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EGFR

EGFR

Los inhibidores del receptor del factor de crecimiento epidérmico (EGFR) son compuestos que bloquean la señalización del EGFR, un receptor que a menudo está sobreexpresado en varios tipos de cáncer y que juega un papel crucial en la angiogénesis. Los inhibidores del EGFR se utilizan para prevenir el crecimiento tumoral y las metástasis al interrumpir las vías que promueven la formación de vasos sanguíneos en los tumores. Estos inhibidores son ampliamente utilizados en la investigación y terapia contra el cáncer. En CymitQuimica, ofrecemos una amplia selección de inhibidores de EGFR de alta calidad para apoyar su investigación en oncología y angiogénesis.

Se han encontrado 572 productos de "EGFR"

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  • EGFR-IN-74


    <p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>
    Fórmula:C32H28BrF3N6O4S
    Forma y color:Solid
    Peso molecular:729.57
  • MS 154

    CAS:
    <p>MS 154 is a potent PROTAC® targeting mutant EGFR in lung cancer, sparing WT-EGFR; effective in mice, with DC50 of 11-25 nM.</p>
    Fórmula:C46H54ClFN8O8
    Forma y color:Solid
    Peso molecular:901.42
  • EGFR-IN-33

    CAS:
    <p>EGFR-IN-33, a low-toxicity acrylamide, inhibits EGFR, aiding against cancer, especially NSCLC (from WO2021185348A1, comp. 13).</p>
    Fórmula:C26H25ClN6O2
    Forma y color:Solid
    Peso molecular:488.97
  • Nazartinib S-enantiomer

    CAS:
    <p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>
    Fórmula:C26H31ClN6O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:495.02
  • EGFR-IN-1

    CAS:
    <p>EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.</p>
    Fórmula:C28H30N6O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:514.58
  • Simotinib

    CAS:
    <p>Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.</p>
    Fórmula:C25H26ClFN4O4
    Pureza:99.7%
    Forma y color:Solid
    Peso molecular:500.95
  • Sevabertinib

    CAS:
    <p>Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.</p>
    Fórmula:C24H25ClN4O5
    Pureza:99.81%
    Forma y color:Solid
    Peso molecular:484.93
  • EGFR-IN-1 hydrochloride

    CAS:
    <p>EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.</p>
    Fórmula:C28H31ClN6O4
    Pureza:99.16%
    Forma y color:Solid
    Peso molecular:551.04
  • EGFR-IN-87

    CAS:
    <p>EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,</p>
    Fórmula:C28H33N7O2
    Pureza:98.64%
    Forma y color:Solid
    Peso molecular:499.61
  • BGB-8035

    CAS:
    <p>BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.</p>
    Fórmula:C24H31N5O4
    Pureza:96.74%
    Forma y color:Solid
    Peso molecular:453.53
  • EGFR/ErbB-2 inhibitor-1

    CAS:
    <p>EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.</p>
    Fórmula:C23H15ClFN3OS2
    Pureza:98.93%
    Forma y color:Solid
    Peso molecular:467.97
  • EGFR-IN-8

    CAS:
    <p>EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC</p>
    Fórmula:C32H23ClF3N7O4
    Pureza:99.51%
    Forma y color:Solid
    Peso molecular:662.02
  • BML-265

    CAS:
    <p>BML-265 is a potent inhibitor of EGFR tyrosine kinase (EGFR tyrosine kinase). It disrupts Golgi apparatus integrity in human cells and hinders the transport of secretory proteins across various substances. In contrast, BML-265 does not affect the integrity and transport of the Golgi apparatus in rodent cells.</p>
    Fórmula:C18H15N3O2
    Forma y color:Solid
    Peso molecular:305.331
  • EGFR-IN-35

    CAS:
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Fórmula:C25H24ClN7O2
    Forma y color:Solid
    Peso molecular:489.96
  • EGFR/HER2-IN-8


    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Fórmula:C16H16N4O2S
    Forma y color:Solid
    Peso molecular:328.39
  • EG31

