FAK

Chloropyramine hydrochloride is a histamine receptor H1 antagonist.

ALK inhibitor 1 is a selective ALK kinase inhibitor.

ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.

WAY-311677 has potential antiproliferative activity and is a FAK inhibitor.

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can …

YH-306 is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor …

5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may …

Defactinib hydrochloride is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 …

PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).

AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.

Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT …

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in …

PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is …

1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast …

Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, …

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 …

PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 …

Defactinib is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and …

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 …

Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid …

Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and …

CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular …

GSK-2256098 is a small molecule FAK kinase inhibitor.

PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).

Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks …

PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).

Masitinib mesylate is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 …

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for …

SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, …

Fangchinoline is extracted from Stephania tetrandra S. Moore.

Roslin 2 bromide is a p53 reactivator that disrupts the binding of FAK and p5Roslin …

PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, …

Fangchinoline is extracted from Stephania tetrandra S. Moore.

Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory …

Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation …

FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor …