-DG122458

Cucurbitacin B

CAS: 6199-67-3

Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.

Fórmula: C₃₂H₄₆O₈

Pureza: 97.1% - 99.93%

Forma y color: White Solid

Peso molecular: 558.70

Ref: TM-T3404

Cucurbitacin B

CAS: 6199-67-3

Fórmula: C₃₂H₄₆O₈

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 558.71

Ref: 7W-GY2441

Cucurbitacin B

CAS: 6199-67-3

Fórmula: C₃₂H₄₆O₈

Peso molecular: 558.71

Ref: 4Z-C-266004

Cucurbitacin B

CAS: 6199-67-3

Carboxylic acid with additional oxygen functions

Fórmula: C₃₂H₄₆O₈

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 558.71

Ref: 5G-82226

Cucurbitacin B

Producto controlado

CAS: 6199-67-3

Cucurbitacin B is a triterpenoid compound, which is derived from plants primarily within the Cucurbitaceae family. This compound exhibits its mode of action through the inhibition of the JAK-STAT signaling pathway, effectively disrupting processes that are critical for cell survival and proliferation. As a result, Cucurbitacin B is being extensively studied for its antiproliferative and pro-apoptotic properties, especially in the context of cancer research.

Fórmula: C₃₂H₄₆O₈

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 558.7 g/mol

Ref: 3D-FC66008

Cucurbitacin B

CAS: 6199-67-3

Fórmula: C₃₂H₄₆O₈

Forma y color: Solid; [Merck Index]

Peso molecular: 558.7

Ref: BE-RMCC392004

Cucurbitacin B

CAS: 6199-67-3

Fórmula: C₃₂H₄₆O₈

Forma y color: Solid; [Merck Index]

Peso molecular: 558.7

Ref: BE-RMT12220

Cucurbitacin B

Producto controlado

CAS: 6199-67-3

Applications Cucurbitacin B is a tetracyclic triterpenoid, which can induce apoptosis in human hepatoma cells. It can also induce DNA damage and autophagy in MCF-7 breast cancer cells.In the wild, watermelons, cucumbers, and muskmelons produce bitter Cucurbitacins to defend against preditors. Humans have bred these fruits to eliminate these compounds thereby yielding fruits that are more appealing to our palate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sun, Y., et al.: Eur. J. Pharmacol. 768, 28 (2015); Ren, G., et al.: J. Nat. Med. 69, 522 (2015); C&E News p. 10, Dec. 5, 2016j

Fórmula: C₃₂H₄₆O₈

Forma y color: Neat

Peso molecular: 558.7

Ref: TR-C833550