EGFR
Los inhibidores del receptor del factor de crecimiento epidérmico (EGFR) son compuestos que bloquean la señalización del EGFR, un receptor que a menudo está sobreexpresado en varios tipos de cáncer y que juega un papel crucial en la angiogénesis. Los inhibidores del EGFR se utilizan para prevenir el crecimiento tumoral y las metástasis al interrumpir las vías que promueven la formación de vasos sanguíneos en los tumores. Estos inhibidores son ampliamente utilizados en la investigación y terapia contra el cáncer. En CymitQuimica, ofrecemos una amplia selección de inhibidores de EGFR de alta calidad para apoyar su investigación en oncología y angiogénesis.
Se han encontrado 572 productos de "EGFR"
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PROTAC EGFR degrader 2
Potent PROTAC EGFR degrader 2; IC50: 4.0 nM, DC50: 36.51 nM; inhibits cell growth; for NTR-responsive synthesis.Fórmula:C58H72ClFN12O8SForma y color:SolidPeso molecular:1151.78HER2-IN-20
HER2-IN-20 (compound 32) is a potent and selective inhibitor of HER2WT and HER2YVMA, with IC50 values of 49 and 42 nM, respectively. It holds potential for research in non-small cell lung cancer (NSCLC).Fórmula:C30H27ClFN7O2Peso molecular:571.18988DS06652923
DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.Forma y color:Odour SolidDepatuxizumab MMAF
Depatuxizumab-MMAF, an antibody-drug conjugate (ADC), comprises an EGFR-targeted antibody linked to McMMAF and is utilized in glioblastoma research.Forma y color:LiquidPeso molecular:148.24 kDaBMS-599626 2HCL(714971-09-2 Free base)
CAS:BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative.Fórmula:C27H29Cl2FN8O3Pureza:99.11%Forma y color:Odour SolidPeso molecular:603.47DP-C-4
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].Forma y color:LiquidMS39N
CAS:MS39N (compound 27) serves as the negative control for MS39, capable of binding to EGFR without causing its degradation.Fórmula:C55H71ClFN9O7SPeso molecular:1056.73Inetetamab
Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.Pureza:96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)Forma y color:Odour LiquidEGFR-IN-148
EGFR-IN-148 (compound 8c) is a potent EGFR inhibitor with an IC50 of 0.161 μM. It induces G1/S phase arrest and significantly enhances apoptosis in HepG2 cells.Fórmula:C17H16N4O4SForma y color:SolidPeso molecular:372.398EGFR T790M/L858R-IN-9
EGFRT790M/L858R-IN-9 (Compound 8) is an inhibitor targeting the EGFR-L858R/T790M mutations. It effectively inhibits the phosphorylation of the EGFR-L858R/T790M mutant kinase, demonstrating an IC50 value of 0.0064 µM. Additionally, EGFRT790M/L858R-IN-9 can suppress the proliferation of non-small cell lung cancer (NSCLC) cells, making it useful for cancer research.Fórmula:C26H27N7O3SForma y color:SolidPeso molecular:517.603EGFR WT/T790M/L858R-IN-1
EGFRWT/T790M/L858R-IN-1 (compound 10d) is a potent inhibitor of EGFR, demonstrating IC50 values of 0.097, 0.280, and 0.051 μM for EGFRWT, EGFRT790M, and EGFRL858R, respectively. This compound can be utilized in cancer research.Fórmula:C26H25Cl3N2O3Peso molecular:518.09308EGFR-IN-116
EGFR-IN-116 (compound 14D) is an antineoplastic agent. It exhibits an IC50 value of 0.103 μM for EGFR, 0.069 μM for VEGFR-2, and 19.74 μM for Topo II.Fórmula:C26H22N6O2SPeso molecular:482.1525PROTAC EGFR degrader 3
CAS:Potent PROTAC EGFR degrader 3; excellent against H1975/HCC827 cells; lysosome-involved mutant degradation.Fórmula:C60H77N13O5SForma y color:SolidPeso molecular:1092.4PROTAC EGFR degrader 10
