FAK
Los inhibidores de la quinasa de adhesión focal (FAK) se dirigen a la FAK, una quinasa involucrada en la adhesión celular, la migración y la angiogénesis. La FAK está frecuentemente sobreexpresada en los tumores y contribuye a la formación de nuevos vasos sanguíneos que suministran nutrientes al tumor. Inhibir la FAK puede interrumpir estos procesos, lo que convierte a los inhibidores de la FAK en herramientas valiosas en la terapia contra el cáncer y la investigación de la angiogénesis. En CymitQuimica, ofrecemos una gama completa de inhibidores de FAK de alta calidad para apoyar su investigación en biología celular, cáncer y angiogénesis.
Se han encontrado 72 productos de "FAK"
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ProMMP-9 inhibitor-3c
CAS:<p>ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.</p>Fórmula:C18H20FN3O2SForma y color:SolidPeso molecular:361.43FAK inhibitor 5
CAS:<p>FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.</p>Fórmula:C20H21N3O2SPureza:98%Forma y color:SolidPeso molecular:367.46NAMI-A
CAS:<p>NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.</p>Fórmula:C8H15Cl4N4ORuSPureza:98%Forma y color:SolidPeso molecular:458.18FAK inhibitor 2
CAS:<p>FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .</p>Fórmula:C29H33F3N8O2S2Forma y color:SolidPeso molecular:646.75Adhesamine
CAS:<p>Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.</p>Fórmula:C24H32Cl4N8O2S2Forma y color:SolidPeso molecular:670.51Defactinib hydrochloride
CAS:<p>Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.</p>Fórmula:C20H22ClF3N8O3SPureza:98.06% - 98.78%Forma y color:SolidPeso molecular:546.95Conteltinib
CAS:<p>Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.</p>Fórmula:C32H45N9O3SPureza:98.12% - 99.54%Forma y color:SolidPeso molecular:635.82Roslin 2 bromide
CAS:<p>Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.</p>Fórmula:C13H19BrN4Pureza:99.34%Forma y color:SolidPeso molecular:311.22FC 11
CAS:<p>FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.</p>Fórmula:C41H42F3N13O9SForma y color:SolidPeso molecular:949.91Ifebemtinib
CAS:<p>Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.</p>Fórmula:C28H28F4N6O4Pureza:98.84% - 99.85%Forma y color:SolidPeso molecular:588.55FAK-IN-21
CAS:<p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>Fórmula:C22H22F2N8O3SForma y color:SolidPeso molecular:516.52OXA-11
CAS:<p>OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.</p>Fórmula:C37H49F3N7O5PPureza:98.70% - 99.20%Forma y color:SolidPeso molecular:759.8FAK-IN-6
<p>FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.</p>Fórmula:C25H31ClN5O6PSForma y color:SolidPeso molecular:596.04FAK-IN-23
CAS:<p>FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).</p>Fórmula:C32H38F3N5O8Forma y color:SolidPeso molecular:677.668FAK inhibitor 6
CAS:<p>Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.</p>Fórmula:C25H24FN5O2SForma y color:SolidPeso molecular:477.55Pyk2-IN-2
CAS:<p>Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].</p>Fórmula:C27H27N7OForma y color:SolidPeso molecular:465.55FAK-IN-3
<p>FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.</p>Fórmula:C28H28N6O4Forma y color:SolidPeso molecular:512.56FAK-IN-26
CAS:<p>FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.</p>Fórmula:C20H19BrFN5O2Forma y color:SolidPeso molecular:460.30FAK inhibitor 7
CAS:<p>FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.</p>Fórmula:C32H37N7O3Forma y color:SolidPeso molecular:567.68JP-153
CAS:<p>JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.</p>Fórmula:C21H19NO5Forma y color:SolidPeso molecular:365.379Si306
CAS:<p>Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).</p>Fórmula:C25H26BrClN6OSForma y color:SolidPeso molecular:573.94PF-03814735
CAS:<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Fórmula:C23H25F3N6O2Pureza:98%Forma y color:SolidPeso molecular:474.48
