EGFR
Los inhibidores del receptor del factor de crecimiento epidérmico (EGFR) son compuestos que bloquean la señalización del EGFR, un receptor que a menudo está sobreexpresado en varios tipos de cáncer y que juega un papel crucial en la angiogénesis. Los inhibidores del EGFR se utilizan para prevenir el crecimiento tumoral y las metástasis al interrumpir las vías que promueven la formación de vasos sanguíneos en los tumores. Estos inhibidores son ampliamente utilizados en la investigación y terapia contra el cáncer. En CymitQuimica, ofrecemos una amplia selección de inhibidores de EGFR de alta calidad para apoyar su investigación en oncología y angiogénesis.
Se han encontrado 581 productos de "EGFR"
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CZC-8004
CAS:CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.
Fórmula:C17H16FN5Pureza:99.29%Forma y color:SolidPeso molecular:309.34CNX-2006
CAS:CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.Fórmula:C26H27F4N7O2Pureza:98.85% - 99.16%Forma y color:SolidPeso molecular:545.53Sapitinib
CAS:Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib orFórmula:C23H25ClFN5O3Pureza:98.89% - 99.83%Forma y color:SolidPeso molecular:473.93Olmutinib
CAS:Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.Fórmula:C26H26N6O2SPureza:99.14% - 99.63%Forma y color:SolidPeso molecular:486.59Ref: TM-T6918
2mg37,00€5mg54,00€10mg84,00€25mg130,00€50mg170,00€100mg268,00€200mg437,00€1mL*10mM (DMSO)56,00€Cyasterone
CAS:Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promisingFórmula:C29H44O8Pureza:99.32% - 99.70%Forma y color:SolidPeso molecular:520.65Leptomycin B
CAS:Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Fórmula:C33H48O6Pureza:97.10% - 99.04%Forma y color:White Crystalline SolidPeso molecular:540.73Ref: TM-T15735
1mg202,00€2mg341,00€5mg620,00€10mg882,00€25mg1.320,00€50mg1.776,00€100mg2.403,00€1mL*10mM (DMSO)283,00€Genistein
CAS:Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.Fórmula:C15H10O5Pureza:98.22% - 99.64%Forma y color:Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether SolidPeso molecular:270.24Rostafuroxin
CAS:Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.Fórmula:C23H34O4Pureza:98.24% - >99.99%Forma y color:SolidPeso molecular:374.51Almonertinib mesylate
CAS:Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Fórmula:C31H39N7O5SPureza:99.92%Forma y color:SolidPeso molecular:621.75Ref: TM-T9865
1mg52,00€5mg110,00€10mg177,00€25mg301,00€50mg425,00€100mg605,00€200mg797,00€1mL*10mM (DMSO)161,00€(Rac)-JBJ-04-125-02
CAS:(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.Fórmula:C29H26FN5O3SPureza:97.57%Forma y color:SolidPeso molecular:543.61Ref: TM-T8872
1mg100,00€5mg205,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€1mL*10mM (DMSO)249,00€Mobocertinib
CAS:Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agentFórmula:C32H39N7O4Pureza:99.47% - 99.97%Forma y color:SolidPeso molecular:585.7CUDC-101
CAS:CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.Fórmula:C24H26N4O4Pureza:95.76% - 99.17%Forma y color:SolidPeso molecular:434.49Afatinib
CAS:Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.9%Forma y color:Off-White SolidPeso molecular:485.94Ref: TM-T21312
5mg34,00€10mg49,00€25mg81,00€50mg109,00€100mg137,00€200mg168,00€500mg284,00€1mL*10mM (DMSO)50,00€PD153035
CAS:PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,Fórmula:C16H14BrN3O2Pureza:98.47% - 99.29%Forma y color:SolidPeso molecular:360.21Nazartinib
CAS:Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (Fórmula:C26H31ClN6O2Pureza:98.63% - ≥95%Forma y color:Solid PowderPeso molecular:495.02Ref: TM-T3506
1mg37,00€5mg79,00€10mg119,00€25mg187,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)87,00€PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Fórmula:C18H18Cl2N6OPureza:97.39%Forma y color:SolidPeso molecular:405.28Cavutilide
CAS:Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.Fórmula:C22H26FN3O3Pureza:99.82% - 99.85%Forma y color:SolidPeso molecular:399.458Gefitinib hydrochloride
CAS:Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.Fórmula:C22H25Cl2FN4O3Pureza:99.8%Forma y color:SolidPeso molecular:483.36Almonertinib hydrochloride
CAS:Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.Fórmula:C30H36ClN7O2Pureza:98.01% - 98.12%Forma y color:SolidPeso molecular:562.1BMS-690514
CAS:BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.Fórmula:C19H24N6O2Pureza:99.08%Forma y color:SolidPeso molecular:368.43Canertinib dihydrochloride
CAS:Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic andFórmula:C24H27Cl3FN5O3Pureza:99.13% - >99.99%Forma y color:SolidPeso molecular:558.86Naquotinib mesylate
