CAS 78832-65-2

N-(3-(2-furil)acrilol)-L-leucil-glicil-L-prolil-L-alanina

Descripción:

N-(3-(2-furil)acrilol)-L-leucil-glicil-L-prolil-L-alanina, con el número CAS 78832-65-2, es un derivado de péptido sintético que incorpora tanto secuencias de aminoácidos como un moiety basado en furanos. Este compuesto presenta una estructura única que combina las propiedades de un péptido con las de un acrilamida, lo que puede conferirle reactividad específica y actividad biológica. La presencia del anillo de furanos sugiere un potencial para interacciones con sistemas biológicos, posiblemente influyendo en sus propiedades farmacológicas. Los componentes de aminoácidos—L-leucina, glicina, L-prolina y L-alanina—contribuyen a la estabilidad y solubilidad del compuesto, al tiempo que afectan sus características conformacionales. Tales péptidos pueden exhibir diversas actividades biológicas, incluyendo efectos antimicrobianos, anticancerígenos o inhibitorios de enzimas, dependiendo de su estructura y de las interacciones específicas en las que se involucren. En general, este compuesto representa una fascinante intersección de la química orgánica y la bioquímica, con aplicaciones potenciales en el desarrollo de fármacos y la investigación terapéutica.

Fórmula: C₂₃H₃₂N₄O₇

InChI: InChI=1/C23H32N4O7/c1-14(2)12-17(26-19(28)9-8-16-6-5-11-34-16)21(30)24-13-20(29)27-10-4-7-18(27)22(31)25-15(3)23(32)33/h5-6,8-9,11,14-15,17-18H,4,7,10,12-13H2,1-3H3,(H,24,30)(H,25,31)(H,26,28)(H,32,33)/b9-8+/t15-,17-,18-/m0/s1

Clave InChI: ZLFQNOJSYZSINX-PVJKAEHXSA-N

SMILES: C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)/C=C/C2=CC=CO2

Sinónimos:

• N-(3-(2-furyl)acryloyl)-leu-gly-pro-ala
• FA-Leu-Gly-Pro-Ala-OH
• Falgpa
• N-[(2E)-3-furan-2-ylprop-2-enoyl]-L-leucylglycyl-L-prolyl-L-alanine
• COLLAGENASE CELL PREPARATION GRADE
• COLLAGENASE GRADE II
• COLLAGENASE GRADE I
• clostridiopeptidase
• CollagenaseⅡ
• N-[3-(2-FURYL)ACRYLOYL]-L-LEUCYL-GLYCYL-L-PROLYL-L-ALANINE
• (2S)-3-{2-[(1E)-2-{[(1S)-1-({2-[(2S)-2-{[(1S)-1-carboxyethyl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl}carbamoyl)-3-methylbutyl]carbamoyl}eth-1-en-1-yl]-1λ3-furan-1-yl}-2-{[(2S)-1-{2-[(2S)-2-[(2E)-3-(furan-2-yl)prop-2-enamido]-4-methylpentanamido]acetyl}pyrro
• N-[3-(2-furyl)acryloyl]-leucine-glycine-proline-alanine
• N-(3-(2-FURYL)ACRYLOYL)-L-LEUCYL-GLYCYL&
• N-{3-(2-Furyl)acryloyl}-L-leucine-glycyl-L-propyl-L-alanine
• FALGPA, N-[3-(2-Furyl)acryloyl]-L-leucyl-glycyl-L-prolyl-L-alanine
• COLLAGENASE SUBSTRATE II
• COLLAGENASE HIGHLY PURIFIED
• CollagenaseⅠ
• CollagenaseⅤ
• CollagenaseⅣ
• 2-furanacryloyl-leucyl-glycyl-prolyl-alanine
• COLLAGENASE (CLOSTRIDIOPEPTIDASE A)

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

Substrate for a versatile, convenient, continuously recording spectrophotometric assay of collagenase.

Fórmula: C₂₃H₃₂N₄O₇

Pureza: 97.7%

Forma y color: Beige

Peso molecular: 476.53

Ref: 01-4006713

FALGPA

CAS: 78832-65-2

FALGPA

Fórmula: C₂₃H₃₂N₄O₇

Pureza: By hplc: >98% by area (Typical Value in Batch COA)

Forma y color: White Solid-Powder

Peso molecular: 476.52277

Ref: 54-BIF0744

FA-Leu-Gly-Pro-Ala-O

CAS: 78832-65-2

FA-Leu-Gly-Pro-Ala-OH is a synthetic peptide and a specific collagenase substrate, widely used in biochemical experiments and drug synthesis research.

Fórmula: C₂₃H₃₂N₄O₇

Pureza: 99.90%

Forma y color: Solid

Peso molecular: 476.52

Ref: TM-T205939

(3-(Furan-2-yl)acryloyl)-L-leucylglycyl-L-prolyl-L-alanine

CAS: 78832-65-2

Fórmula: C₂₃H₃₂N₄O₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 476.5228

Ref: IN-DA005DFG

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

(3-(Furan-2-yl)acryloyl)-L-leucylglycyl-L-prolyl-L-alanine

Fórmula: C₂₃H₃₂N₄O₇

Pureza: 98%

Peso molecular: 476.52

Ref: IN-DG129969

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

FA-Leu-Gly-Pro-Ala-OH is a gelatinase inhibitor that inhibits the action of collagenase, an enzyme that breaks down collagen. It has been shown to inhibit the growth of cancer cells in vitro and may be useful as a therapeutic agent against skin cancer. FA-Leu-Gly-Pro-Ala-OH binds to the active site of the enzyme and blocks its catalytic activity by preventing proton transfer during the hydrolysis of peptide bonds. This inhibitor also has proteolytic properties, which are due to its ability to cleave proteins with basic amino acids such as arginine and lysine. The inhibitory effects of FA-Leu-Gly-Pro-Ala-OH on histological analysis were also tested on fibroblast cells with collagenase activity, which showed a significant reduction in enzyme activity after incubation with this inhibitor.

Fórmula: C₂₃H₃₂N₄O₇

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 476.52 g/mol

Ref: 3D-FF110857