EGFR
Los inhibidores del receptor del factor de crecimiento epidérmico (EGFR) son compuestos que bloquean la señalización del EGFR, un receptor que a menudo está sobreexpresado en varios tipos de cáncer y que juega un papel crucial en la angiogénesis. Los inhibidores del EGFR se utilizan para prevenir el crecimiento tumoral y las metástasis al interrumpir las vías que promueven la formación de vasos sanguíneos en los tumores. Estos inhibidores son ampliamente utilizados en la investigación y terapia contra el cáncer. En CymitQuimica, ofrecemos una amplia selección de inhibidores de EGFR de alta calidad para apoyar su investigación en oncología y angiogénesis.
Se han encontrado 581 productos de "EGFR"
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EGFR-IN-25
CAS:EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Fórmula:C34H43N9O2Forma y color:SolidPeso molecular:609.76JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Fórmula:C31H30ClFN4O3SForma y color:SolidPeso molecular:593.11(E/Z)-CP-724714
CAS:(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Fórmula:C27H27N5O3Pureza:98%Forma y color:SolidPeso molecular:469.54PD 173955-Analog1
CAS:PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.Fórmula:C21H14Cl2N4O3Forma y color:SolidPeso molecular:441.27EGFR/HER2-IN-2
CAS:EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Fórmula:C26H23N5O3Forma y color:SolidPeso molecular:453.49UNC-CA359
CAS:UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Fórmula:C18H14ClN3O2Forma y color:SolidPeso molecular:339.78CAY10717
CAS:CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Fórmula:C29H25F3N6O3Forma y color:SolidPeso molecular:562.54EGFR/HER2-IN-9
CAS:EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFRFórmula:C25H25ClFN5O4Forma y color:SolidPeso molecular:513.95EGFR/C797S-IN-1
CAS:EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.Fórmula:C28H30N4O3Forma y color:SolidPeso molecular:470.56EGFR-IN-63
CAS:EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).Fórmula:C20H12BrN5SForma y color:SolidPeso molecular:434.31BIBX 1382 Dihydrochloride
CAS:BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.Fórmula:C18H21Cl3FN7Forma y color:SolidPeso molecular:460.76EGFR-IN-69
CAS:EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Fórmula:C31H37Cl2N7O3SForma y color:SolidPeso molecular:658.64EGFR-IN-54
CAS:EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Fórmula:C17H14N4O4S3Forma y color:SolidPeso molecular:434.51EGFR-IN-21
CAS:EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Fórmula:C36H44BrN10O2PForma y color:SolidPeso molecular:759.68Tarlox-TKI
CAS:Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Fórmula:C19H18BrClN6OPureza:97.03%Forma y color:SolidPeso molecular:461.74(E/Z)-AG490
CAS:(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.Fórmula:C17H14N2O3Forma y color:SolidPeso molecular:294.3EGFR-IN-75
EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.Fórmula:C10H6N6S2Forma y color:SolidPeso molecular:274.32EGFR-IN-53
CAS:EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Fórmula:C14H13N3O2SForma y color:SolidPeso molecular:287.34EGFR-IN-28
CAS:EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .Fórmula:C31H39BrN10O3SForma y color:SolidPeso molecular:711.68BAY 2476568
CAS:BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Fórmula:C24H27FN4O4Forma y color:SolidPeso molecular:454.49LDC0496
CAS:LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Fórmula:C32H35N5O3Forma y color:SolidPeso molecular:537.65EGFR-IN-67
CAS:EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Fórmula:C18H17N3SForma y color:SolidPeso molecular:307.41Lavendustin C6
CAS:Lavendustin C6 is a effective tyrosine kinase inhibitor.Fórmula:C20H25NO5Forma y color:SolidPeso molecular:359.42PDZ1i
CAS:PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.Fórmula:C28H26N8O4Forma y color:SolidPeso molecular:538.56Nazartinib mesylate
CAS:Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).Fórmula:C27H35ClN6O5SPureza:98%Forma y color:SolidPeso molecular:591.12EGFR-IN-73
CAS:EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Fórmula:C19H17ClFN3O4Pureza:98%Forma y color:SolidPeso molecular:405.81Antiproliferative agent-34
CAS:Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Fórmula:C27H27N7O5Pureza:98%Forma y color:SolidPeso molecular:529.55EGFR-IN-89
CAS:EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFórmula:C26H31FN8O2SPureza:98%Forma y color:SolidPeso molecular:538.64NSC81111
CAS:NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].Fórmula:C19H16O4Forma y color:SolidPeso molecular:308.33EGFR-IN-50
CAS:EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.Fórmula:C24H26BrN3O4S2Forma y color:SolidPeso molecular:564.51EGFR-IN-16
CAS:EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
Fórmula:C16H11NO3Pureza:98%Forma y color:SolidPeso molecular:265.26Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Fórmula:C13H8N4OPureza:99.14%Forma y color:SolidPeso molecular:236.23NSC114126
CAS:NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.Fórmula:C22H20O4Forma y color:SolidPeso molecular:348.39MS 39
CAS:MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.Fórmula:C55H71ClFN9O7SForma y color:SolidPeso molecular:1056.72DBPR112
CAS:DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Fórmula:C32H31N5O3Pureza:99.25%Forma y color:SolidPeso molecular:533.62Gefitinib N-oxide
CAS:Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Fórmula:C22H24ClFN4O4Pureza:98%Forma y color:SolidPeso molecular:462.9Epertinib
CAS:Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Fórmula:C30H27ClFN5O3Pureza:98%Forma y color:SolidPeso molecular:560.02RTC-5
CAS:RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Fórmula:C24H22ClF3N2O3SPureza:98.14%Forma y color:SolidPeso molecular:510.96Ref: TM-T12777
2mg35,00€5mg52,00€10mg78,00€25mg149,00€50mg235,00€100mg376,00€200mg550,00€1mL*10mM (DMSO)55,00€SDZ281-977
CAS:SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Fórmula:C18H20O5Pureza:99.64%Forma y color:SolidPeso molecular:316.35EGFR-IN-2
CAS:EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Fórmula:C26H33N9O3SPureza:98.52% - 99.79%Forma y color:SolidPeso molecular:551.66Nimotuzumab
CAS:Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).Pureza:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Forma y color:LiquidPeso molecular:147.64 kDaEGFR-IN-68
CAS:EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.Fórmula:C24H22N2OForma y color:SolidPeso molecular:354.44JBJ-04-125-02
CAS:JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Fórmula:C29H26FN5O3SPureza:98%Forma y color:SolidPeso molecular:543.61BKI-1369
CAS:BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Fórmula:C23H27N7OForma y color:SolidPeso molecular:417.51EGFR-IN-64
CAS:EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.Fórmula:C20H21N3O3Forma y color:SolidPeso molecular:351.4JNJ28871063 hydrochloride
CAS:ErbB receptor family inhibitorFórmula:C24H28Cl2N6O3Pureza:98%Forma y color:SolidPeso molecular:519.42GW 583340 dihydrochloride
CAS:GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Fórmula:C28H27Cl3FN5O3S2Pureza:98.80%Forma y color:SolidPeso molecular:671.03Mutated EGFR-IN-3
CAS:Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Fórmula:C31H29FN4O2Pureza:98%Forma y color:SolidPeso molecular:508.59Tyrphostin 51
CAS:Tyrphostin 51 is an effective inhibitor of EGFR kinase.Fórmula:C13H8N4O3Pureza:98%Forma y color:SolidPeso molecular:268.23Selatinib
CAS:Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.Fórmula:C29H26ClFN4O3SPureza:98.00%Forma y color:SolidPeso molecular:565.06
