CAS 90332-63-1
:7-Xilosil-10-desacetiltaxol
Descripción:
7-Xilosil-10-desacetiltaxol, identificado por su número CAS 90332-63-1, es un compuesto químico derivado de la familia de los taxanos, conocido por su papel significativo en el tratamiento del cáncer, particularmente en la formulación de agentes quimioterapéuticos como el paclitaxel. Este compuesto presenta un grupo de azúcar xilosilo unido a la estructura del taxano, lo que puede influir en su solubilidad, estabilidad y actividad biológica. La presencia del grupo deacetilo sugiere que puede exhibir diferentes propiedades farmacológicas en comparación con sus contrapartes acetiladas. En general, los taxanos se caracterizan por su capacidad para inhibir la despolimerización de microtúbulos, interrumpiendo así la división celular normal, que es un mecanismo crítico en la terapia del cáncer. Las características específicas de 7-Xilosil-10-desacetiltaxol, incluyendo su peso molecular, solubilidad y actividad biológica, serían esenciales para entender sus posibles aplicaciones terapéuticas y eficacia. Se necesitarían más estudios para elucidar su farmacocinética, toxicidad y papel general en la química medicinal.
Fórmula:C50H57NO17
InChI:InChI=1S/C50H57NO17/c1-25-31(65-45(61)38(56)35(27-15-9-6-10-16-27)51-43(59)28-17-11-7-12-18-28)22-50(62)42(67-44(60)29-19-13-8-14-20-29)40-48(5,41(58)37(55)34(25)47(50,3)4)32(21-33-49(40,24-64-33)68-26(2)52)66-46-39(57)36(54)30(53)23-63-46/h6-20,30-33,35-40,42,46,53-57,62H,21-24H2,1-5H3,(H,51,59)/t30-,31+,32+,33-,35+,36+,37-,38-,39-,40+,42+,46+,48-,49+,50-/m1/s1
Clave InChI:InChIKey=ORKLEZFXASNLFJ-DYLQFHMVSA-N
SMILES:O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)C[C@]1(OC2)[H])C(=O)[C@H](O)C=5C(C)(C)[C@](O)([C@H]3OC(=O)C6=CC=CC=C6)C[C@H](OC([C@@H]([C@@H](NC(=O)C7=CC=CC=C7)C8=CC=CC=C8)O)=O)C5C)[H]
Sinónimos:- 10-Deacetyl-7-xylosylpaclitaxel
- 10-Deacetyl-7-xylosyltaxol
- 10-Deacetylpaclitaxel 7-xyloside
- 10-Deacetyltaxol 7-xyloside
- 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
- 7-Xylosyl-10-deacetylpaclitaxel
- 7β-Xylosyl-10-deacetyltaxol
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
- b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
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Encontrado 11 productos.
Benzenepropanoic acid, b-(benzoylamino)-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS)-
CAS:Fórmula:C50H57NO17Pureza:98%Forma y color:SolidPeso molecular:943.984110-Deacetyl-7-xylosyl paclitaxel
CAS:10-Deacetyl-7-xylosyl paclitaxelPureza:≥95%Peso molecular:943.98g/mol10-Deacetyl-7-Xylosylpaclitaxel
CAS:Fórmula:C50H57NO17Forma y color:White To Off-White SolidPeso molecular:944.0010-Deacetyl-7-xylosyl paclitaxel
CAS:10-Deacetyl-7-xylosyl paclitaxel has long been used in Chinese clinics to treat cancer, it may target mitochondrial permeability transition pore (mPTP).Fórmula:C50H57NO17Pureza:95%~99%Peso molecular:943.99610-Deacetyl-7-xylosyl paclitaxel
CAS:<p>10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility.</p>Fórmula:C50H57NO17Pureza:99.76% - ≥95%Forma y color:SolidPeso molecular:943.9810-Deacetyl-7-xylosyl Paclitaxel (62%)
CAS:Producto controlado<p>Impurity Paclitaxel - In House Impurity<br>Stability Hygroscopic<br>Applications A metabolite of Paclitaxel (P132500). Paclitaxel - In House Impurity.<br>References Gut, I., et al.: Xenobiotica, 36, 772 ( 2006), Zhang, J., et al.: Drug Metab. Dispos., 36, 418 (2008), Li, S., et al.: J. Pharm. Biomed. Anal., 49, 81, (2009),<br></p>Fórmula:C50H57NO17Pureza:62%Forma y color:NeatPeso molecular:943.987-Xylosyl-10-deacetyltaxol
CAS:<p>7-Xylosyl-10-deacetyltaxol is a plant chemical that is found in the needles of the Taxus cuspidata tree. This compound has been shown to inhibit prostate cancer cells and has been clinically used as an adjuvant agent for cancer treatment. 7-Xylosyl-10-deacetyltaxol binds to prostate cancer cells and inhibits their growth, which may be due to its ability to inhibit cell cycle progression at the G2/M phase transition. It also has a strong inhibitory effect on test samples from human prostate cancer cells. In addition, it inhibits enzyme activities that are involved in the biosynthesis of membrane lipids, such as phospholipase A2, arachidonate 12-lipoxygenase, and cyclooxygenase 2. 7-Xylosyl-10-deacetyltaxol also inhibits enzyme activities in cell culture that are involved in the synthesis of carbon</p>Fórmula:C50H57NO17Pureza:Min. 95%Peso molecular:943.98 g/mol
