Syk

Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata …

Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for …

Gusacitinib (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).

Adrenalone hydrochloride, a selective α1-adrenoceptor agonist, is used as a topical hemostatic and vasoconstrictor and …

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine …

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 …

Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.

Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma …

GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and …

Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = …

R112 is an ATP-competitive inhibitor of Syk kinase.

Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.

Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to …

Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory …

BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).

Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a …

Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as …

RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).

PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach …

PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least …

BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase …

Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN …

TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 …

Cerdulatinib is an novel oral dual Syk/JAK inhibitor.

MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, …

Entospletinib (IC50= 7.7 nM)is a specific Syk inhibitor, which is orally bioavailable.

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor …

R406 is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.

R406 (free base) is a potent Syk inhibitor.

Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging …

SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.

OXSI-2 is an inhibitor of Syk with an EC50 of 313 nM and an IC50 …

Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging …

TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only …