CAS 9002-96-4

succinato de polietilenglicol de α-tocoferilo

Descripción:

succinato de polietilenglicol de α-tocoferilo, comúnmente conocido como TPGS, es un derivado sintético de la vitamina E (α-tocoferol) que se utiliza ampliamente en formulaciones farmacéuticas y cosméticas. Se caracteriza por su naturaleza anfifílica, que le permite funcionar como un tensioactivo y solubilizante, mejorando la biodisponibilidad de fármacos poco solubles. TPGS es conocido por su capacidad para mejorar la estabilidad de las formulaciones y también puede actuar como un antioxidante debido a la presencia de la parte de tocoferol. Su componente de polietilenglicol (PEG) contribuye a su hidrofobicidad, facilitando la formación de micelas y mejorando los sistemas de entrega de fármacos. Además, TPGS es reconocido por su biocompatibilidad y baja toxicidad, lo que lo hace adecuado para diversas aplicaciones, incluyendo la entrega de fármacos orales, parenterales y tópicos. Sus propiedades únicas le permiten ser utilizado en una variedad de industrias, desde farmacéuticas hasta cosméticas, donde puede mejorar el rendimiento y la eficacia del producto.

Fórmula: (C₂H₄O)nC₃₃H₅₄O₅

InChI: InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3

Clave InChI: InChIKey=AOBORMOPSGHCAX-UHFFFAOYSA-N

SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(c(C)c(C)c2O1)OC(=O)CCC(=O)OCCO

Sinónimos:

• 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl butanedioate
• <span class="text-smallcaps">D</span>-α-Tocopherol acid polyethylene glycol 1000 succinate
• <span class="text-smallcaps">D</span>-α-Tocopherol polyethylene glycol 1000 succinate
• <span class="text-smallcaps">D</span>-α-Tocopheryl polyethylene glycol succinate
• Eastman Vitamin ETPGS
• Ethoxylated vitamin E succinate
• Kolliphor TPGS
• Mono[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl] succinate, polyoxyethylene ether
• Poly(oxy-1,2-ethanediyl), α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-
• Poly(oxy-1,2-ethanediyl), α-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-, [2R-[2R*(4R*,8R*)]]-
• Polyethylene glycol vitamin E succinate
• Speziol TPGS Pharma
• Tocophersolan
• Tpgs 1000
• Tpgs 1500
• Tpgs 400-1000
• Tpgs-Ve
• Ve-Tpgs 1000
• Vedrop
• VitE-TPGS
• Vitamin E-TPGS
• d-α-Tocopheryl poly(ethylene glycol) 1000 succinate
• d-α-Tocopheryl polyethylene glycol succinate
• α-Tocopherol polyethylene glycol succinate
• α-Tocopheryl polyethylene glycol succinate
• D-α-Tocopherol polyethylene glycol 1000 succinate

alpha-Tocopherol Polyethylene Glycol Succinate

CAS: 9002-96-4

Forma y color: White or Colorless to Yellow powder to lump to clear liquid

Ref: 3B-T3118

Tocofersolan

CAS: 9002-96-4

Tocofersolan

Fórmula: C₃₉H₆₆O₈

Pureza: ≥98%

Peso molecular: 662.95

Ref: 54-BUP23660

D-α-Tocopherol polyethylene glycol 1000 succinate, USP/NF grade

CAS: 9002-96-4

Forma y color: White to light-brown powder or waxy solid

Ref: 7W-GK2110

D-α-Tocopherol polyethylene glycol succinate

CAS: 9002-96-4

Pureza: ≥ 25.0% (D-Alpha Tocopherol)

Forma y color: White to light-brown powder or waxy solid

Peso molecular: -

Ref: 7W-GK2339

Tocofersolan

CAS: 9002-96-4

Applications Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
References Socha, P. et al.: J. Pediatric Gastroenterol. Nutr., 24, 189 (1997); Chang, T. et al.: Clin. Pharmacol. Therap., 59, 297 (1996); Wu, S.H.W. et al.: Pharmac. Technol., 23, 52 (1999);

Fórmula: C₃₃H₅₄O₅(C₂H₄O)n

Forma y color: Neat

Peso molecular: 574.83

Ref: TR-T526075

Tocofersolan

CAS: 9002-96-4

Tocofersolan (TPGS) treats vitamin E deficiency in pediatric digestive malabsorption.

Fórmula: (C₂H₄O)nC₃₃H₅₄O₅

Pureza: ≥98%

Forma y color: Solid

Peso molecular: 662.949

Ref: TM-T4994

Tocofersolan

CAS: 9002-96-4

α-Tocopherol Polyethylene Glycol Succinate

Fórmula: (C₂H₄O)nC₃₃H₅₄O₅

Peso molecular: 0.0

Ref: IN-DG126456

α-Tocopherol Polyethylene Glycol Succinate

CAS: 9002-96-4

Fórmula: C₃₃H₅₄O₅(C₂H₄O)n

Peso molecular: 530.79)( 44.05)n

Ref: ST-EA-CP-T94007

D-alpha-Tocopheryl polyethylene glycol succinate

CAS: 9002-96-4

D-alpha-Tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that is active in inhibiting chronic myeloid leukemia. TPGS has been shown to be effective against the resistant K562 cells and may be used as a treatment for chronic myeloid leukemia. This drug binds to the enzyme urokinase-type plasminogen activator, which is essential for cancer cell migration and invasion of tumor tissue. It also inhibits tyrosine kinase, which plays an important role in the development of cancer cells by regulating cellular growth and proliferation. TPGS has been shown to have low bioavailability in humans and is not detectable in plasma after oral administration.

Fórmula: C₃₃H₅₄O₅•(C₂H₄O)n

Pureza: Min. 25.0%

Forma y color: White Slightly Brown Solidified Mass

Ref: 3D-FT40328