BTK
Los inhibidores de la tirosina quinasa de Bruton (BTK) son compuestos que específicamente se dirigen e inhiben la BTK, una enzima crucial involucrada en la señalización del receptor de células B y en la regulación de la angiogénesis. La BTK desempeña un papel significativo en la proliferación y supervivencia de las células cancerosas, particularmente en las malignidades hematológicas. Al inhibir la BTK, estos compuestos pueden interrumpir la angiogénesis y el crecimiento tumoral, lo que los convierte en valiosos en la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de BTK de alta calidad para apoyar su investigación en oncología, inmunología y angiogénesis.
Se han encontrado 146 productos de "BTK"
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(Z)-LFM-A13
CAS:(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Fórmula:C11H8Br2N2O2Pureza:99.88%Forma y color:SolidPeso molecular:360Fenebrutinib
CAS:<p>Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki: 0.91 nM).</p>Fórmula:C37H44N8O4Pureza:98.26% - 98.94%Forma y color:SolidPeso molecular:664.8Ibrutinib
CAS:<p>Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.</p>Fórmula:C25H24N6O2Pureza:98% - 99.93%Forma y color:SolidPeso molecular:440.5PCI 29732
CAS:<p>PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.</p>Fórmula:C22H21N5OPureza:99.81%Forma y color:SolidPeso molecular:371.43Remibrutinib
CAS:<p>Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood.</p>Fórmula:C27H27F2N5O3Pureza:99.5% - 99.81%Forma y color:SolidPeso molecular:507.53BIIB068
CAS:<p>BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.</p>Fórmula:C23H29N7O2Pureza:97.98%Forma y color:SolidPeso molecular:435.52Ibrutinib deacryloylpiperidine
CAS:<p>Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.</p>Fórmula:C17H13N5OPureza:99.47%Forma y color:SolidPeso molecular:303.32CHMFL-BMX-078
CAS:<p>CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.</p>Fórmula:C33H35N7O6Pureza:>99.99%Forma y color:SolidPeso molecular:625.67N-piperidine Ibrutinib
CAS:<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Fórmula:C22H22N6OPureza:96.65%Forma y color:SolidPeso molecular:386.45zanubrutinib
CAS:<p>Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK).</p>Fórmula:C27H29N5O3Pureza:98.42% - 99.76%Forma y color:SolidPeso molecular:471.55BMS-986142
CAS:<p>BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).</p>Fórmula:C32H30F2N4O4Pureza:98.7% - 99.76%Forma y color:SolidPeso molecular:572.6Acalabrutinib
CAS:<p>Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.</p>Fórmula:C26H23N7O2Pureza:98.94% - 99.64%Forma y color:SolidPeso molecular:465.51(Rac)-IBT6A
CAS:<p>(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.</p>Fórmula:C22H22N6OPureza:99.24%Forma y color:SolidPeso molecular:386.45TL-895
CAS:<p>TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).</p>Fórmula:C25H26FN5O2Pureza:99.96%Forma y color:SolidPeso molecular:447.5Spebrutinib
CAS:<p>Spebrutinib (LMK-435) is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic</p>Fórmula:C22H22FN5O3Pureza:97.02% - >99.99%Forma y color:SolidPeso molecular:423.44ONO-4059 analog
CAS:<p>ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.</p>Fórmula:C25H24N6O3Pureza:99.25%Forma y color:SolidPeso molecular:456.5RN486
CAS:<p>RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).</p>Fórmula:C35H35FN6O3Pureza:99.38%Forma y color:SolidPeso molecular:606.69Branebrutinib
CAS:<p>Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family.</p>Fórmula:C20H23FN4O2Pureza:95.86% - 99.31%Forma y color:SolidPeso molecular:370.42Larotinib mesylate hydrate
CAS:<p>Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nM</p>Fórmula:C26H36ClFN4O11S2Forma y color:SolidPeso molecular:699.17CNX-774
CAS:<p>CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).</p>Fórmula:C26H22FN7O3Pureza:97.35% - 99.11%Forma y color:SolidPeso molecular:499.5CGI-1746
CAS:<p>CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.</p>Fórmula:C34H37N5O4Pureza:97.69% - 97.88%Forma y color:SolidPeso molecular:579.69Avitinib
CAS:<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Fórmula:C26H26FN7O2Pureza:99.81% - >99.99%Forma y color:SolidPeso molecular:487.53BTK IN-1
CAS:<p>BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).</p>Fórmula:C19H21ClN6OPureza:97.38%Forma y color:SolidPeso molecular:384.86BTK Protein, Human, Recombinant (His)
<p>Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.</p>Pureza:90%Forma y color:Lyophilized PowderPeso molecular:78.3 kDa (predicted)Ibrutinib-d5
