EGFR
Los inhibidores del receptor del factor de crecimiento epidérmico (EGFR) son compuestos que bloquean la señalización del EGFR, un receptor que a menudo está sobreexpresado en varios tipos de cáncer y que juega un papel crucial en la angiogénesis. Los inhibidores del EGFR se utilizan para prevenir el crecimiento tumoral y las metástasis al interrumpir las vías que promueven la formación de vasos sanguíneos en los tumores. Estos inhibidores son ampliamente utilizados en la investigación y terapia contra el cáncer. En CymitQuimica, ofrecemos una amplia selección de inhibidores de EGFR de alta calidad para apoyar su investigación en oncología y angiogénesis.
Se han encontrado 582 productos de "EGFR"
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JBJ-04-125-02
CAS:JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Fórmula:C29H26FN5O3SPureza:98%Forma y color:SolidPeso molecular:543.61BKI-1369
CAS:BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Fórmula:C23H27N7OForma y color:SolidPeso molecular:417.51EGFR-IN-64
CAS:EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.Fórmula:C20H21N3O3Forma y color:SolidPeso molecular:351.4JNJ28871063 hydrochloride
CAS:ErbB receptor family inhibitorFórmula:C24H28Cl2N6O3Pureza:98%Forma y color:SolidPeso molecular:519.42GW 583340 dihydrochloride
CAS:GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Fórmula:C28H27Cl3FN5O3S2Pureza:98.80%Forma y color:SolidPeso molecular:671.03EGFR/HER2-IN-9
CAS:EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFRFórmula:C25H25ClFN5O4Forma y color:SolidPeso molecular:513.95Mutated EGFR-IN-3
CAS:Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Fórmula:C31H29FN4O2Pureza:98%Forma y color:SolidPeso molecular:508.59Tyrphostin 51
CAS:Tyrphostin 51 is an effective inhibitor of EGFR kinase.Fórmula:C13H8N4O3Pureza:98%Forma y color:SolidPeso molecular:268.23Selatinib
CAS:Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.Fórmula:C29H26ClFN4O3SPureza:98.00%Forma y color:SolidPeso molecular:565.06Mutated EGFR-IN-2
CAS:Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Fórmula:C29H35FN8O3Pureza:98%Forma y color:SolidPeso molecular:562.64MTX-531
CAS:MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.Fórmula:C22H20ClN5O2SForma y color:SoildPeso molecular:453.94EGA
CAS:EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.Fórmula:C16H16BrN3OPureza:98% - 99.6%Forma y color:SolidPeso molecular:346.22DS21360717
CAS:DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Fórmula:C21H23N7OPureza:98%Forma y color:SolidPeso molecular:389.45EGFR-IN-5
CAS:EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.
Fórmula:C31H38FN9OPureza:98.17%Forma y color:SolidPeso molecular:571.69EGFR mutant-IN-2
CAS:EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].Fórmula:C27H27F3N6O2SForma y color:SolidPeso molecular:556.6MS 154N
CAS:MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.Fórmula:C47H56ClFN8O8Forma y color:SolidPeso molecular:915.45HKI-357 dimaleate
CAS:HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Fórmula:C39H37ClFN5O11Forma y color:SolidPeso molecular:806.2EGFR/C797S-IN-1
CAS:EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.Fórmula:C28H30N4O3Forma y color:SolidPeso molecular:470.56Limertinib
CAS:Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Fórmula:C29H32ClN7O2Pureza:97.44%Forma y color:SolidPeso molecular:546.06Ref: TM-T35897
1mg60,00€5mg130,00€10mg187,00€25mg341,00€50mg512,00€100mg770,00€200mg1.035,00€1mL*10mM (DMSO)156,00€EMI48
CAS:EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].Fórmula:C21H20N2O3Forma y color:SolidPeso molecular:348.4EGFR-IN-63
CAS:EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).Fórmula:C20H12BrN5SForma y color:SolidPeso molecular:434.31EphB1-IN-1
CAS:EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Fórmula:C16H12Cl2N4O2Forma y color:SolidPeso molecular:363.2SPH5030
CAS:SPH5030 is an irreversible, selective inhibitor of HER2.Fórmula:C31H31FN8O3Forma y color:SolidPeso molecular:582.63EGFR/HER2-IN-12
CAS:EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Fórmula:C25H17ClN4O3SForma y color:SolidPeso molecular:488.95(E/Z)-AG490
