CAS 7689-03-4

Camptotecina

Descripción:

Camptotecina es un alcaloide que se encuentra de forma natural y se deriva de la corteza del árbol chino Camptotheca acuminata. Se clasifica como un inhibidor de la topoisomerasa I, lo que significa que interfiere con la enzima responsable de la replicación y transcripción del ADN, lo que lleva, en última instancia, a la muerte celular, particularmente en células cancerosas que se dividen rápidamente. Camptotecina exhibe una estructura compleja caracterizada por un sistema de anillo pentacíclico, que es crucial para su actividad biológica. El compuesto es conocido por sus potentes propiedades antitumorales y ha sido la base para el desarrollo de varios derivados semisintéticos, como el irinotecán y el topotecán, que se utilizan en la terapia del cáncer. Camptotecina es relativamente insoluble en agua pero soluble en disolventes orgánicos, lo que puede presentar desafíos para su formulación y entrega en entornos clínicos. Su farmacocinética y perfil de toxicidad son consideraciones importantes en su aplicación terapéutica, ya que puede causar efectos secundarios como mielosupresión y trastornos gastrointestinales. En general, Camptotecina sigue siendo un compuesto significativo en la investigación y tratamiento del cáncer.

Fórmula: C₂₀H₁₆N₂O₄

InChI: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

Clave InChI: InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N

SMILES: C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=CC5)COC1=O

Sinónimos:

• (+)-Camptothecin
• (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (S)-Camptothecin
• 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-
• 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
• 20(S)-Camptothecin
• 20(S)-Camptothecine
• 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• Campathecin
• Campothecin
• Camptothccin
• Camptothecin, Camptotheca acuminata
• Mag-Cpt
• N-cyclohexyl-9-pentofuranosyl-9H-purin-6-amine
• Nsc 94600
• S-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• S-Ckd 602
• d-Camptothecin

(S)-(+)-Camptothecin

CAS: 7689-03-4

Fórmula: C₂₀H₁₆N₂O₄

Pureza: >97.0%(HPLC)

Forma y color: White to Yellow to Green powder to crystal

Peso molecular: 348.36

Ref: 3B-C1495

Topotecan Related Compound C ((S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS: 7689-03-4

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Fórmula: C₂₀H₁₆N₂O₄

Forma y color: Powder

Peso molecular: 348.11101

Ref: 45-1672280

(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

CAS: 7689-03-4

Fórmula: C₂₀H₁₆N₂O₄

Pureza: 95%

Forma y color: Solid

Peso molecular: 348.3520

Ref: IN-DA003BCG

(S)-(+)-Camptothecin

CAS: 7689-03-4

Fórmula: C₂₀H₁₆N₂O₄

Pureza: ≥ 95.0%

Forma y color: Light-yellow to brown crystalline powder

Peso molecular: 348.35

Ref: 7W-GA9966

Camptothecin

CAS: 7689-03-4

Camptothecin

Pureza: ≥98%

Peso molecular: 348.35g/mol

Ref: 54-BUP16805

Camptothecin

CAS: 7689-03-4

Fórmula: C₂₀H₁₆N₂O₄

Pureza: 95%~99%

Peso molecular: 348.358

Ref: BP-BP0308

(S)-(+)-Camptothecin

CAS: 7689-03-4

Forma y color: Neat

Ref: 86-MM1330.02

(S)-(+)-Camptothecin

CAS: 7689-03-4

(S)-(+)-Camptothecin

Fórmula: C₂₀H₁₆N₂O₄

Pureza: 98% (Typical Value in Batch COA)

Forma y color: faint yellow powder

Peso molecular: 348.35203g/mol

Ref: 54-BIC8442

Irinotecan EP Impurity D (Camptothecin)

CAS: 7689-03-4

Fórmula: C₂₀H₁₆N₂O₄

Peso molecular: 348.36

Ref: 4Z-I-1811

(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

CAS: 7689-03-4

(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Pureza: ≥95%

Forma y color: Yellow Powder

Peso molecular: 348.35g/mol

Ref: 54-OR014824

Camptothecin

CAS: 7689-03-4

Natural alkaloid

Fórmula: C₂₀H₁₆N₂O₄

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 348.36

Ref: 5G-89593

(S)-(+)-Camptothecin

Producto controlado

CAS: 7689-03-4

Impurity Topotecan USP Related Compound C
Applications Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Potmesil, M., et al.: Cancer Res., 54, 1431 (1994), Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997), Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998), Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998),

Fórmula: C₂₀H₁₆N₂O₄

Forma y color: Beige To Yellow

Peso molecular: 348.35

Ref: TR-C175150

Irinotecan EP Impurity D

CAS: 7689-03-4

Fórmula: C₂₀H₁₆N₂O₄

Peso molecular: 348.36

Ref: ST-EA-CP-I9028

(S)-(+)-Camptothecin

CAS: 7689-03-4

(S)-(+)-Camptothecin is a natural alkaloid compound, which is an extract from the Camptotheca acuminata tree. This natural source underlines the compound's origin, emphasizing its role in nature’s diverse chemistry. The primary mode of action of (S)-(+)-Camptothecin involves the inhibition of DNA topoisomerase I, an enzyme essential for DNA replication. By stabilizing the transient DNA-enzyme complex, it induces DNA damage, ultimately leading to apoptosis in rapidly dividing cells.

Fórmula: C₂₀H₁₆N₂O₄

Pureza: Min. 98 Area-%

Forma y color: Yellow Powder

Peso molecular: 348.35 g/mol

Ref: 3D-FC15450

Camptothecin

CAS: 7689-03-4

M01564 - Camptothecin

Fórmula: C₂₀H₁₆N₂O₄

Pureza: 98%

Forma y color: Solid, Crystalline Powder

Peso molecular: 348.358

Ref: 10-M01564

Camptothecin

CAS: 7689-03-4

Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.

Fórmula: C₂₀H₁₆N₂O₄

Pureza: 99.52% - 99.88%

Forma y color: Solid Powder

Peso molecular: 348.35

Ref: TM-T1123