CAS 86639-52-3
:7-etil-10-hidroxicamptotecina
Descripción:
7-etil-10-hidroxicamptotecina, con el número CAS 86639-52-3, es un derivado de la camptotecina, un compuesto originalmente aislado de la corteza del árbol chino Camptotheca acuminata. Esta sustancia se caracteriza por sus modificaciones estructurales, que mejoran sus propiedades farmacológicas. Exhibe una potente actividad antitumoral, principalmente a través de su mecanismo de acción como inhibidor de la topoisomerasa I, interrumpiendo los procesos de replicación y transcripción del ADN en las células cancerosas. El compuesto es típicamente un sólido amarillo pálido y es soluble en disolventes orgánicos como el dimetilsulfóxido (DMSO), pero tiene una solubilidad limitada en agua. Su potencial terapéutico ha sido explorado en varios tratamientos contra el cáncer, particularmente para tumores sólidos. Sin embargo, al igual que muchos agentes quimioterapéuticos, puede presentar efectos secundarios, incluida la toxicidad para las células normales. La investigación continúa para optimizar su eficacia y minimizar los efectos adversos, convirtiéndolo en un tema de interés en química medicinal y oncología.
Fórmula:C22H20N2O5
InChI:InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
Clave InChI:InChIKey=FJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILES:C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5
Sinónimos:- (19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
- (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (S)-Sn 38
- 10-Hydroxy-7-ethylcamptothecin
- 1H-Pyrano3,4:6,7Indolizino1,2-Bquinoline-3,14(4H,12H)-Dione, 4-Ethyl-4,10-Dihydroxy-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)-
- 4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
- 4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 7-Ethyl-10-Hydroxy Camptothecin
- 7-Ethyl-10-Hydroxy-Camptothecine
- 7-Ethyl-10-hydroxy-20(S)-camptothecin
- 7-Ethyl-10-hydroxycamptothecine
- Intermediate of Irinotecan 1
- SN 38 (pharmaceutical)
- SN 38 lactone
- Sn-38
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Se han encontrado 16 productos.
Irinotecan Related Compound B ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
CAS:Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoiFórmula:C22H20N2O5Forma y color:Yellow Off-White PowderPeso molecular:392.13722Irinotecan EP Impurity E (Irinotecan USP Related Compound B, (S)-7-Ethyl-10-Hydroxy Camptothecin, SN-38)
CAS:Fórmula:C22H20N2O5Forma y color:Pale Yellow SolidPeso molecular:392.417-Ethyl-10-hydroxycamptothecin
CAS:Fórmula:C22H20N2O5Pureza:≥ 98.0%Forma y color:Off-white to yellow powderPeso molecular:392.40SN-38
CAS:(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dioneFórmula:C22H20N2O5Pureza:98%Peso molecular:392.4SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Fórmula:C22H20N2O5Pureza:98% - 99.97%Forma y color:Yellow SolidPeso molecular:392.407-Ethyl-10-hydroxy-camptothecin
CAS:Fórmula:C22H20N2O5Pureza:98%Forma y color:SolidPeso molecular:392.4117-Ethyl-10-hydroxycamptothecin
CAS:Fórmula:C22H20N2O5Pureza:>98.0%(HPLC)Forma y color:White to Yellow to Green powder to crystalPeso molecular:392.417-Ethyl-10-hydroxycamptothecin
CAS:7-Ethyl-10-hydroxycamptothecin (also known as SN38) is a metabolite of irinotecan hydrochloride (CPT-11). SN38 is a topoisomerase I inhibitor and has potential applications as an anti-tumour agent however its water insolubility presents challenges in terms of bioavailability. Topoisomerase I relaxes the tightly bound DNA double helix and breaks one DNA strand to allow for DNA replication, the topoisomerase-DNA complex is short-lived and once DNA replication is complete topoisomerase reforms the DNA strand. SN38 prolongs the lifetime of the topoisomerase I-DNA complex and inhibits the DNA reforming step, as a result cleavage of the second DNA strand can occur leading to cell death.
Fórmula:C22H20N2O5Pureza:Min. 98 Area-%Forma y color:Off-White Yellow PowderPeso molecular:392.4 g/molRef: 3D-FE29579
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