CAS 90332-63-1

7-Xilosil-10-desacetiltaxol

Descripción:

7-Xilosil-10-desacetiltaxol, identificado por su número CAS 90332-63-1, es un compuesto químico derivado de la familia de los taxanos, conocido por su papel significativo en el tratamiento del cáncer, particularmente en la formulación de agentes quimioterapéuticos como el paclitaxel. Este compuesto presenta un grupo de azúcar xilosilo unido a la estructura del taxano, lo que puede influir en su solubilidad, estabilidad y actividad biológica. La presencia del grupo deacetilo sugiere que puede exhibir diferentes propiedades farmacológicas en comparación con sus contrapartes acetiladas. En general, los taxanos se caracterizan por su capacidad para inhibir la despolimerización de microtúbulos, interrumpiendo así la división celular normal, que es un mecanismo crítico en la terapia del cáncer. Las características específicas de 7-Xilosil-10-desacetiltaxol, incluyendo su peso molecular, solubilidad y actividad biológica, serían esenciales para entender sus posibles aplicaciones terapéuticas y eficacia. Se necesitarían más estudios para elucidar su farmacocinética, toxicidad y papel general en la química medicinal.

Fórmula: C₅₀H₅₇NO₁₇

InChI: InChI=1S/C50H57NO17/c1-25-31(65-45(61)38(56)35(27-15-9-6-10-16-27)51-43(59)28-17-11-7-12-18-28)22-50(62)42(67-44(60)29-19-13-8-14-20-29)40-48(5,41(58)37(55)34(25)47(50,3)4)32(21-33-49(40,24-64-33)68-26(2)52)66-46-39(57)36(54)30(53)23-63-46/h6-20,30-33,35-40,42,46,53-57,62H,21-24H2,1-5H3,(H,51,59)/t30-,31+,32+,33-,35+,36+,37-,38-,39-,40+,42+,46+,48-,49+,50-/m1/s1

Clave InChI: InChIKey=ORKLEZFXASNLFJ-DYLQFHMVSA-N

SMILES: O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)C[C@]1(OC2)[H])C(=O)[C@H](O)C=5C(C)(C)[C@](O)([C@H]3OC(=O)C6=CC=CC=C6)C[C@H](OC([C@@H]([C@@H](NC(=O)C7=CC=CC=C7)C8=CC=CC=C8)O)=O)C5C)[H]

Sinónimos:

• 10-Deacetyl-7-xylosylpaclitaxel
• 10-Deacetyl-7-xylosyltaxol
• 10-Deacetylpaclitaxel 7-xyloside
• 10-Deacetyltaxol 7-xyloside
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7-Xylosyl-10-deacetylpaclitaxel
• 7β-Xylosyl-10-deacetyltaxol
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

7-Xylosyl-10-deacetyltaxol

CAS: 90332-63-1

Fórmula: C₅₀H₅₇NO₁₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 943.9841

Ref: IN-DA00IG3O

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

10-Deacetyl-7-xylosyl paclitaxel

Pureza: ≥95%

Peso molecular: 943.98g/mol

Ref: 54-OR1031587

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

Fórmula: C₅₀H₅₇NO₁₇

Peso molecular: 944.00

Ref: 7W-GY0774

10-Deacetyl-7-Xylosyl Paclitaxel

CAS: 90332-63-1

Fórmula: C₅₀H₅₇NO₁₇

Forma y color: White To Off-White Solid

Peso molecular: 944.00

Ref: 4Z-P-2863

10-O-Deacetyl-7-O-(β-xylosyl)paclitaxel

CAS: 90332-63-1

Forma y color: Neat

Ref: 86-MM1489.13

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

10-Deacetyl-7-xylosyl paclitaxel has long been used in Chinese clinics to treat cancer, it may target mitochondrial permeability transition pore (mPTP).

Fórmula: C₅₀H₅₇NO₁₇

Pureza: 95%~99%

Peso molecular: 943.996

Ref: BP-SBP03710

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility.

Fórmula: C₅₀H₅₇NO₁₇

Pureza: 99.76% - ≥95%

Forma y color: Solid

Peso molecular: 943.98

Ref: TM-T5749

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

Ref: BE-RMCP002056

10-Deacetyl-7-xylosyl Paclitaxel (62%)

Producto controlado

CAS: 90332-63-1

Impurity Paclitaxel - In House Impurity
Stability Hygroscopic
Applications A metabolite of Paclitaxel (P132500). Paclitaxel - In House Impurity.
References Gut, I., et al.: Xenobiotica, 36, 772 ( 2006), Zhang, J., et al.: Drug Metab. Dispos., 36, 418 (2008), Li, S., et al.: J. Pharm. Biomed. Anal., 49, 81, (2009),

Fórmula: C₅₀H₅₇NO₁₇

Pureza: 62%

Forma y color: Neat

Peso molecular: 943.98

Ref: TR-D198965

7-Xylosyl-10-deacetyltaxol

CAS: 90332-63-1

7-Xylosyl-10-deacetyltaxol is a plant chemical that is found in the needles of the Taxus cuspidata tree. This compound has been shown to inhibit prostate cancer cells and has been clinically used as an adjuvant agent for cancer treatment. 7-Xylosyl-10-deacetyltaxol binds to prostate cancer cells and inhibits their growth, which may be due to its ability to inhibit cell cycle progression at the G2/M phase transition. It also has a strong inhibitory effect on test samples from human prostate cancer cells. In addition, it inhibits enzyme activities that are involved in the biosynthesis of membrane lipids, such as phospholipase A2, arachidonate 12-lipoxygenase, and cyclooxygenase 2. 7-Xylosyl-10-deacetyltaxol also inhibits enzyme activities in cell culture that are involved in the synthesis of carbon

Fórmula: C₅₀H₅₇NO₁₇

Pureza: Min. 95%

Peso molecular: 943.98 g/mol

Ref: 3D-MX20833

10-Deacetyl-7-xylosyl Paclitaxel

CAS: 90332-63-1

Fórmula: C₅₀H₅₇NO₁₇

Peso molecular: 944.00

Ref: ST-EA-CP-P36087