    CAS:
    <p>EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.</p>
    Fórmula:C30H13Br2N3O6
    Forma y color:Solid
    Peso molecular:671.25
  • JBJ-09-063

    CAS:
    <p>JBJ-09-063: EGFR inhibitor, IC50s 0.147-0.396 nM for various mutants; hinders EGFR/Akt/ERK1/2 phosphorylation; targets TKI-sensitive/resistant lung cancer.</p>
    Fórmula:C31H29FN4O3S
    Forma y color:Solid
    Peso molecular:556.65
  • HER2-IN-9


    <p>HER2-IN-9, an oral HER2 inhibitor (IC50: 0.03 μM), hinders growth and spread of HER2+ breast cancer.</p>
    Fórmula:C19H14BrF3N2O
    Forma y color:Solid
    Peso molecular:423.23
  • JBJ-02-112-05

    CAS:
    <p>JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].</p>
    Fórmula:C27H20N4O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:464.54
  • EGFR-IN-135


    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Fórmula:C12H14N4OS2
    Forma y color:Solid
    Peso molecular:294.4
  • HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Fórmula:C26H25F2N9O3
    Forma y color:Solid
    Peso molecular:549.53
  • EGFR/HER2-IN-7


    <p>EGFR/HER2-IN-7: Potent, selective dual inhibitor for MCF-7 cancer; IC50: EGFR 0.18μM, HER2 0.146μM, DHFR 0.907μM.</p>
    Fórmula:C19H21N3O2S
    Forma y color:Solid
    Peso molecular:355.45
  • EGFR-IN-48


    <p>EGFR-IN-48: potent EGFR inhibitor, oral, IC50: 0.193-66.7 nM, blocks EGFR mutants &amp; BaF3/PC-9 cell proliferation.</p>
    Forma y color:Solid
  • Sacibertinib

    CAS:
    <p>Sacibertinib inhibits Trk, targeting EGFR-TK (EC50 110 nM) &amp; HER2 (EC50 244 nM), with anticancer properties.</p>
    Fórmula:C32H31ClN6O4
    Forma y color:Solid
    Peso molecular:599.08
  • EGFR-IN-17


    <p>EGFR-IN-17: potent, selective EGFR inhibitor, IC50 of 0.2 nM, overcomes C797S drug resistance.</p>
    Fórmula:C27H31ClN7O3P
    Forma y color:Solid
    Peso molecular:568.01
  • EGFR-IN-38

    CAS:
    <p>EGFR-IN-38: low-toxic acrylamide-derived EGFR inhibitor, targets NSCLC, patented for research on EGFR mutation-related diseases.</p>
    Fórmula:C25H24ClN7O2
    Forma y color:Solid
    Peso molecular:489.96
  • EGFR-IN-126

    CAS:
    <p>EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.</p>
    Fórmula:C28H28BrFN4O3
    Forma y color:Solid
    Peso molecular:567.45
  • EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Fórmula:C16H15N3OS
    Forma y color:Solid
    Peso molecular:297.375
  • EGFR-IN-160

    CAS:
    <p>EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM).</p>
    Fórmula:C15H12N2O4
    Forma y color:Solid
    Peso molecular:284.27
  • EGFR/HER2/DHFR-IN-1


    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Fórmula:C14H11BrN4O2S
    Forma y color:Solid
    Peso molecular:379.23
  • EGFR-IN-18


    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Fórmula:C33H28N6O3S
    Forma y color:Solid
    Peso molecular:588.68
  • EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Fórmula:C21H23N3O5
    Forma y color:Solid
    Peso molecular:397.424
  • EGFR/BRAF-IN-1


    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Fórmula:C26H28ClN3O4
    Forma y color:Solid
    Peso molecular:481.97
  • Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Fórmula:C31H36N8O3
    Forma y color:Solid
    Peso molecular:568.669
  • EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Fórmula:C30H26N8O
    Forma y color:Solid
    Peso molecular:514.58
  • EGFR-IN-58


