CAS 86639-52-3

7-etil-10-hidroxicamptotecina

Descripción:

7-etil-10-hidroxicamptotecina, con el número CAS 86639-52-3, es un derivado de la camptotecina, un compuesto originalmente aislado de la corteza del árbol chino Camptotheca acuminata. Esta sustancia se caracteriza por sus modificaciones estructurales, que mejoran sus propiedades farmacológicas. Exhibe una potente actividad antitumoral, principalmente a través de su mecanismo de acción como inhibidor de la topoisomerasa I, interrumpiendo los procesos de replicación y transcripción del ADN en las células cancerosas. El compuesto es típicamente un sólido amarillo pálido y es soluble en disolventes orgánicos como el dimetilsulfóxido (DMSO), pero tiene una solubilidad limitada en agua. Su potencial terapéutico ha sido explorado en varios tratamientos contra el cáncer, particularmente para tumores sólidos. Sin embargo, al igual que muchos agentes quimioterapéuticos, puede presentar efectos secundarios, incluida la toxicidad para las células normales. La investigación continúa para optimizar su eficacia y minimizar los efectos adversos, convirtiéndolo en un tema de interés en química medicinal y oncología.

Fórmula: C₂₂H₂₀N₂O₅

InChI: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1

Clave InChI: InChIKey=FJHBVJOVLFPMQE-QFIPXVFZSA-N

SMILES: C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5

Sinónimos:

• (19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (S)-Sn 38
• 10-Hydroxy-7-ethylcamptothecin
• 1H-Pyrano3,4:6,7Indolizino1,2-Bquinoline-3,14(4H,12H)-Dione, 4-Ethyl-4,10-Dihydroxy-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)-
• 4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
• 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 7-Ethyl-10-Hydroxy Camptothecin
• 7-Ethyl-10-Hydroxy-Camptothecine
• 7-Ethyl-10-hydroxy-20(S)-camptothecin
• 7-Ethyl-10-hydroxycamptothecine
• Intermediate of Irinotecan 1
• SN 38 (pharmaceutical)
• SN 38 lactone
• Sn-38

7-Ethyl-10-hydroxycamptothecin

CAS: 86639-52-3

Fórmula: C₂₂H₂₀N₂O₅

Pureza: >98.0%(HPLC)

Forma y color: White to Yellow to Green powder to crystal

Peso molecular: 392.41

Ref: 3B-E0748

Irinotecan Related Compound B ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS: 86639-52-3

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

Fórmula: C₂₂H₂₀N₂O₅

Forma y color: Yellow Off-White Powder

Peso molecular: 392.13722

Ref: 45-1347631

7-Ethyl-10-hydroxycamptothecin

CAS: 86639-52-3

Fórmula: C₂₂H₂₀N₂O₅

Pureza: ≥ 98.0%

Forma y color: Off-white to yellow powder

Peso molecular: 392.40

Ref: 7W-GP6652

Irinotecan EP Impurity E (Irinotecan USP Related Compound B, (S)-7-Ethyl-10-Hydroxy Camptothecin)

CAS: 86639-52-3

Fórmula: C₂₂H₂₀N₂O₅

Forma y color: Pale Yellow Solid

Peso molecular: 392.41

Ref: 4Z-I-1818

SN-38

CAS: 86639-52-3

SN-38

Pureza: ≥98%

Peso molecular: 392.4g/mol

Ref: 54-BUP14103

7-Ethyl-10-hydroxycamptothecin ((S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS: 86639-52-3

Forma y color: Neat

Ref: 86-MM1157.01

7-Ethyl-10-Hydroxycamptothecin

CAS: 86639-52-3

Fórmula: C₂₂H₂₀N₂O₅

Pureza: 95%~99%

Peso molecular: 392.411

Ref: BP-BP0099

SN-38

CAS: 86639-52-3

SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).

Fórmula: C₂₂H₂₀N₂O₅

Pureza: 98% - 99.97%

Forma y color: Light-Yellow Solid

Peso molecular: 392.4

Ref: TM-T1703

SN-38

CAS: 86639-52-3

Fórmula: C₂₂H₂₀N₂O₅

Forma y color: Light Yellow To Yellow

Peso molecular: 392.40

Ref: TR-S589950

Irinotecan EP Impurity E

CAS: 86639-52-3

Fórmula: C₂₂H₂₀N₂O₅

Peso molecular: 392.41

Ref: ST-EA-CP-I9005

7-Ethyl-10-hydroxycamptothecin

CAS: 86639-52-3

7-Ethyl-10-hydroxycamptothecin (also known as SN38) is a metabolite of irinotecan hydrochloride (CPT-11). SN38 is a topoisomerase I inhibitor and has potential applications as an anti-tumour agent however its water insolubility presents challenges in terms of bioavailability. Topoisomerase I relaxes the tightly bound DNA double helix and breaks one DNA strand to allow for DNA replication, the topoisomerase-DNA complex is short-lived and once DNA replication is complete topoisomerase reforms the DNA strand. SN38 prolongs the lifetime of the topoisomerase I-DNA complex and inhibits the DNA reforming step, as a result cleavage of the second DNA strand can occur leading to cell death.

Fórmula: C₂₂H₂₀N₂O₅

Pureza: Min. 98 Area-%

Forma y color: Off-White Yellow Powder

Peso molecular: 392.4 g/mol

Ref: 3D-FE29579

7-Ethyl-10-hydroxy-camptothecin

CAS: 86639-52-3

Fórmula: C₂₂H₂₀N₂O₅

Pureza: 98%

Forma y color: Yellow powder

Peso molecular: 392.411

Ref: 10-F046379

SN-38-13C3

Producto controlado

CAS: 86639-52-3

Fórmula: C₃C₁₉H₂₀N₂O₅

Forma y color: Neat

Peso molecular: 395.383

Ref: TR-S589954

SN-38-d5

Producto controlado

CAS: 86639-52-3

Fórmula: C₂₂D₅H₁₅N₂O₅

Forma y color: Neat

Peso molecular: 397.435

Ref: TR-S589953