CAS:(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.Fórmula:C17H14N2O3Forma y color:SolidPeso molecular:294.3EGFR-IN-75
EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.Fórmula:C10H6N6S2Forma y color:SolidPeso molecular:274.32EGFR-IN-53
CAS:EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Fórmula:C14H13N3O2SForma y color:SolidPeso molecular:287.34EGFR-IN-28
CAS:EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .Fórmula:C31H39BrN10O3SForma y color:SolidPeso molecular:711.68BAY 2476568
CAS:BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Fórmula:C24H27FN4O4Forma y color:SolidPeso molecular:454.49LDC0496
CAS:LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Fórmula:C32H35N5O3Forma y color:SolidPeso molecular:537.65EGFR-IN-67
CAS:EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Fórmula:C18H17N3SForma y color:SolidPeso molecular:307.41Lavendustin C6
CAS:Lavendustin C6 is a effective tyrosine kinase inhibitor.Fórmula:C20H25NO5Forma y color:SolidPeso molecular:359.42PDZ1i
CAS:PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.Fórmula:C28H26N8O4Forma y color:SolidPeso molecular:538.56Nazartinib mesylate
CAS:Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).Fórmula:C27H35ClN6O5SPureza:98%Forma y color:SolidPeso molecular:591.12PF-06672131
CAS:PF-06672131 is a selective EGFR kinase inhibitor.Fórmula:C23H21ClFN5O2Forma y color:SolidPeso molecular:453.9MJ04
CAS:MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).Fórmula:C20H16FN5Forma y color:SolidPeso molecular:345.37EGFR-IN-73
CAS:EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Fórmula:C19H17ClFN3O4Pureza:98%Forma y color:SolidPeso molecular:405.81Antiproliferative agent-34
CAS:Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Fórmula:C27H27N7O5Pureza:98%Forma y color:SolidPeso molecular:529.55EGFR-IN-89
CAS:EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFórmula:C26H31FN8O2SPureza:98%Forma y color:SolidPeso molecular:538.64NSC81111
CAS:NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].Fórmula:C19H16O4Forma y color:SolidPeso molecular:308.33EGFR-IN-50
CAS:EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.Fórmula:C24H26BrN3O4S2Forma y color:SolidPeso molecular:564.51EGFR-IN-16
CAS:EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
Fórmula:C16H11NO3Pureza:98%Forma y color:SolidPeso molecular:265.26EMI56
CAS:EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].Fórmula:C21H20N2O3Forma y color:SolidPeso molecular:348.4Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Fórmula:C13H8N4OPureza:99.14%Forma y color:SolidPeso molecular:236.23RG 14921
CAS:RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.Fórmula:C11H9NO3Forma y color:SolidPeso molecular:203.19EGFR-IN-49
CAS:EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.Fórmula:C22H15N5O2SForma y color:SolidPeso molecular:413.45NSC114126
CAS:NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.Fórmula:C22H20O4Forma y color:SolidPeso molecular:348.39AFN941
CAS:AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.Fórmula:C28H30N4O3Forma y color:SolidPeso molecular:470.56EGFR-IN-25
CAS:EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Fórmula:C34H43N9O2Forma y color:SolidPeso molecular:609.76JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Fórmula:C31H30ClFN4O3SForma y color:SolidPeso molecular:593.11EAI001
CAS:EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Fórmula:C19H15N3O2SPureza:99.94%Forma y color:SolidPeso molecular:349.41(E/Z)-CP-724714
CAS:(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Fórmula:C27H27N5O3Pureza:98%Forma y color:SolidPeso molecular:469.54MS 39
CAS:MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.Fórmula:C55H71ClFN9O7SForma y color:SolidPeso molecular:1056.72DBPR112
CAS:DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Fórmula:C32H31N5O3Pureza:99.25%Forma y color:SolidPeso molecular:533.62Gefitinib N-oxide
CAS:Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Fórmula:C22H24ClFN4O4Pureza:98%Forma y color:SolidPeso molecular:462.9PF-6422899
CAS:PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR.Fórmula:C20H14ClFN4O2Forma y color:SolidPeso molecular:396.8PD 173955-Analog1
CAS:PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.Fórmula:C21H14Cl2N4O3Forma y color:SolidPeso molecular:441.27Epertinib