    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Fórmula:C31H30FN7O
    Forma y color:Solid
    Peso molecular:535.61
  • HER2-IN-7

    CAS:
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Fórmula:C28H26F3N7O3
    Forma y color:Solid
    Peso molecular:565.55
  • Tarloxotinib bromide

    CAS:
    <p>Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.</p>
    Fórmula:C24H24Br2ClN9O3
    Pureza:99.52%
    Forma y color:Solid
    Peso molecular:681.77
  • Neptinib

    CAS:
    <p>Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.</p>
    Fórmula:C22H23ClFN5O2
    Forma y color:Solid
    Peso molecular:443.90
  • HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Fórmula:C20H18N4O3S
    Forma y color:Solid
    Peso molecular:394.447
  • NSC381467

    CAS:
    <p>NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Fórmula:C20H16O7
    Forma y color:Solid
    Peso molecular:368.34
  • EGFR-IN-23

    CAS:
    <p>EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.</p>
    Fórmula:C36H44BrN10O3P
    Forma y color:Solid
    Peso molecular:775.68
  • EGFR/HER2-IN-4


    <p>EGFR/HER2-IN-4: oral, irreversible dual EGFR inhibitor (IC50: 0.6 nM), targets L858R/T790M mutations, potent anti-lung cancer effects in vivo.</p>
    Forma y color:Solid
  • EGFR/HER2-IN-5


    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Forma y color:Solid
  • BPI-15086

    CAS:
    <p>BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.</p>
    Fórmula:C29H33ClN8O4
    Forma y color:Solid
    Peso molecular:593.08
  • ES-072

    CAS:
    <p>ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.</p>
    Fórmula:C25H27F3N8O2
    Forma y color:Solid
    Peso molecular:528.53
  • SST0116CL1

    CAS:
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Fórmula:C22H31ClN4O6
    Forma y color:Solid
    Peso molecular:482.96
  • EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Fórmula:C27H25ClN2O4
    Forma y color:Solid
    Peso molecular:476.951
  • HER2-IN-6

    CAS:
    <p>HER2-IN-6, a potent HER2 inhibitor, may target wild/mutant EGFR and HER2-mediated tumors. (Patent WO2021164697A1, compound 11)</p>
    Fórmula:C26H32N8O3
    Forma y color:Solid
    Peso molecular:504.58
  • HER2-IN-12


    <p>HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.</p>
    Fórmula:C17H18BrN5O2S
    Forma y color:Solid
    Peso molecular:436.33
  • LSD1/EGFR-IN-1

    CAS:
    <p>LSD1/EGFR-IN-1 (compound L-1) is an effective inhibitor of LSD1, EGFRT790M/L858R, and EGFRL858R/T790M/C797S, with IC50 values of 6.24, 2.06, and 5.01 μM, respectively. This compound plays a significant role in cancer research.</p>
    Fórmula:C21H20ClN3O4
    Forma y color:Solid
    Peso molecular:413.854
  • EGFR-IN-24


    <p>EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).</p>
    Fórmula:C30H35FN6O3
    Forma y color:Solid
    Peso molecular:546.64
  • EGFR/VEGFR2-IN-2


    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Fórmula:C24H15FO3
    Forma y color:Solid
    Peso molecular:370.37
  • EGFR-IN-147

    CAS:
    <p>EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.</p>
    Fórmula:C13H13N5O
    Forma y color:Solid
    Peso molecular:255.275
  • Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Fórmula:C31H33Cl2FN4O5S
    Forma y color:Solid
    Peso molecular:663.59
  • EGFR-IN-132

    CAS:
    <p>EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.</p>
    Fórmula:C27H31N7O3
    Forma y color:Solid
    Peso molecular:501.58
  • Tyrphostin 63

    CAS:
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Fórmula:C10H8N2O
    Forma y color:Solid
    Peso molecular:172.183
  • EGFR-IN-133

    CAS:
    <p>EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.</p>
    Fórmula:C27H29F2N7O3
    Forma y color:Solid
    Peso molecular:537.56
  • EGFR-IN-34


