EGFR
Los inhibidores del receptor del factor de crecimiento epidérmico (EGFR) son compuestos que bloquean la señalización del EGFR, un receptor que a menudo está sobreexpresado en varios tipos de cáncer y que juega un papel crucial en la angiogénesis. Los inhibidores del EGFR se utilizan para prevenir el crecimiento tumoral y las metástasis al interrumpir las vías que promueven la formación de vasos sanguíneos en los tumores. Estos inhibidores son ampliamente utilizados en la investigación y terapia contra el cáncer. En CymitQuimica, ofrecemos una amplia selección de inhibidores de EGFR de alta calidad para apoyar su investigación en oncología y angiogénesis.
Se han encontrado 581 productos de "EGFR"
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Mutated EGFR-IN-2
CAS:Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Fórmula:C29H35FN8O3Pureza:98%Forma y color:SolidPeso molecular:562.64EGA
CAS:EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.Fórmula:C16H16BrN3OPureza:98% - 99.6%Forma y color:SolidPeso molecular:346.22DS21360717
CAS:DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Fórmula:C21H23N7OPureza:98%Forma y color:SolidPeso molecular:389.45EGFR-IN-5
CAS:EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.
Fórmula:C31H38FN9OPureza:98.17%Forma y color:SolidPeso molecular:571.69EGFR mutant-IN-2
CAS:EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].Fórmula:C27H27F3N6O2SForma y color:SolidPeso molecular:556.6MS 154N
CAS:MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.Fórmula:C47H56ClFN8O8Forma y color:SolidPeso molecular:915.45Limertinib
CAS:Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Fórmula:C29H32ClN7O2Pureza:97.44%Forma y color:SolidPeso molecular:546.06Ref: TM-T35897
1mg60,00€5mg130,00€10mg187,00€25mg341,00€50mg512,00€100mg770,00€200mg1.035,00€1mL*10mM (DMSO)156,00€EphB1-IN-1
CAS:EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Fórmula:C16H12Cl2N4O2Forma y color:SolidPeso molecular:363.2EGFR/HER2-IN-12
CAS:EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Fórmula:C25H17ClN4O3SForma y color:SolidPeso molecular:488.95SPH5030
CAS:SPH5030 is an irreversible, selective inhibitor of HER2.Fórmula:C31H31FN8O3Forma y color:SolidPeso molecular:582.63EMI48
CAS:EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].Fórmula:C21H20N2O3Forma y color:SolidPeso molecular:348.4MTX-531
CAS:MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.Fórmula:C22H20ClN5O2SForma y color:SoildPeso molecular:453.94EGFR-IN-39
CAS:EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.Fórmula:C24H25ClN6O3Forma y color:SolidPeso molecular:480.95Z118332870
CAS:Z118332870 is a potent inhibitor of EGFR and BRD4.Fórmula:C18H18FN3O3Forma y color:SolidPeso molecular:343.35BPIQ-II (hydrochloride)
CAS:BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.Fórmula:C15H11BrClN5Forma y color:SolidPeso molecular:376.64PF-6422899
CAS:PF-6422899 irreversibly inhibits EGFR kinase activity by binding covalently to active-site cysteine residues in the ATP binding pocket of EGFR.Fórmula:C20H14ClFN4O2Forma y color:SolidPeso molecular:396.8MJ04
CAS:MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).Fórmula:C20H16FN5Forma y color:SolidPeso molecular:345.37PF-06672131
CAS:PF-06672131 is a selective EGFR kinase inhibitor.Fórmula:C23H21ClFN5O2Forma y color:SolidPeso molecular:453.9EMI56
CAS:EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].Fórmula:C21H20N2O3Forma y color:SolidPeso molecular:348.4Falnidamol
CAS:Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Fórmula:C18H19ClFN7Pureza:98.816%Forma y color:SolidPeso molecular:387.84Ref: TM-TQ0271
2mg39,00€5mg60,00€10mg96,00€25mg182,00€50mg318,00€100mg439,00€200mg612,00€1mL*10mM (DMSO)60,00€EGFR-IN-99
CAS:EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor for the study of non-small cell lung cancer (NSCLC).Fórmula:C25H22FN7O3Pureza:97.75%Forma y color:SolidPeso molecular:487.49LY 456236 hydrochloride
CAS:LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Fórmula:C16H16ClN3O2Pureza:99.95%Forma y color:SolidPeso molecular:317.77Cloperastine fendizoate
CAS:Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Fórmula:C40H38ClNO5Pureza:99.97%Forma y color:SolidPeso molecular:648.19Tyrphostin A25
CAS:Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Fórmula:C10H6N2O3Pureza:98.98%Forma y color:Yellow Green Powder /Off-White SolidPeso molecular:202.17EMI1
CAS:EMI1 targets mutated EGFR in drug-resistant NSCLC research.Fórmula:C20H18N2O3Pureza:99.96%Forma y color:SolidPeso molecular:334.37PD 174265
