CAS 94535-01-0

Fórmula: C8H10O3

InChI: InChI=1S/C8H10O3/c9-6-1-2-8(10)3-4-11-7(8)5-6/h1-2,7,10H,3-5H2/t7-,8+/m1/s1

Clave InChI: HSGPAWIMHOPPDA-SFYZADRCSA-N

SMILES: C1CO[C@H]2[C@@]1(C=CC(=O)C2)O

Halleridone

CAS: 94535-01-0

Halleridone is a natural compound isolated from the stems of Cornus walteri, recognized for its ability to activate the Nrf2 signaling pathway. It promotes Nrf2 nuclear translocation and upregulates heme oxygenase-1 (HO-1) expression in murine hippocampal HT22 cells. The compound also suppresses Aβ1-42-induced inflammatory mediators, including IL-1β, IL-6, prostaglandin E2, and nitric oxide, while reducing pNF-κB nuclear accumulation. Researchers utilize halleridone to study antioxidant response element activation and neuroinflammatory signaling in cellular models of neurodegeneration.

Fórmula: C₈H₁₀O₃

Forma y color: Solid

Peso molecular: 154.1632

Ref: TM-T84864