p53
Los inhibidores de p53 se dirigen a la proteína p53, un supresor tumoral que desempeña un papel crucial en la regulación del ciclo celular, la reparación del ADN y la apoptosis. Aunque p53 a menudo está mutado o inactivado en células cancerosas, su inhibición a veces es necesaria para proteger a las células sanas de la apoptosis durante ciertos tratamientos. Por otro lado, restaurar la función de p53 en los tumores puede conducir a la apoptosis de las células cancerosas. La investigación sobre inhibidores de p53 es compleja y significativa tanto para comprender los mecanismos del cáncer como para desarrollar nuevas terapias. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de p53 de alta calidad para apoyar su investigación en biología del cáncer, apoptosis y desarrollo terapéutico.
Se han encontrado 62 productos de "p53"
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XL177A
CAS:<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Fórmula:C48H57ClN8O5Pureza:98.75%Forma y color:SolidPeso molecular:861.47Schisandrol B
CAS:<p>Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.</p>Fórmula:C23H28O7Pureza:99.14% - 99.95%Forma y color:SolidPeso molecular:416.46BIX-01294
CAS:<p>BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).</p>Fórmula:C28H38N6O2Pureza:98.58% - 99.64%Forma y color:SolidPeso molecular:490.64NSC-87877 disodium
CAS:<p>NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.</p>Fórmula:C19H13N3O7S2·2NaPureza:97.89%Forma y color:SolidPeso molecular:503.42NSC 66811
CAS:<p>NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.</p>Fórmula:C23H20N2OPureza:96.94%Forma y color:SolidPeso molecular:340.42(S)-10-Hydroxycamptothecin
CAS:<p>(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.</p>Fórmula:C20H16N2O5Pureza:99.09% - 99.81%Forma y color:SolidPeso molecular:364.35NSC348884
CAS:<p>NSC348884, a nucleophosmin inhibitor, disrupts oligomers, induces apoptosis, and inhibits cancer cell growth (IC50: 1.7-4.0 μM).</p>Fórmula:C38H40N10Pureza:98.69% - 99.91%Forma y color:SolidPeso molecular:636.79Lumichrome
CAS:<p>Lumichrome, a riboflavin metabolite, influences plant growth, ascidian metamorphosis, bacterial communication, and blocks riboflavin uptake.</p>Fórmula:C12H10N4O2Pureza:99.69% - 99.93%Forma y color:SolidPeso molecular:242.23XI-006
CAS:<p>NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.</p>Fórmula:C11H13N5O4Pureza:99.51%Forma y color:SolidPeso molecular:279.25cjoc42
CAS:<p>Cjoc42 blocks gankyrin to prevent p53 reduction, aiding cancer prevention and DNA damage response.</p>Fórmula:C20H21N3O5SPureza:99.56%Forma y color:SolidPeso molecular:415.46Amifostine trihydrate
CAS:<p>Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.</p>Fórmula:C5H15N2O3PS·3H2OPureza:99.71% - 99.80%Forma y color:SolidPeso molecular:268.27Leptomycin B
CAS:<p>Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.</p>Fórmula:C33H48O6Pureza:97.10% - 99.04%Forma y color:White Crystalline SolidPeso molecular:540.73BIX-01294 trihydrochloride
CAS:<p>BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.</p>Fórmula:C28H38N6O2·3HClPureza:99.41% - 99.95%Forma y color:SolidPeso molecular:600.02Theaflavin 3,3′-digallate
CAS:<p>Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer</p>Fórmula:C43H32O20Pureza:98.71% - 99.86%Forma y color:SolidPeso molecular:868.7Nutlin-3a
CAS:<p>Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C30H30Cl2N4O4Pureza:95.62% - 99.71%Forma y color:SolidPeso molecular:581.49YK-3-237
CAS:<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>Fórmula:C19H21BO7Pureza:99.47%Forma y color:SolidPeso molecular:372.18O6-Benzylguanine
CAS:<p>O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.</p>Fórmula:C12H11N5OPureza:98.9%Forma y color:Solid CrystallinePeso molecular:241.25UNC0224
CAS:<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Fórmula:C26H43N7O2Pureza:99.80%Forma y color:SolidPeso molecular:485.67NSC 146109 hydrochloride
CAS:<p>NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.</p>Fórmula:C17H17ClN2SPureza:99.28%Forma y color:SolidPeso molecular:316.85UNC0321
CAS:<p>UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.</p>Fórmula:C27H45N7O3Pureza:99.80%Forma y color:SolidPeso molecular:515.69