CAS:Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Fórmula:C30H27ClFN5O3Pureza:98%Forma y color:SolidPeso molecular:560.02RTC-5
CAS:RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Fórmula:C24H22ClF3N2O3SPureza:98.14%Forma y color:SolidPeso molecular:510.96Ref: TM-T12777
2mg35,00€5mg52,00€10mg78,00€25mg149,00€50mg235,00€100mg376,00€200mg550,00€1mL*10mM (DMSO)55,00€EGFR/HER2-IN-2
CAS:EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Fórmula:C26H23N5O3Forma y color:SolidPeso molecular:453.49UNC-CA359
CAS:UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Fórmula:C18H14ClN3O2Forma y color:SolidPeso molecular:339.78CAY10717
CAS:CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Fórmula:C29H25F3N6O3Forma y color:SolidPeso molecular:562.54SDZ281-977
CAS:SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Fórmula:C18H20O5Pureza:99.64%Forma y color:SolidPeso molecular:316.35EGFR-IN-55
CAS:"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."Fórmula:C25H25Cl2N7O2Forma y color:SolidPeso molecular:526.42BPIQ-II (hydrochloride)
CAS:BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.Fórmula:C15H11BrClN5Forma y color:SolidPeso molecular:376.64Z118332870
CAS:Z118332870 is a potent inhibitor of EGFR and BRD4.Fórmula:C18H18FN3O3Forma y color:SolidPeso molecular:343.35EGFR-IN-2
CAS:EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Fórmula:C26H33N9O3SPureza:98.52% - 99.79%Forma y color:SolidPeso molecular:551.66EGFR-IN-31
CAS:EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)Fórmula:C32H36FN7O2Forma y color:SolidPeso molecular:569.67EGFR-IN-39
CAS:EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.Fórmula:C24H25ClN6O3Forma y color:SolidPeso molecular:480.95Nimotuzumab
CAS:Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).Pureza:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Forma y color:LiquidPeso molecular:147.64 kDaA-935142
CAS:A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Fórmula:C18H19F3N2O2Pureza:98.97% - 99.91%Forma y color:SolidPeso molecular:352.35EGFR-IN-99
CAS:EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Fórmula:C25H22FN7O3Pureza:97.75%Forma y color:SolidPeso molecular:487.49Cloperastine fendizoate
CAS:Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Fórmula:C40H38ClNO5Pureza:99.97%Forma y color:SolidPeso molecular:648.19EMI1
CAS:EMI1 targets mutated EGFR in drug-resistant NSCLC research.Fórmula:C20H18N2O3Pureza:99.96%Forma y color:SolidPeso molecular:334.37PKI-166
CAS:PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.Fórmula:C20H18N4OPureza:99.2%Forma y color:SolidPeso molecular:330.38Ref: TM-T16549
2mg39,00€5mg75,00€10mg111,00€25mg215,00€50mg358,00€100mg572,00€200mg767,00€1mL*10mM (DMSO)84,00€LY 456236 hydrochloride
CAS:LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Fórmula:C16H16ClN3O2Pureza:99.95%Forma y color:SolidPeso molecular:317.77Tyrphostin A25
CAS:Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Fórmula:C10H6N2O3Pureza:98.98%Forma y color:Yellow Green Powder /Off-White SolidPeso molecular:202.17Falnidamol
CAS:Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Fórmula:C18H19ClFN7Pureza:98.816%Forma y color:SolidPeso molecular:387.84Ref: TM-TQ0271
2mg39,00€5mg60,00€10mg96,00€25mg182,00€50mg318,00€100mg439,00€200mg612,00€1mL*10mM (DMSO)60,00€EGFR-IN-9
CAS:EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Fórmula:C29H24N4O3Pureza:99.8%Forma y color:SolidPeso molecular:476.53PD 174265
CAS:PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Fórmula:C17H15BrN4OPureza:99.51%Forma y color:SolidPeso molecular:371.23Rezivertinib
CAS:Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Fórmula:C27H30N6O3Pureza:99.26% - 99.98%Forma y color:SolidPeso molecular:486.57Ref: TM-T36644
1mg60,00€5mg130,00€10mg177,00€25mg326,00€50mg467,00€100mg670,00€200mg888,00€1mL*10mM (DMSO)42,00€Epitinib succinate
CAS:Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Fórmula:C28H32N6O6Pureza:98.02% - 99.79%Forma y color:SolidPeso molecular:548.59Ref: TM-T35914
1mg72,00€2mg92,00€5mg161,00€10mg258,00€25mg425,00€50mg583,00€100mg800,00€500mg1.603,00€EGFR-IN-1
CAS:EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.
