CAS 903576-44-3
:clorhidrato de pitolisant
Descripción:
clorhidrato de pitolisant es un medicamento utilizado principalmente para el tratamiento de la narcolepsia, un trastorno del sueño caracterizado por somnolencia diurna excesiva y cataplexia. Funciona como un antagonista/inverso agonista selectivo del receptor H3 de histamina, lo que mejora la liberación de histamina y promueve la vigilia. La sustancia se administra típicamente en su forma de sal hidrocloruro, lo que mejora su solubilidad y estabilidad. El pitolisant tiene un perfil farmacocinético favorable, con una vida media relativamente larga, lo que permite una dosificación una vez al día. Generalmente es bien tolerado, aunque los efectos secundarios potenciales pueden incluir insomnio, ansiedad y trastornos gastrointestinales. La estructura química del pitolisant incluye un anillo de piperidina, que contribuye a su actividad farmacológica. Como una opción de tratamiento novedosa, representa un avance significativo en el manejo de la narcolepsia, proporcionando una alternativa a los medicamentos estimulantes tradicionales. Su desarrollo subraya la importancia de dirigirse a sistemas específicos de neurotransmisores para mejorar la vigilia y la calidad de vida en general de las personas afectadas por trastornos del sueño.
- Ciproxidine
- Bf2649
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Encontrado 7 productos.
Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-, hydrochloride
CAS:Fórmula:C17H27Cl2NOPureza:97%Forma y color:SolidPeso molecular:332.3084Pitolisant hydrochloride
CAS:Pitolisant hydrochloride (Ciproxidine) is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM).Fórmula:C17H27Cl2NOPureza:99.72% - 99.91%Forma y color:SolidPeso molecular:332.31Pitolisant hydrochloride
CAS:<p>Pitolisant is an inverse agonist and antagonist of the histamine (H3) receptor. It acts as an allosteric modulator of the H3 receptor to increase the activity of histamine at the M1 receptor. Pitolisant has been used in the treatment of narcolepsy, schizophrenia and Alzheimer's disease. Its mechanism of action involves binding to the amide group on histamine, which increases its affinity for the H3 receptor and enhances its activity at this site. Pitolisant has been shown to improve cognitive ability and reduce fatigue in patients with Alzheimer's disease.</p>Fórmula:C17H26ClNO·HClPureza:Min. 95%Forma y color:White Off-White PowderPeso molecular:332.31 g/molPitolisant hydrochloride - Bio-X ™
CAS:<p>Pitolisant is an inverse agonist and antagonist of the histamine (H3) receptor. It acts as an allosteric modulator of the H3 receptor to increase the activity of histamine at the M1 receptor. Pitolisant has been used in the treatment of narcolepsy, schizophrenia and Alzheimer's disease. Its mechanism of action involves binding to the amide group on histamine, which increases its affinity for the H3 receptor and enhances its activity at this site. Pitolisant has been shown to improve cognitive ability and reduce fatigue in patients with Alzheimer's disease.<br>Pitolisant is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C17H26ClNO·HClPureza:Min. 98 Area-%Forma y color:PowderPeso molecular:332.31 g/mol
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