CAS:Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFórmula:C31H46N8O6SPureza:98%Forma y color:SolidPeso molecular:658.81Futuximab
CAS:Futuximab is a chimeric monoclonal antibody targeting EGFR, commonly used in combination with zatuximab to form Sym004.Pureza:95% - 97.5% (SDS-PAGE); 96.3% (SEC-HPLC)Forma y color:LiquidPeso molecular:146.28 kDaSerclutamab
CAS:Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).Pureza:98%Forma y color:LiquidBecotatug
CAS:Becotatug (JMT101) is a humanised monoclonal antibody targeting EGFR, antitumour when combined with Osimertinib for treating EGFR-mutated advanced NSCLC.Pureza:95% - 99.1% (SDS-PAGE); 98.1% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.52 kDaElgemtumab
CAS:Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.Pureza:95%Forma y color:LiquidPeso molecular:144.15 kDaAnbenitamab
CAS:Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.Forma y color:LiquidZalutumumab
CAS:Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).Pureza:95%Forma y color:LiquidPeso molecular:146.63 kDaFidasimtamab
CAS:Fidasimtamab, a recombinant human IgG1 bispecific antibody, targets both HER2 and PD-1, bridging T cells and tumor cells to modulate immune responses.Pureza:95% - 98.0% (SDS-PAGE); 98.3% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.72 kDaPonezumab
CAS:Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.Forma y color:LiquidEGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.Forma y color:Lyophilized PowderPeso molecular:90-120 KDa (reducing condition)Ref: TM-TMPJ-00647
1mg2.535,00€5µg90,00€10µg130,00€20µg193,00€50µg381,00€100µg600,00€200µg947,00€500µg1.765,00€Izalontamab
CAS:Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.Pureza:95%+ - 95.3% (SDS-PAGE); 99.2% (SEC-HPLC)Forma y color:LiquidPeso molecular:197.21 kDaEGFR T790M/L858R-IN-8
CAS:EGFRT790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, specifically targeting the EGFRT790M/L858R mutations with an IC50 of 56.8 μM. This compound does not show significant antiproliferative effects on cancer cell lines A549, A431, and NHI-H1975.Fórmula:C16H11BrN2O3Forma y color:SolidPeso molecular:359.17Imgatuzumab
CAS:Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.
Forma y color:LiquidPeso molecular:145.0 (kDa)Tyrphostin AG 494
CAS:Fórmula:C16H12N2O3Pureza:>98.0%(HPLC)(N)Forma y color:Light yellow to Amber to Dark green powder to crystalPeso molecular:280.28lavendustin A
CAS:lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.Fórmula:C21H19NO6Pureza:98%Forma y color:Off-White SolidPeso molecular:381.38Icotinib
CAS:Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Fórmula:C22H21N3O4Pureza:99.76% - 99.94%Forma y color:SolidPeso molecular:391.42ZM323881 hydrochloride
CAS:ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Fórmula:C22H19ClFN3O2Pureza:99.43%Forma y color:SolidPeso molecular:411.86Ref: TM-T1991
1mg34,00€5mg66,00€10mg96,00€25mg225,00€50mg369,00€100mg550,00€200mg780,00€1mL*10mM (DMSO)69,00€IGF-1R modulator 1
CAS:IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.Fórmula:C22H17N3O4Forma y color:SolidPeso molecular:387.39Icotinib Hydrochloride
CAS:Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Fórmula:C22H22ClN3O4Pureza:99.89%Forma y color:SolidPeso molecular:427.88TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Fórmula:C26H25ClF3N5O3Pureza:99.73%Forma y color:SolidPeso molecular:547.96Ref: TM-T6039
1mg38,00€5mg80,00€10mg120,00€25mg216,00€50mg354,00€100mg512,00€200mg727,00€1mL*10mM (DMSO)96,00€EAI001
CAS:EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Fórmula:C19H15N3O2SPureza:99.94%Forma y color:SolidPeso molecular:349.41RG 14467
CAS:RG 14467 is an antagonist of epidermal growth factor-urogastrone.Fórmula:C14H14N2O3Forma y color:SolidPeso molecular:258.27RG 14921
CAS:RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.Fórmula:C11H9NO3Forma y color:SolidPeso molecular:203.19EGFR-IN-49
CAS:EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.Fórmula:C22H15N5O2SForma y color:SolidPeso molecular:413.45AFN941
CAS:AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.Fórmula:C28H30N4O3Forma y color:SolidPeso molecular:470.56EGFR-IN-31
CAS:EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)Fórmula:C32H36FN7O2Forma y color:SolidPeso molecular:569.67HKI-357 dimaleate
CAS:HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Fórmula:C39H37ClFN5O11Forma y color:SolidPeso molecular:806.2EGFR/HER2-IN-3
CAS:EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.Fórmula:C26H23N5O3Forma y color:SolidPeso molecular:453.49EGFR T790M/L858R-IN-5
CAS:EGFR T790M/L858R-IN-5 (example 52) functions as a potent EGFR T790M/L858R inhibitor, demonstrating a 92.9% inhibition rate at a concentration of 0.05 μM [1].Fórmula:C28H31N9OPeso molecular:509.61