Fórmula:C28H30N6O4Pureza:98%Forma y color:SolidPeso molecular:514.58EGFR-IN-29
CAS:EGFR-IN-29 is a potent EGFR inhibitor.Fórmula:C36H46BrN8O2PForma y color:SolidPeso molecular:733.68EGFR mutant-IN-1
EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.Fórmula:C34H39ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:632.17EGFR/CSC-IN-1
CAS:EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potentialFórmula:C54H54Cl2FN7O7S2Pureza:98%Forma y color:SolidPeso molecular:1067.08EGFR-IN-33
CAS:EGFR-IN-33, a low-toxicity acrylamide, inhibits EGFR, aiding against cancer, especially NSCLC (from WO2021185348A1, comp. 13).Fórmula:C26H25ClN6O2Forma y color:SolidPeso molecular:488.97BGB-102
CAS:BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.Fórmula:C22H25BrN4O2Pureza:99.02%Forma y color:SolidPeso molecular:457.36Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFórmula:C25H17F3N4O3Pureza:97.99% - 98%Forma y color:SolidPeso molecular:478.42Ref: TM-T22272
1mg34,00€5mg65,00€10mg92,00€25mg180,00€50mgA consultar100mgA consultar1mL*10mM (DMSO)94,00€2′-Thioadenosine
CAS:2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM againstFórmula:C10H13N5O3SPureza:98%Forma y color:SolidPeso molecular:283.31DZD1516
CAS:DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in bothFórmula:C28H27F2N7O3Pureza:98%Forma y color:SolidPeso molecular:547.56JGK-068S
CAS:Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].Fórmula:C22H23BrFN5O2Pureza:98%Forma y color:SolidPeso molecular:488.35EGFR-IN-61
CAS:EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Fórmula:C33H37ClN8O3Pureza:98%Forma y color:SolidPeso molecular:629.15EGFR-IN-85
CAS:EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFRFórmula:C26H30N8O2Pureza:98%Forma y color:SolidPeso molecular:486.57EGFR-IN-36
CAS:EGFR-IN-36 inhibits EGFR, HER2, & mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).Fórmula:C26H25ClN6O2Forma y color:SolidPeso molecular:488.97(Z)-RG-13022
CAS:(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].Fórmula:C16H14N2O2Forma y color:SolidPeso molecular:266.29BPIQ-I
CAS:BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.Fórmula:C16H12BrN5Forma y color:SolidPeso molecular:354.2EGFR/HER2-IN-11
CAS:EGFR/HER2-IN-11 (compound 20), an orally active dual inhibitor targeting human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), demonstrates IC50 values of 7.7 nM and 22 nM, respectively. This compound shows strong antitumor efficacy, specifically inhibiting the proliferation of BT-474 cancer cells with a GI50 of 601 nM [1].Fórmula:C23H21ClF3N5O2Forma y color:SolidPeso molecular:491.89EGFR-IN-30
CAS:EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, <1 nM WT/mutants) with potential in cancer research.Fórmula:C28H33BrN7O2PForma y color:SolidPeso molecular:610.49PAT-505
CAS:PAT-505 is an autologous epidermal growth factor inhibitor.Fórmula:C23H18ClF2N3O2SPureza:98.84%Forma y color:SolidPeso molecular:473.92