CAS:PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.Fórmula:C49H65ClN10O7SForma y color:SolidPeso molecular:973.62EGFR kinase inhibitor 3
CAS:EGFR kinase inhibitor 3 (compound 2) serves as a dual-action inhibitor targeting both ATP and allosteric sites of the EGFR kinase, exhibiting potent IC50 values of less than 10 nM for wild-type EGFR, 1.5 nM for the L858R mutation, 0.059 nM for the L858R/T790M mutation, and 0.064 nM for the L858R/T790M/C797S mutation. It is classified as a C-linked inhibitor [1].Fórmula:C31H25N7O3SForma y color:SolidPeso molecular:575.64pp60 (v-SRC) Autophosphorylation Site, Phosphorylated
CAS:pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is a phosphorylated peptide derived from an EGFR substrate.Fórmula:C66H110N23O26PForma y color:SolidPeso molecular:1672.715MS9427 TFA
MS9427 TFA: PROTAC EGFR degrader, Kd 7.1 nM (WT), 4.3 nM (L858R), targets mutant EGFR, inhibits NSCLC cell growth, for cancer research.Fórmula:C50H59ClF4N8O14Forma y color:SolidPeso molecular:1107.5EGFR-IN-95
EGFR-IN-95 is a derivative of 2,4-diaminonicotinamide. It effectively inhibits the activity of EGFRdel19/T790M/C797S and L858R/T790M/C797S.Fórmula:C23H28F2N8O3SPeso molecular:534.19731AZ14240475
AZ14240475 is a potent, selective, brain-penetrant inhibitor of EGFREx20Ins mutants (EGFREx20Ins mutants) with a pIC50 of 7.6, playing a significant role in cancer research.Fórmula:C23H15ClF2N6O2Forma y color:SolidPeso molecular:480.854EGFR-IN-15
CAS:EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications.Fórmula:C24H25BrN6O2Forma y color:SolidPeso molecular:509.408JBJ-09-063 TFA
JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.Fórmula:C33H30F4N4O5SForma y color:SolidPeso molecular:670.67Tephrosin
CAS:Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.Fórmula:C23H22O7Pureza:98%Forma y color:SolidPeso molecular:410.42Oritinib
CAS:Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (
Fórmula:C31H37N7O2Pureza:99.62%Forma y color:SoildPeso molecular:539.67BMS-599626
CAS:BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.Fórmula:C27H27FN8O3Pureza:98.73%Forma y color:SolidPeso molecular:530.55SJF 1521
CAS:SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.Fórmula:C57H61ClFN7O9SPureza:99.20%Forma y color:SolidPeso molecular:1074.65Necitumumab
CAS:Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.Pureza:97.9% (SDS-PAGE); 99.1% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.1% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.81 kDaEGFR-IN-140
EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.Fórmula:C27H37FN8O2Forma y color:SolidPeso molecular:524.633EP26
EP26 is an orally active and potent inhibitor of EGFR and PD-L1, with IC50 values of 48.6 nM and 1.77 µM, respectively. It reduces the protein expression of p-EGFR and induces cell cycle arrest at the G0/G1 phase. EP26 shows potential for glioblastoma research.Fórmula:C42H42ClFN4O5Peso molecular:736.28278Ficerafusp alfa
Ficerafusp alfa is a chimeric antibody of the IgG1κ type that targets EGFR, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Forma y color:Odour LiquidEGFR kinase inhibitor 2
EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting the mutations EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S. This compound shows potential in addressing acquired resistance in the treatment of non-small cell lung cancer.Fórmula:C39H40N6O5Peso molecular:672.30602EGFR-IN-124
EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.Forma y color:Odour SolidPetosemtamab (FUT8-KO)
