CAS 689284-12-6

Fórmula: C19H37N5O5

InChI: InChI=1S/C19H37N5O5/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25)/t12-,13+,15+/m0/s1

Clave InChI: LMIQCBIEAHJAMZ-GZBFAFLISA-N

SMILES: C[C@@H](C(=O)NCCN)NC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(C)C)CC(=O)NO

TAPI 2

CAS: 689284-12-6

ADAM-17 inhibitor with Ki of 120 nM, enhances 5-FU lethality in cancer stem cells, prevents TNF-α release.

Fórmula: C₁₉H₃₇N₅O₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 415.54

Ref: TM-TP2108

TAPI-2 acetate salt

CAS: 689284-12-6

TAPI-2 is an inhibitor of ADAM-17 (also called TACE) and matrix metalloproteinases (MMPs). It acts as a broad-spectrum inhibitor of these enzymes. TAPI-2 prevents the shedding of tumor necrosis factor-alpha (TNF-α) from cell membranes and can sensitize cancer stem cells to the effects of chemotherapy such as 5-fluorouracil (5-FU) in vitro. It also blocks the phorbol ester-induced shedding of other cell surface proteins like TGF-α and β-amyloid precursor protein.

Fórmula: C₁₉H₃₇N₅O₅

Pureza: Min. 95%

Peso molecular: 415.53 g/mol

Ref: 3D-INH-3852-PI