CAS:<p>Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.</p>Fórmula:C25H24N6O2Pureza:98%Forma y color:SolidPeso molecular:445.53SJF620
CAS:<p>SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).</p>Fórmula:C41H44N8O7Pureza:98%Forma y color:SolidPeso molecular:760.84JAK3/BTK-IN-5
CAS:<p>JAK3/BTK-IN-5 is a potent dual inhibitor targeting JAK3 and BTK with synergistic effects, valuable for related autoimmune disease research.</p>Fórmula:C19H22ClN7O2Forma y color:SolidPeso molecular:415.88JS25
CAS:<p>JS25, a selective BTK inhibitor, inactivates it with a 5.8 nM IC50, halts cancer cell growth, induces death, and aids against lymphoma.</p>Fórmula:C29H24N4O4SForma y color:SolidPeso molecular:524.59BLK-IN-2
CAS:<p>BLK-IN-2为一种高效、选择性且不可逆的B-淋巴酪氨酸激酶(BLK)抑制剂，具有5.9 nM的IC50值。该化合物亦能抑制BTK，其IC50值为202.0 nM。BLK-IN-2在多种淋巴瘤细胞中展现出显著的抗增殖作用。</p>Fórmula:C39H41N9O3Forma y color:SolidPeso molecular:683.8GDC-0834 Racemate
CAS:<p>GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor</p>Fórmula:C33H36N6O3SForma y color:SolidPeso molecular:596.74EGFR-IN-40
CAS:<p>EGFR-IN-40 (compound 3z) is a potent inhibitor of BTK (IC50: 1.2 nM), EGFR (IC50: 5.3 nM) and ITK (IC50: 46.1 nM).</p>Fórmula:C23H20N6O3Forma y color:SolidPeso molecular:428.44BTK inhibitor 10
CAS:<p>BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.</p>Fórmula:C25H23N5O3Pureza:98%Forma y color:SolidPeso molecular:441.48Ibrutinib-MPEA
CAS:<p>Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies.</p>Fórmula:C32H39N9O2Forma y color:SolidPeso molecular:581.71JNJ-64264681
CAS:<p>JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).</p>Fórmula:C27H30N6O3SPureza:98%Forma y color:SolidPeso molecular:518.63(R)-Elsubrutinib
CAS:<p>(R)-Elsubrutinib ((R)-ABBV-105), a Btk inhibitor, is used in research on immune diseases and cancer.</p>Fórmula:C17H19N3O2Forma y color:SolidPeso molecular:297.35DPPY
CAS:<p>DPPY inhibits EGFR, BTK, JAK3 (IC50<10 nM), curbs B-cell lymphoma growth, and may be studied for IPF treatment.</p>Fórmula:C25H26ClN7O3Forma y color:SolidPeso molecular:507.97SB-633825
CAS:<p>SB-633825 can inhibit cancer cell growth and angiogenesis.</p>Fórmula:C28H25N3O3SPureza:98%Forma y color:SolidPeso molecular:483.58Spebrutinib besylate
CAS:<p>Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).</p>Fórmula:C28H28FN5O6SPureza:98%Forma y color:SolidPeso molecular:581.62ACP-5862
CAS:<p>ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.</p>Fórmula:C26H23N7O3Forma y color:SolidPeso molecular:481.51CHMFL-BTK-01
CAS:<p>CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.</p>Fórmula:C38H41N5O5Pureza:98%Forma y color:SolidPeso molecular:647.76JAK3/BTK-IN-6
CAS:<p>JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.</p>Fórmula:C21H17BF3N5O3Forma y color:SolidPeso molecular:455.2BI-1622
CAS:<p>BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.</p>Fórmula:C26H24N10O2Forma y color:SolidPeso molecular:508.53BLK-IN-1
CAS:<p>BLK-IN-1 selectively blocks BLK and BTK with IC50s of 18.8 and 20.5 nM, used in cancer research.</p>Fórmula:C29H23F3N6O3Forma y color:SolidPeso molecular:560.53BTK-IN-23
CAS:<p>BTK-IN-23: BTK inhibitor, IC50=12.8 nM; also blocks BLX (35.6 nM), BMX (5.7 nM); better selectivity than Ibrutinib.</p>Fórmula:C27H28N6O2Forma y color:SolidPeso molecular:468.55PF-06465469
CAS:<p>PF-06465469 is a covalent ITK inhibitor(IC50: 2 nM).</p>Fórmula:C30H33N7O2Pureza:98%Forma y color:SolidPeso molecular:523.63VA5 TG2 inhibitor
CAS:<p>VA5 inhibits transamidase and GTP-binding by locking protein in an open state, disabling GTPase.</p>Fórmula:C31H34N4O8Pureza:98%Forma y color:SolidPeso molecular:590.62BTK-IN-22
CAS:<p>BTK-IN-22 is a selective BTK inhibitor with IC50 of 0.9 nM; also targets BLX, BMX (IC50s: 1.4, 1.2 nM); better selectivity than Ibrutinib.</p>Fórmula:C26H26N6O2Forma y color:SolidPeso molecular:454.52CGI560
CAS:<p>CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK.</p>Fórmula:C29H27N5OForma y color:SolidPeso molecular:461.56HZ-A-005
CAS:<p>HZ-A-005 is a selective, potent, covalent inhibitor of Bruton's tyrosine kinase (BTK). HZ-A-005 significantly inhibits tumour growth in a xenograft mouse model.</p>Fórmula:C25H23ClN6O2Forma y color:SolidPeso molecular:474.94BLK degrader 1
CAS:<p>BLK degrader 1 is a BLK degrader with anticancer activity for cancer research.</p>Fórmula:C32H25F3N6O2Pureza:99.22% - 99.24%Forma y color:SolidPeso molecular:582.58