    <p>EGFR-IN-34 is a low-toxicity, acrylamide derivative antitumor agent that is a potent inhibitor of EGFR.</p>
    Fórmula:C26H27ClN6O2
    Forma y color:Solid
    Peso molecular:490.98
  • Pred17


    <p>Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.</p>
    Fórmula:C27H22BN3O
    Forma y color:Solid
    Peso molecular:415.29
  • NS-062

    CAS:
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Fórmula:C28H30Cl2F2N6O4
    Forma y color:Solid
    Peso molecular:623.48
  • D-69491 hydrochloride

    CAS:
    <p>D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.</p>
    Fórmula:C25H26Cl2FN7O3
    Forma y color:Solid
    Peso molecular:562.42
  • EGFR-IN-130


    <p>EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.</p>
    Fórmula:C27H25N3O6S
    Forma y color:Solid
    Peso molecular:519.57
  • EGFR-IN-7

    CAS:
    <p>EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.</p>
    Fórmula:C32H41BrN9O2P
    Pureza:95.32% - 99.64%
    Forma y color:Solid
    Peso molecular:694.6

    Ref: TM-T11161

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  • Nimotuzumab (powder)

    CAS:
    <p>Nimotuzumab (powder) is a humanized IgG1 monoclonal antibody that specifically targets the epidermal growth factor receptor (EGFR), possessing a dissociation constant (KD) of 0.21 nM. It blocks the binding to its ligand by targeting the extracellular domain of EGFR. Nimotuzumab exhibits strong antitumor activity by inducing both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), exerting cytolytic effects on target tumors.</p>
    Forma y color:Liquid

    Ref: TM-T9901A-1025

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  • HMBD-001


    <p>HMBD-001 is a humanized IgG1 monoclonal antibody inhibitor that targets HER3. By inhibiting the dimerization of HER3, HMBD-001 suppresses the growth and proliferation of tumor cells. It holds potential for research in cancer treatments, specifically for pancreatic cancer and non-small cell lung cancer.</p>
    Forma y color:Odour Liquid

    Ref: TM-T9901A-949

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  • TLC9995-0188

    CAS:
    <p>Tyrosine-protein kinase ABL, IC50: 1500 nM</p>
    Fórmula:C16H15N5
    Forma y color:Yellow Solid
    Peso molecular:277.331

    Ref: TM-T116837

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  • Duligotuzumab

    CAS:
    <p>Duligotuzumab (MEHD-7945A) is a bispecific humanised IgG-κ monoclonal antibody targeting HER3 and EGFR, solid tumours, head and neck cancer,colorectal cancer.</p>
    Pureza:95%
    Forma y color:Liquid

    Ref: TM-T80604

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  • EGFR-IN-82

    CAS:
    <p>EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/</p>
    Fórmula:C32H41BrN9O2P
    Pureza:98%
    Forma y color:Solid
    Peso molecular:694.6

    Ref: TM-T78788

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  • YK-029A

    CAS:
    <p>YK-029A, an orally active EGFR mutant inhibitor, targets both EGFR T790M and EGFRex20ins mutations.</p>
    Fórmula:C27H32N8O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:500.6

    Ref: TM-T79461

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  • EGFR-IN-122

    CAS:
    <p>EGFR-IN-122 (compound Yfq07) serves as a potent inhibitor of EGFR. It effectively inhibits the proliferation of PC-9GR and HCC827GR cells.</p>
    Fórmula:C19H20N4O3
    Forma y color:Solid
    Peso molecular:352.39

    Ref: TM-T200157

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  • EGFR-IN-123

    CAS:
    <p>EGFR-IN-123 (compound D06) is an effective EGFR inhibitor. It exhibits inhibitory activity against several cell lines including PC-9G, A549, A431, and HCT116, with IC50 values of 0.74, 1.36, 1.20, and 2.53 μM respectively.</p>
    Fórmula:C24H27F3N6O
    Forma y color:Solid
    Peso molecular:472.51

    Ref: TM-T200485

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    Descatalogado
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