p53
Los inhibidores de p53 se dirigen a la proteína p53, un supresor tumoral que desempeña un papel crucial en la regulación del ciclo celular, la reparación del ADN y la apoptosis. Aunque p53 a menudo está mutado o inactivado en células cancerosas, su inhibición a veces es necesaria para proteger a las células sanas de la apoptosis durante ciertos tratamientos. Por otro lado, restaurar la función de p53 en los tumores puede conducir a la apoptosis de las células cancerosas. La investigación sobre inhibidores de p53 es compleja y significativa tanto para comprender los mecanismos del cáncer como para desarrollar nuevas terapias. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de p53 de alta calidad para apoyar su investigación en biología del cáncer, apoptosis y desarrollo terapéutico.
Se han encontrado 63 productos para "p53".
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MT 63-78
CAS:MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).Fórmula:C21H14N2O2Pureza:97.11% - 98.95%Forma y color:White SolidPeso molecular:326.35Ref: TM-T16156
1mg84,00€5mg160,00€1mL*10mM (DMSO)167,00€10mg260,00€25mg440,00€50mg628,00€100mg872,00€Etoposide
CAS:Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).Fórmula:C29H32O13Pureza:99.19% - 99.94%Forma y color:Crystals From Methanol SolidPeso molecular:588.56Unesbulin
CAS:Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).Fórmula:C19H13F5N6Pureza:98.71%Forma y color:SolidPeso molecular:420.34Amifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Fórmula:C5H15N2O3PSPureza:99.59% - 99.91%Forma y color:White SolidPeso molecular:214.22NSC-87877
CAS:NSC-87877 inhibits Shp2 (IC50=0.318μM), Shp1 (IC50=0.355μM), and DUSP26 phosphatases.Fórmula:C19H13N3O7S2Pureza:97.35%Forma y color:SolidPeso molecular:459.45Chlorambucil
CAS:Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.Fórmula:C14H19Cl2NO2Pureza:97.37% - 98.45%Forma y color:Off-White Slightly Granular Powder Melting Point 65-69°CPeso molecular:304.21Quinacrine dihydrochloride
CAS:Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplasticFórmula:C23H30CLN3O·2HClPureza:98.24% - 99.80%Forma y color:Yellow Crystals Or PowderPeso molecular:472.88Apoptosis Compound Library
A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;Forma y color:Odour SolidRef: TM-L9000
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarTetrofosmin
CAS:Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.Fórmula:C18H40O4P2Forma y color:SolidPeso molecular:382.46ReACp53 acetate
ReACp53 acetate could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.Fórmula:C110H210N52O26Pureza:99.51%Forma y color:SolidPeso molecular:2677.18Transcription Factor-Targeted Compound Library
Well-chosen xnum compounds with unique structures targeting transcription factor;Forma y color:Odour SolidRef: TM-L1380
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarp53 (17-26)
CAS:Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.Fórmula:C60H90N12O17Pureza:98%Forma y color:SolidPeso molecular:1251.43UNC 0631
CAS:UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).Fórmula:C37H61N7O2Pureza:97.42%Forma y color:SolidPeso molecular:635.93BMH-7 HCl
BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.Fórmula:C20H22ClN5OPureza:99.62%Forma y color:SolidPeso molecular:383.88HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Forma y color:Lyophilized PowderPeso molecular:The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.Anti-p53 Antibody (9D896)
Anti-p53 Antibody (9D896) is an antibody targeting p53. Anti-p53 Antibody (9D896) can be used in ELISA, WB, IHC, IF.Forma y color:Odour LiquidAnti-p53 Antibody (2H232)
Anti-p53 Antibody (2H232) is an antibody targeting p53. Anti-p53 Antibody (2H232) can be used in ELISA, IHC.Forma y color:Odour LiquidAnti-p53 Antibody (3K688)
Anti-p53 Antibody (3K688) is a Rabbit antibody targeting p53. Anti-p53 Antibody (3K688) can be used in WB,ELISA,IP.Forma y color:Odour LiquidAnti-p53 Antibody (9G129)
Anti-p53 Antibody (9G129) is a Rabbit antibody targeting p53. Anti-p53 Antibody (9G129) can be used in IHC-P,ICC/IF.Forma y color:Odour LiquidAnti-p53 Antibody (9G324)
Anti-p53 Antibody (9G324) is an antibody targeting p53. Anti-p53 Antibody (9G324) can be used in ELISA, IF.Forma y color:Odour LiquidAnti-Phospho-TP53 (Ser392) Antibody (7W136)
Anti-Phospho-TP53 (Ser392) Antibody (7W136) is an antibody targeting Phospho-TP53 (Ser392). Anti-Phospho-TP53 (Ser392) Antibody (7W136) can be used in ELISA, WB.Forma y color:Odour LiquidAnti-p53 Antibody (1J151)
Anti-p53 Antibody (1J151) is a Mouse antibody targeting p53. Anti-p53 Antibody (1J151) can be used in ELISA(Cap).Forma y color:Odour LiquidAnti-p53 Antibody (8M251)
Anti-p53 Antibody (8M251) is an antibody targeting p53. Anti-p53 Antibody (8M251) can be used in ELISA, WB, IHC, IF.Forma y color:Odour LiquidAnti-Phospho-TP53 (Thr55) Antibody (8C690)
Anti-Phospho-TP53 (Thr55) Antibody (8C690) is an antibody targeting Phospho-TP53 (Thr55). Anti-Phospho-TP53 (Thr55) Antibody (8C690) can be used in ELISA, WB, IF.Forma y color:Odour LiquidAnti-Phospho-TP53 (Ser33) Antibody (4K787)
