FAK
Los inhibidores de la quinasa de adhesión focal (FAK) se dirigen a la FAK, una quinasa involucrada en la adhesión celular, la migración y la angiogénesis. La FAK está frecuentemente sobreexpresada en los tumores y contribuye a la formación de nuevos vasos sanguíneos que suministran nutrientes al tumor. Inhibir la FAK puede interrumpir estos procesos, lo que convierte a los inhibidores de la FAK en herramientas valiosas en la terapia contra el cáncer y la investigación de la angiogénesis. En CymitQuimica, ofrecemos una gama completa de inhibidores de FAK de alta calidad para apoyar su investigación en biología celular, cáncer y angiogénesis.
Se han encontrado 72 productos de "FAK"
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Chloropyramine hydrochloride
CAS:<p>Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.</p>Fórmula:C16H20ClN3·HClPureza:99.45% - 99.8%Forma y color:SolidPeso molecular:326.26ALK inhibitor 1
CAS:<p>ALK inhibitor 1 is a selective ALK kinase inhibitor.</p>Fórmula:C23H28BrN7O3SPureza:98.27%Forma y color:SolidPeso molecular:562.48ALK inhibitor 2
CAS:<p>ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.</p>Fórmula:C23H28ClN7O3SPureza:99.77% - >99.99%Forma y color:SolidPeso molecular:518.03Ifebemtinib FA
<p>BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.</p>Fórmula:C29H30F4N6O6Pureza:98.05% - 99.73%Forma y color:SolidPeso molecular:634.58Lewis y tetrasaccharide
CAS:<p>Lewis Y tetrasaccharide, a derivative of Lewis X, is an antigen linked to ovarian cancer metastasis and bad prognosis.</p>Fórmula:C26H45NO19Forma y color:SolidPeso molecular:675.63GSK215
CAS:<p>GSK215: potent, selective PROTAC degrader of FAK (pDC50=8.4), combines FAK inhibitor VS-4718 and VHL E3 ligase binder, causes fast, lasting FAK degradation.</p>Fórmula:C50H59F3N10O6SPureza:99.3%Forma y color:SoildPeso molecular:985.13Defactinib analogue-1
CAS:<p>Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.</p>Fórmula:C20H20F3N5O3SForma y color:SolidPeso molecular:467.47FAK PROTAC B5
CAS:<p>FAK PROTAC B5: a degrader with 14.9 nM IC50, strong degradation, anti-growth, good plasma stability, and fair permeability.</p>Fórmula:C41H43ClN10O7Forma y color:SolidPeso molecular:823.32119738-71-3
CAS:<p>Compound 2119738-71-3 interacts with the FAK receptor.</p>Fórmula:C25H29ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:513.99FAK-IN-9
CAS:<p>FAK-IN-9 (8f) is a potent oral FAK inhibitor, IC50 of 27.44 nM; induces TNBC cell apoptosis.</p>Fórmula:C36H38ClN7O8SForma y color:SolidPeso molecular:764.25FAK-IN-7
CAS:<p>FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.</p>Fórmula:C16H13N3OSPureza:98.18%Forma y color:SolidPeso molecular:295.36Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Forma y color:Odour SolidAdhesamine diTFA
CAS:<p>Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.</p>Fórmula:C28H32Cl2F6N8O6S2Forma y color:SolidPeso molecular:825.63VnP-16
<p>VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates</p>Fórmula:C82H112N20O17Pureza:98%Forma y color:SolidPeso molecular:1649.89FAK-IN-1
CAS:<p>FAK-IN-1 is a FAK inhibitor with anticancer activities (WO2020231726 (Example 27)).</p>Fórmula:C24H26F3N7O4SForma y color:SolidPeso molecular:565.57FAK-IN-10
CAS:<p>FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.</p>Fórmula:C15H10BrN3O2SPureza:99.78%Forma y color:SoildPeso molecular:376.23MLK3-IN-1
<p>MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.</p>Fórmula:C20H16F6N4O2SForma y color:SolidPeso molecular:490.422MY-1576
<p>MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.</p>Fórmula:C25H29ClN8O2Forma y color:SolidPeso molecular:509FAK-IN-27
<p>FAK-IN-27 (compound 8A) is a potent and selective inhibitor of FAK, with an IC50 of 4.968 nM. It effectively inhibits the proliferation of H1299 cells, with an IC50 of 0.28 μM, and is applicable for research in non-small cell lung cancer (NSCLC).</p>Fórmula:C32H28ClN5O6Forma y color:SolidPeso molecular:613.17281FAK-IN-14
CAS:<p>FAK-IN-14 is a FAK inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has a more significant inhibitory effect on FAK, FGFR1 and Pyk2.</p>Fórmula:C21H24BrN7OSPureza:99.7%Forma y color:SoildPeso molecular:502.43
