CAS 83784-20-7

Hidrocortisona hemisuccinato hidratado

Descripción:

Hidrocortisona hemisuccinato hidratado es un derivado sintético de la hidrocortisona, una hormona corticosteroide. Se caracteriza por su forma de éster hemisuccinato, que mejora su solubilidad y biodisponibilidad en comparación con el compuesto original. Esta sustancia aparece típicamente como un polvo cristalino blanco a blanco sucio y es higroscópica, lo que significa que puede absorber humedad del ambiente. Se utiliza a menudo en formulaciones farmacéuticas, particularmente por sus propiedades antiinflamatorias e inmunosupresoras. El compuesto es soluble en agua y exhibe estabilidad bajo condiciones de almacenamiento adecuadas. Hidrocortisona hemisuccinato hidratado se utiliza comúnmente en formulaciones inyectables, lo que lo hace valioso en entornos clínicos para tratar diversas condiciones, incluidas reacciones alérgicas y enfermedades inflamatorias. Sus efectos farmacológicos son mediado principalmente a través de la modulación de la expresión génica y la inhibición de citoquinas proinflamatorias. Al igual que con todos los corticosteroides, su uso debe ser cuidadosamente monitoreado para evitar posibles efectos secundarios asociados con la administración a largo plazo.

Fórmula: C₂₅H₃₆O₉

InChI: InChI=1S/C25H34O8.H2O/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);1H2/t16-,17-,18-,22+,23-,24-,25-;/m0./s1

Clave InChI: AFLWPAGYTPJSEY-CODXZCKSSA-N

SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)O)O)C)O.O

Sinónimos:

• (11b-)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione monohydrate
• HYDROCORTISONEHEMISUCCINATE,MONOHYDRATE,USP
• 11β,17aα,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate
• Hydrocortisone Hemisuccinate (200 mg)
• 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid hydrate
• 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]-4-oxo-butanoic acid hydrate
• Hydrocortisone 21-hemisuccinat
• Hydrocortisone hemisuccinate hydrate USP/EP/BP
• HYDROCORTISONE HEMISUCCINATE, MONOHYDRATE
• 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-3-keto-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-keto-ethoxy]-4-keto-butyric acid hydrate
• Hydrocortisone hemisuccinate hydrate
• CORTISOL HEMISUCCINATE MONOHYDRATE

HYDROCORTISONE HYDROGEN SUCCINATE CRS

CAS: 83784-20-7

HYDROCORTISONE HYDROGEN SUCCINATE CRS

Fórmula: C₂₅H₃₄O₈

Forma y color: Powder

Peso molecular: 462.5327

Ref: 41-H1425000

Hydrocortisone Hemisuccinate

CAS: 83784-20-7

Adrenal cortical hormones and their derivatives nesoi

Fórmula: C₂₅H₃₄O₈·H₂O

Forma y color: White Off-White Powder

Peso molecular: 462.22537

Ref: 45-1319002

Hydrocortisone hemisuccinate hydrate

CAS: 83784-20-7

Hydrocortisone hemisuccinate hydrate

Fórmula: C₂₅H₃₆O₉

Pureza: 97%

Peso molecular: 480.55

Ref: 54-OR1109458

Hydrocortisone hemisuccinate hydrate

CAS: 83784-20-7

Fórmula: C₂₅H₃₆O₉

Pureza: 97%

Forma y color: Solid

Peso molecular: 480.5479

Ref: IN-DA00IDBT

Hydrocortisone Hemisuccinate Hydrate

Producto controlado

CAS: 83784-20-7

Applications Hydrocortisone Hemisuccinate Hydrate is a metabolite of Hydrocortisone (H714615), a steroid hormone, specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids.
References Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009);

Fórmula: C₂₅H₃₄O₈·H₂O

Forma y color: Neat

Peso molecular: 480.55

Ref: TR-H714765

Hydrocortisone succinate monohydrate

CAS: 83784-20-7

Fórmula: C₂₅H₃₆O₉

Peso molecular: 480.5

Ref: BE-BePure-26380

Hydrocortisone hemisuccinate

Producto controlado

CAS: 83784-20-7

Hydrocortisone hemisuccinate is a corticosteroid that belongs to the group of glucocorticoids. It is used in the treatment of bowel disease, such as ulcerative colitis and Crohn's disease. Hydrocortisone hemisuccinate has been shown to have chemical stability in biological reaction solutions and has an anti-inflammatory activity in animal models. The drug has minimal effects on the maternal blood system and does not produce any significant drug interactions when combined with other drugs. Hydrocortisone hemisuccinate also does not cause allergic symptoms or receptor activity, unlike other corticosteroids such as dexamethasone. This steroid is used for the treatment of erythropoietic protoporphyria, which is a rare disorder where the skin becomes sensitive to sunlight. Hydrocortisone hemisuccinate can be administered at physiological levels and this form of hydrocortisone provides sodium salts as a

Fórmula: C₂₅H₃₄O₈·H₂O

Pureza: Min. 95%

Peso molecular: 480.55 g/mol

Ref: 3D-IDA78420

Hydrocortisone Hemisuccinate Hydrate

CAS: 83784-20-7

Fórmula: C₂₅H₃₄O₈H₂O

Peso molecular: 462.54 : 18.02

Ref: ST-EA-CP-H9119