Anti-Phospho-TP53 (Ser33) Antibody (4K787) is an antibody targeting Phospho-TP53 (Ser33). Anti-Phospho-TP53 (Ser33) Antibody (4K787) can be used in ELISA, IHC, IF.Forma y color:Odour LiquidAnti-p53 Antibody (2V863)
Anti-p53 Antibody (2V863) is a Mouse antibody targeting p53. Anti-p53 Antibody (2V863) can be used in ELISA,ELISA(Det).Forma y color:Odour LiquidAnti-Phospho-TP53 (Ser9) Antibody (4M602)
Anti-Phospho-TP53 (Ser9) Antibody (4M602) is an antibody targeting Phospho-TP53 (Ser9). Anti-Phospho-TP53 (Ser9) Antibody (4M602) can be used in ELISA, IF.Forma y color:Odour LiquidAnti-p53 Antibody (8C308)
Anti-p53 Antibody (8C308) is an antibody targeting p53. Anti-p53 Antibody (8C308) can be used in ELISA, WB, IF, FCM.Forma y color:Odour LiquidMethylstat
CAS:Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.Fórmula:C28H31N3O6Pureza:98.34% - 98.34%Forma y color:White SolidPeso molecular:505.56p53 Protein, Cynomolgus, Recombinant
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family.Forma y color:Lyophilized PowderPeso molecular:43.7 kDa (predicted); 48 kDa (reducing conditions)HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
p53 is a tumor suppressor protein.Forma y color:Lyophilized PowderPeso molecular:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Forma y color:Lyophilized PowderPeso molecular:The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Forma y color:Lyophilized PowderPeso molecular:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
p53 is a tumor suppressor protein.Forma y color:Lyophilized PowderPeso molecular:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
p53 is a tumor suppressor protein.Forma y color:Odour Lyophilized PowderHLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi)
p53 is a tumor suppressor protein.Forma y color:Lyophilized PowderPeso molecular:The protein has a predicted MW of 50.5 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
p53 is a tumor suppressor protein.Forma y color:Odour Lyophilized PowderProteasome inhibitor IX
CAS:Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).Fórmula:C20H21B2NO5Pureza:99.77%Forma y color:SolidPeso molecular:377.01LLY-507
CAS:LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Fórmula:C36H42N6OPureza:99.58% - 99.93%Forma y color:White SolidPeso molecular:574.76Ref: TM-T6879
1mg42,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)104,00€10mg131,00€25mg289,00€50mg522,00€100mg747,00€KCC-07
CAS:KCC-07: Selective, potent, brain-penetrant MBD2 inhibitor with anticancer effects, blocking MBD2-DNA binding and activating BAI1 signaling.Fórmula:C14H11N3OSPureza:98.86% - 99.01%Forma y color:SolidPeso molecular:269.32Ref: TM-T8554
1mg35,00€5mg71,00€1mL*10mM (DMSO)73,00€10mg112,00€25mg212,00€50mg335,00€100mg500,00€200mg712,00€UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Fórmula:C36H59N7O2Pureza:>99.99%Forma y color:SolidPeso molecular:621.9Schisandrol B
CAS:Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.Fórmula:C23H28O7Pureza:99.14% - 99.95%Forma y color:SolidPeso molecular:416.46Ref: TM-T6S1917
5mg67,00€1mL*10mM (DMSO)74,00€10mg90,00€25mg190,00€50mg286,00€100mg429,00€500mg982,00€XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Fórmula:C48H57ClN8O5Pureza:98.75% - 99.49%Forma y color:Yellow SolidPeso molecular:861.47BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Fórmula:C28H38N6O2Pureza:98.58% - 99.64%Forma y color:SolidPeso molecular:490.64Ref: TM-T7697
1mg38,00€5mg80,00€10mg111,00€1mL*10mM (DMSO)124,00€25mg197,00€50mg295,00€100mg447,00€200mg607,00€NSC-87877 disodium
CAS:NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.Fórmula:C19H13N3O7S2·2NaPureza:97.89%Forma y color:SolidPeso molecular:503.42(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Fórmula:C20H16N2O5Pureza:99.09% - 99.81%Forma y color:SolidPeso molecular:364.35NSC348884
CAS:NSC348884, a nucleophosmin inhibitor, disrupts oligomers, induces apoptosis, and inhibits cancer cell growth (IC50: 1.7-4.0 μM).Fórmula:C38H40N10Pureza:98.69% - 99.91%Forma y color:SolidPeso molecular:636.79Ref: TM-T6909
2mg39,00€5mg58,00€1mL*10mM (DMSO)80,00€10mg90,00€25mg172,00€50mg280,00€100mg405,00€500mg888,00€Lumichrome
CAS:Lumichrome, a riboflavin metabolite, influences plant growth, ascidian metamorphosis, bacterial communication, and blocks riboflavin uptake.Fórmula:C12H10N4O2Pureza:99.69% - 99.93%Forma y color:Yellow SolidPeso molecular:242.23XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Fórmula:C11H13N5O4Pureza:99.51%Forma y color:SolidPeso molecular:279.25Ref: TM-T6610
1mg52,00€2mg77,00€1mL*10mM (DMSO)108,00€5mg113,00€10mg177,00€25mg409,00€50mg605,00€100mg860,00€500mg1.728,00€cjoc42
CAS:Cjoc42 blocks gankyrin to prevent p53 reduction, aiding cancer prevention and DNA damage response.Fórmula:C20H21N3O5SPureza:99.56%Forma y color:SolidPeso molecular:415.46Ref: TM-T27029
1mg60,00€5mg133,00€1mL*10mM (DMSO)152,00€10mg193,00€25mg349,00€50mg522,00€100mg730,00€200mg982,00€
