Syk
Los inhibidores de Syk (tirosina quinasa del bazo) son compuestos que se dirigen a Syk, una quinasa involucrada en la señalización de células inmunitarias y la regulación de la angiogénesis. Syk desempeña un papel en las respuestas inflamatorias que pueden contribuir a la angiogénesis tumoral. Inhibir Syk puede reducir la formación de vasos sanguíneos inducida por la inflamación en los tumores, lo que convierte a estos inhibidores en herramientas valiosas en la terapia contra el cáncer y la investigación sobre inflamación. En CymitQuimica, ofrecemos una amplia gama de inhibidores de Syk de alta calidad para apoyar su investigación en inmunología, oncología y angiogénesis.
Se han encontrado 39 productos para "Syk".
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Fostamatinib Disodium
CAS:Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.Fórmula:C23H24FN6Na2O9PPureza:96.13% - 99.09%Forma y color:White SolidPeso molecular:624.4232BAY 61-3606 dihydrochloride
CAS:BAY 61-3606 dihydrochloride (BAY 61-3606) is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).Fórmula:C20H20Cl2N6O3Pureza:99.46%Forma y color:SolidPeso molecular:463.317Entospletinib
CAS:Entospletinib (GS-9973) is a Syk inhibitor (IC50=7.7 nM) with selective, oral activity. High-Quality, Low-Cost!Fórmula:C23H21N7OPureza:98.54% - 99.74%Forma y color:SolidPeso molecular:411.4591R406
CAS:R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.Fórmula:C28H29FN6O8SPureza:97.67% - 98.88%Forma y color:White SolidPeso molecular:628.629R406 free base
CAS:R406 free base (R406 (free base)) is a potent Syk inhibitor.Fórmula:C22H23FN6O5Pureza:97.64% - 99.11%Forma y color:White SolidPeso molecular:470.4536Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Fórmula:C21H22O11Pureza:98.63% - 99.54%Forma y color:SolidPeso molecular:450.3928TAK-659 hydrochloride
CAS:TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM.Fórmula:C17H22ClFN6OPureza:99.28% - 99.82%Forma y color:SolidPeso molecular:380.848PRT-060318
CAS:PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.Fórmula:C18H24N6OPureza:99.98%Forma y color:White SolidPeso molecular:340.4228Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Fórmula:C20H27N7O3SPureza:98.74% - 99.49%Forma y color:SolidPeso molecular:445.538Cerdulatinib hydrochloride
CAS:Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Fórmula:C20H28ClN7O3SPureza:99.85%Forma y color:SolidPeso molecular:482Syk Inhibitor II
CAS:Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).Fórmula:C14H15F3N6OPureza:97.63%Forma y color:SolidPeso molecular:340.3037Lanraplenib monosuccinate
CAS:Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.Fórmula:C27H31N9O5Pureza:98%Forma y color:SolidPeso molecular:561.59OXSI-2
CAS:OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.Fórmula:C18H15N3O3SPureza:98%Forma y color:SolidPeso molecular:353.39RO9021
CAS:RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).Fórmula:C18H25N7OPureza:99.90%Forma y color:SolidPeso molecular:355.4374Syk-IN-3
CAS:Syk-IN-3 is a Syk inhibitor with potential anti-inflammatory and anticancer activity and can be used to study immune dysregulation.Fórmula:C24H28N4O3SPureza:97.29% - 99.64%Forma y color:Yellow SolidPeso molecular:452.57ER-27319
CAS:ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosineFórmula:C20H22N2O5Pureza:98%Forma y color:SolidPeso molecular:370.4(R,S)-MK-8457
CAS:(R,S)-MK-8457 is a stereoisomer of MK-8457 (T202446) . MK8457 is a dual inhibitor of SYK and ZAP70, valuable for rheumatoid arthritis research.Fórmula:C24H25F3N4O3SForma y color:SolidPeso molecular:506.54As48
CAS:As48 is a selective TREM2 agonist with a KD value of 12.48 μM in the TRIC binding assay. It binds near the TREM2 cleavage region, forming a hydrogen bond with Gly68, which reduces conformational flexibility in the 58-102 region and limits protease access to the cleavage site. As48 activates SYK phosphorylation, enhances microglial phagocytosis, and induces downstream calcium signaling pathways in cells expressing TREM2. It inhibits the shedding of the TREM2 ectodomain without affecting the protease activity of ADAM10/17. As48 is used in Alzheimer's disease research.Fórmula:C20H15N3OSPeso molecular:345.42Sovleplenib
CAS:Sovleplenib (HMPL-523), oral SYK inhibitor, IC50 25 nM, targets tumors & ITP studies.Fórmula:C24H30N6O3SPureza:99.71%Forma y color:SolidPeso molecular:482.6
