CAS 637-32-1

Clorhidrato de proguanil

Descripción:

Clorhidrato de proguanil es un medicamento antipalúdico que se utiliza principalmente en la prevención y tratamiento de la malaria. Es un compuesto sintético que pertenece a la clase de fármacos biguanidas. La sustancia se caracteriza por su forma de polvo cristalino blanco a blanco sucio, que es soluble en agua y presenta un sabor ligeramente amargo. Clorhidrato de proguanil actúa como un profármaco, siendo metabolizado en el hígado a su forma activa, cicloguanil, que inhibe la dihidrofolato reductasa, una enzima crucial para la síntesis de folato en el parásito de la malaria. Esta acción interrumpe la capacidad del parásito para reproducirse y sobrevivir dentro del huésped. El compuesto tiene un perfil de toxicidad relativamente bajo, lo que lo hace adecuado para su uso en diversas poblaciones, incluidos niños y mujeres embarazadas. Además, a menudo se utiliza en combinación con otros agentes antipalúdicos para mejorar la eficacia y reducir el riesgo de desarrollo de resistencia. Al igual que con cualquier medicamento, es esencial considerar los posibles efectos secundarios y contraindicaciones al prescribir o usar Clorhidrato de proguanil.

Fórmula: C₁₁H₁₇Cl₂N₅

InChI: InChI=1/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H

Clave InChI: InChIKey=SARMGXPVOFNNNG-UHFFFAOYSA-N

SMILES: N(C(NC(NC(C)C)=N)=N)C1=CC=C(Cl)C=C1.Cl

Sinónimos:

• 1-(p-Chlorophenyl)-5-isopropylbiguanide hydrochloride
• 1-[N′-(4-Chlorophenyl)carbamimidamido]-N-(propan-2-yl)methanimidamide hydrochloride
• 1-{(1E)-amino[(4-chlorophenyl)amino]methylidene}-2-(1-methylethyl)guanidine hydrochloride
• 3359 Rp
• Biguanide, 1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride
• Chloroguanide hydrochloride
• Chloroquanil
• Diguanyl
• Drinupal
• Drinupal hydrochloride
• Guanatol
• Guanatol hydrochloride
• Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Hydrochloride (1:1)
• Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N′-(1-methylethyl)-, monohydrochloride
• M 4888
• Paludrine
• Paludrine hydrochloride
• Palusil
• Palusil hydrochloride
• Proguanil HCL
• Rp 3359
• Sn 12,837
• Tirian
• Tirian hydrochloride
• chlorguanidehydrochloride
• Proguanil Hydrochloride (200 mg)
• drinupalhydrochloride
• Paludrin
• m4888
• PROGUANIL HYDROCHLORIDE
• n-4-chlorophenyl-n(sup5)-isopropyldiguanidehydrochloride
• Chlorguanid
• N1-(4-Chlorophenyl)-N5-isopropylbiguanide
• 1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride
• 3359rp
• sn12,837
• guanatolhydrochloride
• Chlorguanide Hydrochloride3
• palusilhydrochloride
• chloroguanidinehydrochloride
• N-(4-Chlorophenyl)-N'-(1-methylethyl)-imidodicarbonimidic Diamide Hydrochloride
• PROGUANIL HYDROCHLORIDE###N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
• paludrinehydrochloride
• ChlorguanideHCl
• chloroguanidehydrochloride

Proguanil Hydrochloride

CAS: 637-32-1

Forma y color: Neat

Ref: 61-FOR0840.00

PROGUANIL HYDROCHLORIDE CRS

CAS: 637-32-1

PROGUANIL HYDROCHLORIDE CRS

Fórmula: C₁₁H₁₇Cl₂N₅

Peso molecular: 290.1922

Ref: 41-Y0001901

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride

Fórmula: C₁₁H₁₆ClN₅HCl

Pureza: 99.6%

Forma y color: White Crystalline Powder

Peso molecular: 289.0861

Ref: 47-297

PROGUANIL FOR SYSTEM SUITABILITY CRS

CAS: 637-32-1

PROGUANIL FOR SYSTEM SUITABILITY CRS

Fórmula: C₁₁H₁₇Cl₂N₅

Forma y color: White. Crystalline Powder.

Peso molecular: 290.1922

Ref: 41-Y0001885

Proguanil Hydrochloride

CAS: 637-32-1

Aromatic imines and their derivatives, salts thereof

Fórmula: C₁₁H₁₆ClN₅·HCl

Forma y color: White Off-White Crystalline Powder

Peso molecular: 253.10942

Ref: 45-1568040

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride

Pureza: ≥98%

Peso molecular: 290.19g/mol

Ref: 54-BUP14518

Proguanil Hydrochloride

CAS: 637-32-1

Proguanil Hydrochloride

Pureza: 97%

Peso molecular: 290.19g/mol

Ref: 54-OR1023733

Proguanil Hydrochloride

Producto controlado

CAS: 637-32-1

Fórmula: C₁₁H₁₆ClN₅·ClH

Forma y color: Neat

Peso molecular: 290.19

Ref: 86-MM0840.00

Proguanil hydrochloride

CAS: 637-32-1

Fórmula: C₁₁H₁₆ClN₅·HCl

Peso molecular: 290.19

Ref: 7W-GL3057

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride, a biguanide, metabolizes into cycloguanil, an anti-malaria agent that inhibits plasmodium's DNA and protein synthesis.

Fórmula: C₁₁H₁₇Cl₂N₅

Pureza: 98.34% - 98.39%

Forma y color: Solid

Peso molecular: 290.19

Ref: TM-T4382

Chlorguanide Hydrochloride

Producto controlado

CAS: 637-32-1

Fórmula: C₁₁H₁₆ClN₅·ClH

Forma y color: White

Peso molecular: 290.19

Ref: TR-C329500

Proguanil hydrochloride

CAS: 637-32-1

Proguanil hydrochloride is a drug used to treat malaria. It is a prodrug that is activated in the liver by hepatic esterases and converted to chloroguanide. Proguanil hydrochloride binds to DNA-dependent RNA polymerase, which inhibits transcription and replication of bacterial DNA. This drug also has effects on cardiac cells and can worsen congestive heart disease. Proguanil hydrochloride has been shown to interact with other drugs, such as acetaminophen, phenytoin, and warfarin, which can result in serious side effects. Proguanil hydrochloride is not active against some types of bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.

Fórmula: C₁₁H₁₇Cl₂N₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 290.19 g/mol

Ref: 3D-FC19929

Chlorguanide-d6 Hydrochloride

Producto controlado

CAS: 637-32-1

Applications Chlorguanide-d6 Hydrochloride, is a labeled analogue of Chlorguanide (C329500), used as Antimalarial.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schmidt., et al.: J. Pharmacol. Exp. Ther., 90, 233 (1947), Cortese, J., et al.: J. Infect. Dis., 186, 999 (2002), Lim, P., et al.: Antimicrob. Agents Chemother., 47, 87 (2003), Sidhu, A., et al.: Mol. Microbiol., 57, 913 (2005),

Fórmula: C₁₁H₁₁D₆Cl₂N₅

Forma y color: Neat

Peso molecular: 296.23

Ref: TR-C329503