CAS 7689-03-4
:Camptotecina
Descripción:
Camptotecina es un alcaloide que se encuentra de forma natural y se deriva de la corteza del árbol chino Camptotheca acuminata. Se clasifica como un inhibidor de la topoisomerasa I, lo que significa que interfiere con la enzima responsable de la replicación y transcripción del ADN, lo que lleva, en última instancia, a la muerte celular, particularmente en células cancerosas que se dividen rápidamente. Camptotecina exhibe una estructura compleja caracterizada por un sistema de anillo pentacíclico, que es crucial para su actividad biológica. El compuesto es conocido por sus potentes propiedades antitumorales y ha sido la base para el desarrollo de varios derivados semisintéticos, como el irinotecán y el topotecán, que se utilizan en la terapia del cáncer. Camptotecina es relativamente insoluble en agua pero soluble en disolventes orgánicos, lo que puede presentar desafíos para su formulación y entrega en entornos clínicos. Su farmacocinética y perfil de toxicidad son consideraciones importantes en su aplicación terapéutica, ya que puede causar efectos secundarios como mielosupresión y trastornos gastrointestinales. En general, Camptotecina sigue siendo un compuesto significativo en la investigación y tratamiento del cáncer.
Fórmula:C20H16N2O4
InChI:InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
Clave InChI:InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N
SMILES:C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=CC5)COC1=O
Sinónimos:- (+)-Camptothecin
- (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (S)-Camptothecin
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
- 20(S)-Camptothecin
- 20(S)-Camptothecine
- 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- Campathecin
- Campothecin
- Camptothccin
- Camptothecin, Camptotheca acuminata
- Mag-Cpt
- N-cyclohexyl-9-pentofuranosyl-9H-purin-6-amine
- Nsc 94600
- S-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- S-Ckd 602
- d-Camptothecin
- Ver más sinónimos
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Pureza (%)
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100
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100
Se han encontrado 17 productos.
(S)-(+)-Camptothecin
CAS:Fórmula:C20H16N2O4Pureza:>97.0%(HPLC)Forma y color:White to Yellow to Green powder to crystalPeso molecular:348.36Topotecan Related Compound C ((S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
CAS:Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoiFórmula:C20H16N2O4Forma y color:PowderPeso molecular:348.11101(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
CAS:Fórmula:C20H16N2O4Pureza:98%Forma y color:SolidPeso molecular:348.3520(S)-(+)-Camptothecin
CAS:(S)-(+)-CamptothecinFórmula:C20H16N2O4Pureza:98% (Typical Value in Batch COA)Forma y color:Yellow Solid-PowderPeso molecular:348.35203(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS:(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dioneFórmula:C20H16N2O4Pureza:≥95%Forma y color:Yellow Solid-PowderPeso molecular:348.35203(S)-(+)-Camptothecin
CAS:Fórmula:C20H16N2O4Pureza:≥ 95.0%Forma y color:Light-yellow to brown crystalline powderPeso molecular:348.35Camptothecin
CAS:Natural alkaloidFórmula:C20H16N2O4Pureza:≥ 90.0 % (HPLC)Forma y color:PowderPeso molecular:348.36(S)-(+)-Camptothecin
CAS:Producto controladoImpurity Topotecan USP Related Compound C
Applications Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Potmesil, M., et al.: Cancer Res., 54, 1431 (1994), Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997), Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998), Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998),Fórmula:C20H16N2O4Forma y color:NeatPeso molecular:348.35(S)-(+)-Camptothecin
CAS:(S)-(+)-Camptothecin is a natural alkaloid compound, which is an extract from the Camptotheca acuminata tree. This natural source underlines the compound's origin, emphasizing its role in nature’s diverse chemistry. The primary mode of action of (S)-(+)-Camptothecin involves the inhibition of DNA topoisomerase I, an enzyme essential for DNA replication. By stabilizing the transient DNA-enzyme complex, it induces DNA damage, ultimately leading to apoptosis in rapidly dividing cells.Fórmula:C20H16N2O4Pureza:Min. 98 Area-%Forma y color:Yellow PowderPeso molecular:348.35 g/molCamptothecin
CAS:M01564 - Camptothecin
Fórmula:C20H16N2O4Pureza:98%Forma y color:Solid, Crystalline PowderPeso molecular:348.358Camptothecin
CAS:Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Fórmula:C20H16N2O4Pureza:99.52% - 99.88%Forma y color:Solid PowderPeso molecular:348.35
![Topotecan Related Compound C ((S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F45%2Fthumb%2F1672280.jpg&w=3840&q=75)
![(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA003BCG.jpg&w=3840&q=75)
![(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR014824.jpg&w=3840&q=75)
