Proguanil hydrochloride

CAS: 637-32-1

Ref. TM-T4382

Información del producto

• Nombre: Proguanil hydrochloride
• Sinónimos: Paludrine hydrochloride, Chlorguanide hydrochloride, Chloroquanil, 1-(p-Chlorophenyl)-5-isopropylbiguanide hydrochloride, 1-[N′-(4-Chlorophenyl)carbamimidamido]-N-(propan-2-yl)methanimidamide hydrochloride, 1-{(1E)-amino[(4-chlorophenyl)amino]methylidene}-2-(1-methylethyl)guanidine hydrochloride, 3359 Rp, Biguanide, 1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride, Chloroguanide hydrochloride, Chloroquanil, Diguanyl, Drinupal, Drinupal hydrochloride, Guanatol, Guanatol hydrochloride, Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Hydrochloride (1:1), Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N′-(1-methylethyl)-, monohydrochloride, M 4888, Paludrine, Paludrine hydrochloride, Palusil, Palusil hydrochloride, Proguanil HCL, Rp 3359, Sn 12,837, Tirian, Tirian hydrochloride
• CAS: 637-32-1

Descripción

Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 290.19
• Fórmula: C₁₁H₁₇Cl₂N₅
• Pureza: 98.34%
• Color/Forma: Solid