BTK

ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s …

MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has …

Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

Tirabrutinib hydrochloride is a selective and novelBTK with IC50 2.2 nm inhibitor.

GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical …

IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A …

PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 …

Btk inhibitor 2 is a BTK inhibitor extracted from patent US 20170224688 A1 (BGB-3111 analog).

Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) …

(±)-Zanubrutinib is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior …

Tirabrutinib (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain …

(R)-Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK).

PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.

BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.

Evobrutinib, also known as M-2951 and MSC-2364447C, is a highly selective inhibitor of the Bruton's …

Acalabrutinib enantiomer is a chemical compound that belongs to the class of Bruton’s tyrosine kinase …

BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor …

Vecabrutinib is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 …

Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is …

DZD9008 is a rationally designed selective, irreversible EGFR/HER2 inhibitor.

Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor …

RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).

Tolebrutinib is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of …

Spebrutinib is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential …

Olmutinib is an orally available small molecule, a mutant-selective inhibitor of epidermal growth factor receptor …

Zanubrutinib is an inhibitor of Bruton tyrosine kinase (BTK).

Ibrutinib deacryloylpiperidine is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 …

(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be …

Saracatinib (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, …

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of …

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in …

Ibrutinib is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell …

Fenebrutinib is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other …

ONO-4059 analogue is an analogue of ONO-4059, which is a highly potent and selective oral …

CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor. Pirtobrutinib inhibits diverse BTK …

N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and …

BMS986195 is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all …

Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) …

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor …

BMX-IN-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 …

CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.

TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed …

CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an …

BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd …

BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).

BTK IN-1 (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).

JAK3/BTK-IN-1 is a potent JAK3/BTK inhibitor. BTK and JAK3 are two important targets for autoimmune …

Naluzotan is an effective and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr …

N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with …

JAK3/BTK-IN-2 is a potent JAK3/BTK inhibitor. BTK and JAK3 are two important targets for autoimmune …

ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for …

SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor …

BTK inhibitor 1 (compound 27) is an inhibitor ofBTKwith an IC50 of 0.11 nM for …

PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM. PF-06250112 displays an …

Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, …

G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is …

CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK …