FAK
Los inhibidores de la quinasa de adhesión focal (FAK) se dirigen a la FAK, una quinasa involucrada en la adhesión celular, la migración y la angiogénesis. La FAK está frecuentemente sobreexpresada en los tumores y contribuye a la formación de nuevos vasos sanguíneos que suministran nutrientes al tumor. Inhibir la FAK puede interrumpir estos procesos, lo que convierte a los inhibidores de la FAK en herramientas valiosas en la terapia contra el cáncer y la investigación de la angiogénesis. En CymitQuimica, ofrecemos una gama completa de inhibidores de FAK de alta calidad para apoyar su investigación en biología celular, cáncer y angiogénesis.
Se han encontrado 72 productos de "FAK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Chloropyramine hydrochloride
CAS:<p>Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.</p>Fórmula:C16H20ClN3·HClPureza:99.45% - 99.8%Forma y color:SolidPeso molecular:326.26ALK inhibitor 1
CAS:<p>ALK inhibitor 1 is a selective ALK kinase inhibitor.</p>Fórmula:C23H28BrN7O3SPureza:98.27%Forma y color:SolidPeso molecular:562.48ALK inhibitor 2
CAS:<p>ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.</p>Fórmula:C23H28ClN7O3SPureza:99.77% - >99.99%Forma y color:SolidPeso molecular:518.03Lewis y tetrasaccharide
CAS:<p>Lewis Y tetrasaccharide, a derivative of Lewis X, is an antigen linked to ovarian cancer metastasis and bad prognosis.</p>Fórmula:C26H45NO19Forma y color:SolidPeso molecular:675.63FAK PROTAC B5
CAS:<p>FAK PROTAC B5: a degrader with 14.9 nM IC50, strong degradation, anti-growth, good plasma stability, and fair permeability.</p>Fórmula:C41H43ClN10O7Forma y color:SolidPeso molecular:823.3FAK-IN-11
<p>FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation.</p>Fórmula:C25H41NO3Pureza:98%Forma y color:SolidPeso molecular:403.6Ifebemtinib hydrochloride
<p>Ifebemtinib (BI-853520) hydrochloride is a potent FAK (focal adhesion kinase) inhibitor with oral bioavailability, exhibiting an IC50 of 1 nM for recombinant FAK. Ifebemtinib hydrochloride demonstrates antiproliferative activity against cancer cells.</p>Fórmula:C28H29ClF4N6O4Forma y color:SolidPeso molecular:625.01FAK-IN-15
<p>FAK-IN-15 is a highly potent focal adhesion kinase (FAK) inhibitor with antitumor activity.</p>Fórmula:C21H24ClN7OSPureza:99.08%Forma y color:SolidPeso molecular:457.98FAK-IN-12
<p>FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM.</p>Pureza:98%Forma y color:Odour SolidFAK-IN-14
CAS:<p>FAK-IN-14 is a FAK inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has a more significant inhibitory effect on FAK, FGFR1 and Pyk2.</p>Fórmula:C21H24BrN7OSPureza:99.7%Forma y color:SoildPeso molecular:502.43FAK-IN-7
CAS:<p>FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.</p>Fórmula:C16H13N3OSPureza:98.18%Forma y color:SolidPeso molecular:295.36Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Forma y color:Odour SolidIfebemtinib FA
<p>BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.</p>Fórmula:C29H30F4N6O6Pureza:98.05% - 99.73%Forma y color:SolidPeso molecular:634.58Adhesamine diTFA
CAS:<p>Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.</p>Fórmula:C28H32Cl2F6N8O6S2Forma y color:SolidPeso molecular:825.63MLK3-IN-1
<p>MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.</p>Fórmula:C20H16F6N4O2SForma y color:SolidPeso molecular:490.422MY-1576
<p>MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.</p>Fórmula:C25H29ClN8O2Forma y color:SolidPeso molecular:5092119738-71-3
CAS:<p>Compound 2119738-71-3 interacts with the FAK receptor.</p>Fórmula:C25H29ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:513.99FAK-IN-9
CAS:<p>FAK-IN-9 (8f) is a potent oral FAK inhibitor, IC50 of 27.44 nM; induces TNBC cell apoptosis.</p>Fórmula:C36H38ClN7O8SForma y color:SolidPeso molecular:764.25FAK-IN-1
CAS:<p>FAK-IN-1 is a FAK inhibitor with anticancer activities (WO2020231726 (Example 27)).</p>Fórmula:C24H26F3N7O4SForma y color:SolidPeso molecular:565.57Defactinib analogue-1
CAS:<p>Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.</p>Fórmula:C20H20F3N5O3SForma y color:SolidPeso molecular:467.47GSK215
CAS:<p>GSK215: potent, selective PROTAC degrader of FAK (pDC50=8.4), combines FAK inhibitor VS-4718 and VHL E3 ligase binder, causes fast, lasting FAK degradation.</p>Fórmula:C50H59F3N10O6SPureza:99.3%Forma y color:SoildPeso molecular:985.13VnP-16
<p>VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates</p>Fórmula:C82H112N20O17Pureza:98%Forma y color:SolidPeso molecular:1649.89FAK-IN-10
CAS:<p>FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.</p>Fórmula:C15H10BrN3O2SPureza:99.78%Forma y color:SoildPeso molecular:376.23FAK-IN-27
<p>FAK-IN-27 (compound 8A) is a potent and selective inhibitor of FAK, with an IC50 of 4.968 nM. It effectively inhibits the proliferation of H1299 cells, with an IC50 of 0.28 μM, and is applicable for research in non-small cell lung cancer (NSCLC).</p>Fórmula:C32H28ClN5O6Forma y color:SolidPeso molecular:613.17281Anti-PTK2 Antibody (4T687)
<p>Anti-PTK2 Antibody (4T687) is an antibody targeting PTK2. Anti-PTK2 Antibody (4T687) can be used in ELISA, IHC.</p>Forma y color:Odour LiquidConteltinib tetrahydrochloride
<p>Conteltinibtetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of Conteltinib. It acts as an inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. When used in combination with Cabozantinib, Conteltinib tetrahydrochloride exhibits a synergistic antitumor effect.</p>Fórmula:C32H49Cl4N9O3SForma y color:SolidPeso molecular:781.667BI-3663
CAS:<p>BI-3663 is a selective PTK2/FAK PROTAC with cereblon ligands, degrading PTK2 (IC50: 18 nM), and shows anti-cancer properties.</p>Fórmula:C44H42F3N7O12Pureza:98%Forma y color:SolidPeso molecular:917.84Y15
CAS:<p>Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,</p>Fórmula:C6H14Cl4N4Pureza:98% - 99.32%Forma y color:Dark Brown CrystalsPeso molecular:284.01SU6656
CAS:<p>SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.</p>Fórmula:C19H21N3O3SPureza:98.21% - 98.73%Forma y color:SolidPeso molecular:371.45Masitinib
CAS:<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Fórmula:C28H30N6OSPureza:97.56% - >99.99%Forma y color:SolidPeso molecular:498.64GSK2256098
CAS:<p>GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.</p>Fórmula:C20H23ClN6O2Pureza:99.46% - 99.74%Forma y color:SolidPeso molecular:414.89PF-431396
CAS:<p>PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).</p>Fórmula:C22H21F3N6O3SPureza:98.83% - 99.82%Forma y color:SolidPeso molecular:506.5Fangchinoline
CAS:<p>Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.</p>Fórmula:C37H40N2O6Pureza:99.86% - >99.99%Forma y color:SolidPeso molecular:608.72AMP-945
CAS:<p>AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.</p>Fórmula:C28H32F3N5O2Pureza:99.76%Forma y color:SolidPeso molecular:527.58PF-562271 hydrochloride
CAS:<p>PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.</p>Fórmula:C21H20F3N7O3SHClPureza:97.08%Forma y color:SolidPeso molecular:543.95PF-573228
CAS:<p>PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.</p>Fórmula:C22H20F3N5O3SPureza:96.58% - 99.51%Forma y color:SolidPeso molecular:491.49Nitidine chloride
CAS:<p>1.</p>Fórmula:C21H18ClNO4Pureza:96.59% - 98.91%Forma y color:SolidPeso molecular:383.82BI-4464
CAS:<p>BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC</p>Fórmula:C28H28F3N5O4Pureza:97.43%Forma y color:SolidPeso molecular:555.55Batatasin III
CAS:<p>Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer</p>Fórmula:C15H16O3Pureza:99.16%Forma y color:SolidPeso molecular:244.29Defactinib
CAS:<p>Defactinib (VS-6063) is a second-generation inhibitor of FAK. Defactinib has potential antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C20H21F3N8O3SPureza:98% - 99.71%Forma y color:SolidPeso molecular:510.49NVP-TAE 226
CAS:<p>NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.</p>Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Forma y color:SolidPeso molecular:468.94PF-562271 besylate
CAS:<p>PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.</p>Fórmula:C21H20F3N7O3S·C6H6O3SPureza:97.65% - 99.01%Forma y color:SolidPeso molecular:665.66PND-1186
CAS:<p>PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).</p>Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Forma y color:SolidPeso molecular:501.5CEP-37440
CAS:<p>CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).</p>Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Forma y color:SolidPeso molecular:580.12PF-562271
CAS:<p>PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).</p>Fórmula:C21H20F3N7O3SPureza:97.17% - >99.99%Forma y color:SolidPeso molecular:507.49FAK activator 1
CAS:<p>ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.</p>Fórmula:C23H26F3N3O3Pureza:99.19%Forma y color:SoildPeso molecular:449.47Y 11
CAS:<p>focal adhesion kinase (FAK) inhibitor</p>Fórmula:C8H17BrN4OPureza:98%Forma y color:SolidPeso molecular:265.15FAK-IN-8
CAS:<p>FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].</p>Fórmula:C15H9Cl2N3O2SForma y color:SolidPeso molecular:366.22TG53
CAS:<p>TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.</p>Fórmula:C21H22ClN5O2Pureza:98%Forma y color:SolidPeso molecular:411.88FLT3-IN-17
CAS:<p>FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.</p>Fórmula:C23H24N6O2S2Forma y color:SolidPeso molecular:480.61