Petosemtamab (FUT8-KO) is a variant of Petosemtamab with the fucosyltransferase 8 gene (FUT8) knocked out. Petosemtamab is a monoclonal antibody (mAb) targeting EGFR (with a Kd of 0.22 nM) and LGR5 (with a Kd of 0.86 nM). This antibody disrupts EGFR signaling and causes receptor degradation in LGR5+ cancer cells. It is applicable in research on solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).Forma y color:Odour LiquidARRY-380 (analog )
CAS:ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.Fórmula:C29H27N7O4SPureza:99.82%Forma y color:SolidPeso molecular:569.63Ref: TM-T2518
1mg34,00€2mg47,00€5mg71,00€10mg104,00€25mg170,00€50mg253,00€100mgA consultar1mL*10mM (DMSO)92,00€DSPE-PEG5000-GE11
DSPE-PEG5000-GE11 is a PEG compound composed of DSPE and the EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells with EGFR overexpression. DSPE-PEG5000-GE11 is utilized in drug delivery.Forma y color:Odour SolidHDS 029
CAS:HDS 029 has a wide range of applications in life science related research.Fórmula:C17H11ClFN5OForma y color:SolidPeso molecular:355.76Caxmotabart
Caxmotabart is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.Forma y color:Odour LiquidU3-1565
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.Pureza:>95.0% (SDS-PAGE); 99.6% (SEC-HPLC) - >95.0% (SDS-PAGE); 99.8% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.82 kDa.EGFR-IN-42
EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.Fórmula:C49H53ClFN5O5Forma y color:SolidPeso molecular:846.43Ontuxizumab
CAS:Ontuxizumab (MORAb-004) is a monoclonal antibody targeting endomelanic acid with anti-tumor effects.Ontuxizumab is a potent IgG1/κ anti-endothelin (TEM-1 orPureza:97.91% (SDS-PAGE); 99.85% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:145 kDaVarlitinib
CAS:Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.Fórmula:C22H19ClN6O2SPureza:99.7%Forma y color:SolidPeso molecular:466.94Istiratumab
CAS:Istiratumab (M-6495) is a bispecific antibody against IGF-1R/ErbB3 for cancer research, promoting receptor degradation.Forma y color:LiquidVislarafusp alfa
Vislarafusp alfa is a humanized IgG1κ antibody that targets EGFR/CD47, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Forma y color:Odour LiquidDacomitinib metabolite M2
CAS:Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M.Fórmula:C27H32ClFN6O4SForma y color:SolidPeso molecular:591.1EGFR-IN-110
EGFR-IN-110 (Compound 6) is a covalent inhibitor of EGFR, demonstrating pIC50 values of 9.2 for the EGFR enzyme and 8.7 for EGFR cells. It exhibits strong efficacy in targeting EGFR and maintains good kinase selectivity.Fórmula:C22H16ClFN4O2Peso molecular:422.09458Varlitinib Tosylate
CAS:Varlitinib Tosylate is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2).Fórmula:C36H35ClN6O8S3Pureza:98%Forma y color:SolidPeso molecular:811.34AMX-818
AMX-818 is a conditionally activated, masked T cell engager (TCE) that targets HER2. It demonstrates potent T cell cytotoxicity against HER2-positive tumor cell lines and can induce tumor regression in vivo. AMX-818 holds promise for research into HER2-positive solid tumors.Forma y color:Odour LiquidOligopeptide-41
Oligopeptide-41 is a bioactive peptide known for its hair growth-promoting effects and is reported to be used as an ingredient in cosmetics [1].Fórmula:C63H90N18O19SPureza:98%Forma y color:SolidPeso molecular:1435.56Pertuzumab
CAS:Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2Pureza:98.00%Forma y color:LiquidPeso molecular:145.44 kDaEGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Forma y color:Odour SolidMatuzumab
CAS:Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Pureza:95%Forma y color:LiquidPeso molecular:145.9 kDa
