CAS 90729-43-4
:Ebastina
Descripción:
Ebastina es un antihistamínico de segunda generación que se utiliza principalmente para aliviar síntomas alérgicos como la rinitis y la urticaria. Funciona como un antagonista selectivo del receptor H1 de histamina, lo que ayuda a reducir los efectos de la histamina en el cuerpo, mitigando así las reacciones alérgicas. Ebastina se caracteriza por sus efectos sedantes relativamente bajos en comparación con los antihistamínicos de primera generación, lo que lo hace adecuado para un uso a largo plazo sin somnolencia significativa. La sustancia se administra típicamente por vía oral y es conocida por su rápida absorción y metabolismo, con una vida media que permite una dosificación una vez al día. Químicamente, Ebastina es un derivado de piperidina, y su estructura incluye un grupo fenilo, lo que contribuye a su actividad farmacológica. Generalmente es bien tolerado, con un perfil de efectos secundarios que puede incluir dolor de cabeza, fatiga y boca seca, aunque estos son menos comunes. Ebastina también es notable por su capacidad para cruzar la barrera hematoencefálica en menor medida que los antihistamínicos más antiguos, lo que es un factor clave en sus propiedades sedantes reducidas.
Fórmula:C32H39NO2
InChI:InChI=1/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
Clave InChI:InChIKey=MJJALKDDGIKVBE-UHFFFAOYSA-N
SMILES:C(OC1CCN(CCCC(=O)C2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Sinónimos:- 1-(4-(1,1-Dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-1-butanone
- 1-(4-Tert-Butylphenyl)-4-[4-(Diphenylmethoxy)Piperidin-1-Yl]Butan-1-One
- 1-Butanone, 1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-
- 4'-tert-Butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
- 4-Diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
- Bastel
- Ebastel
- Ebastin
- Ebastina
- Ebastina [Spanish]
- Ebastine [USAN:INN]
- Ebastinum
- Ebastinum [Latin]
- Erostin
- Kestine
- Las W-090
- Rp 64305
- Unii-Tqd7Q784P1
- Ebastine
- EBASTINE, IMPURITY C4-(DIPHENYLMETHOXY)PIPERIDINE EP STANDARD
- 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
- Ebasine
- EBASTINE, IMPURITY D1-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(4-HYDROXYPIPERIDIN-1-YL)BUTAN-1-ONE EP STANDARD
- 1-butanone,1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidiny
- Estivan
- EVASTEL
- EBASTINE, MM STANDARD
- EBASTINE, REFERENCE SPECTRUM EP STANDARD
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Ebastine
CAS:Fórmula:C32H39NO2Pureza:>98.0%(HPLC)(T)Forma y color:White to Almost white powder to crystalPeso molecular:469.671-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone
CAS:Fórmula:C32H39NO2Pureza:98%Forma y color:SolidPeso molecular:469.6576Ebastine (Standard)
CAS:Ebastine (Standard) is the standard substance of Ebastine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i. e not causing sedation or drowsiness.Fórmula:C32H39NO2Peso molecular:469.6576Ebastine
CAS:Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),Fórmula:C32H39NO2Forma y color:NeatPeso molecular:469.66Ebastine
CAS:Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine.Fórmula:C32H39NO2Pureza:99.65% - 99.99%Forma y color:White To Off-White PowderPeso molecular:469.6576Ebastine
CAS:4-(4-(Benzhydryloxy)piperidin-1-yl)-1-(4-(tert-butyl)phenyl)butan-1-oneFórmula:C32H39NO2Pureza:98%Peso molecular:469.66Ebastine
CAS:Ebastine is a H1 receptor antagonist that belongs to the group of antihistamines. Ebastine inhibits histamine release from mast cells and basophils and may also have some anticancer activity. It has been shown to be effective in clinical trials, used to treat rhinitis and allergic symptoms such as itching and watery eyes. Ebastine is also non-sedating is not metabolized by cytochrome P450 enzymes but may affect their activity due to its binding affinity for proteins such as albumin and α1-acid glycoprotein.Fórmula:C32H39NO2Pureza:Min. 95%Forma y color:White PowderPeso molecular:469.66 g/molEbastine - Bio-X ™
CAS:Ebastine is a H1 receptor antagonist that belongs to the group of antihistamines. Ebastine inhibits histamine release from mast cells and basophils and may also have some anticancer activity. It has been shown to be effective in clinical trials, used to treat rhinitis and allergic symptoms such as itching and watery eyes. Ebastine is also non-sedating is not metabolized by cytochrome P450 enzymes but may affect their activity due to its binding affinity for proteins such as albumin and α1-acid glycoprotein.Fórmula:C32H39NO2Pureza:(%) Min. 95%Forma y color:PowderPeso molecular:469.66 g/mol
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