CAS:PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Fórmula:C17H15BrN4OPureza:99.51%Forma y color:SolidPeso molecular:371.23A-935142
CAS:A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Fórmula:C18H19F3N2O2Pureza:98.97% - 99.91%Forma y color:SolidPeso molecular:352.35Epitinib succinate
CAS:Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Fórmula:C28H32N6O6Pureza:98.02% - 99.79%Forma y color:SolidPeso molecular:548.59Ref: TM-T35914
1mg72,00€2mg92,00€5mg161,00€10mg258,00€25mg425,00€50mg583,00€100mg800,00€500mg1.603,00€Rezivertinib
CAS:Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Fórmula:C27H30N6O3Pureza:99.26% - 99.98%Forma y color:SolidPeso molecular:486.57Ref: TM-T36644
1mg60,00€5mg130,00€10mg177,00€25mg326,00€50mg467,00€100mg670,00€200mg888,00€1mL*10mM (DMSO)42,00€EGFR-IN-9
CAS:EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Fórmula:C29H24N4O3Pureza:99.8%Forma y color:SolidPeso molecular:476.53PKI-166
CAS:PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.Fórmula:C20H18N4OPureza:99.2%Forma y color:SolidPeso molecular:330.38Ref: TM-T16549
2mg39,00€5mg75,00€10mg111,00€25mg215,00€50mg358,00€100mg572,00€200mg767,00€1mL*10mM (DMSO)84,00€JND3229
CAS:JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.Fórmula:C33H41ClN8O2Pureza:98.75%Forma y color:SolidPeso molecular:617.18EGFR/HER2-IN-11
CAS:EGFR/HER2-IN-11 (compound 20), an orally active dual inhibitor targeting human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), demonstrates IC50 values of 7.7 nM and 22 nM, respectively. This compound shows strong antitumor efficacy, specifically inhibiting the proliferation of BT-474 cancer cells with a GI50 of 601 nM [1].Fórmula:C23H21ClF3N5O2Forma y color:SolidPeso molecular:491.89EGFR-IN-1
CAS:EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.
Fórmula:C28H30N6O4Pureza:98%Forma y color:SolidPeso molecular:514.58EGFR-IN-33
CAS:EGFR-IN-33, a low-toxicity acrylamide, inhibits EGFR, aiding against cancer, especially NSCLC (from WO2021185348A1, comp. 13).Fórmula:C26H25ClN6O2Forma y color:SolidPeso molecular:488.97BGB-102
CAS:BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.Fórmula:C22H25BrN4O2Pureza:99.02%Forma y color:SolidPeso molecular:457.36(Z)-RG-13022
CAS:(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].Fórmula:C16H14N2O2Forma y color:SolidPeso molecular:266.29PAT-505
CAS:PAT-505 is an autologous epidermal growth factor inhibitor.Fórmula:C23H18ClF2N3O2SPureza:98.84%Forma y color:SolidPeso molecular:473.92HKI-357
CAS:HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.Fórmula:C31H29ClFN5O3Pureza:99.91%Forma y color:SolidPeso molecular:574.05Ref: TM-T11569
1mg62,00€2mgA consultar5mg125,00€10mg188,00€25mg373,00€50mg540,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)159,00€BEBT-109
CAS:BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.Fórmula:C27H32N8O3Pureza:97.26%Forma y color:SolidPeso molecular:516.6BPIQ-I
CAS:BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.Fórmula:C16H12BrN5Forma y color:SolidPeso molecular:354.2PF-06459988
CAS:PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.Fórmula:C19H22ClN7O3Pureza:98%Forma y color:SolidPeso molecular:431.88EGFR-IN-71
CAS:EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.Fórmula:C16H9ClIN3Forma y color:SolidPeso molecular:405.62EGFR-IN-29
CAS:EGFR-IN-29 is a potent EGFR inhibitor.Fórmula:C36H46BrN8O2PForma y color:SolidPeso molecular:733.68HER2-IN-5
CAS:HER2-IN-5 is an effective inhibitor of orally active HER-2.Fórmula:C27H33N7O3Forma y color:SolidPeso molecular:503.6Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFórmula:C25H17F3N4O3Pureza:97.99% - 98%Forma y color:SolidPeso molecular:478.42Ref: TM-T22272
1mg34,00€5mg65,00€10mg92,00€25mg180,00€50mgA consultar100mgA consultar1mL*10mM (DMSO)94,00€EGFR-IN-30
CAS:EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, <1 nM WT/mutants) with potential in cancer research.Fórmula:C28H33BrN7O2PForma y color:SolidPeso molecular:610.49Nazartinib S-enantiomer
CAS:Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.Fórmula:C26H31ClN6O2Pureza:98%Forma y color:SolidPeso molecular:495.02EGFR-IN-74
EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.Fórmula:C32H28BrF3N6O4SForma y color:SolidPeso molecular:729.57EGFR/HER2-IN-13
CAS:EGFR/HER2-IN-13 (Compd 38) serves as an inhibitor targeting mutant EGFR/HER2s that show resistance to existing drugs. It is primarily utilized in cancer research.Fórmula:C27H36N8O3Forma y color:SolidPeso molecular:520.63
