Chk
Los inhibidores de la quinasa de control de ciclo (Chk) se dirigen a las quinasas Chk1 y Chk2, que son reguladores clave de la respuesta al daño del ADN y los puntos de control del ciclo celular. Estas quinasas detienen la progresión del ciclo celular en respuesta al daño en el ADN, permitiendo tiempo para la reparación. Inhibir las quinasas Chk puede evitar el arresto del ciclo celular, forzando a las células dañadas a continuar con el ciclo y, finalmente, someterse a apoptosis. Los inhibidores de Chk son particularmente valiosos en la investigación del cáncer, donde pueden sensibilizar las células tumorales a los agentes que dañan el ADN. En CymitQuimica, ofrecemos una variedad de inhibidores de Chk de alta calidad para apoyar su investigación en la respuesta al daño del ADN, la regulación del ciclo celular y la oncología.
Se han encontrado 42 productos de "Chk"
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CHK1-IN-4 hydrochloride
<p>CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).</p>Fórmula:C18H19BrClN7O2Pureza:99.29%Forma y color:SoildPeso molecular:480.75Monalizumab
CAS:<p>Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.</p>Pureza:95% - > 95%Forma y color:LiquidPeso molecular:147 kDa (average)WAY-230563
CAS:<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Fórmula:C17H12N2O2SPureza:98.40%Forma y color:SolidPeso molecular:308.35CBP501 Affinity Peptide
CAS:<p>CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].</p>Fórmula:C68H119N21O25SForma y color:SolidPeso molecular:1662.86Zimistobart
CAS:<p>Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Forma y color:LiquidCCT241533 dihydrochloride
CAS:<p>Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.</p>Fórmula:C23H29Cl2FN4O4Forma y color:SolidPeso molecular:515.41Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Fórmula:C16H18F3N7Forma y color:SolidPeso molecular:365.364CHK1-IN-12
<p>CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.</p>Fórmula:C19H19N7O2Forma y color:SolidPeso molecular:377.16002CHK1-IN-9
<p>CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.</p>CCT244747
CAS:<p>CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .</p>Fórmula:C20H24N8O2Pureza:99.17%Forma y color:SolidPeso molecular:408.46GDC-0425
CAS:<p>GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.</p>Fórmula:C18H19N5OForma y color:SolidPeso molecular:321.38GDC-0575 dihydrochloride
CAS:<p>GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.</p>Fórmula:C16H22BrCl2N5OForma y color:SolidPeso molecular:451.19LY2880070
CAS:<p>LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.</p>Fórmula:C19H23N7O2Pureza:99.77%Forma y color:SolidPeso molecular:381.43GDC-0575
CAS:<p>GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).</p>Fórmula:C16H20BrN5OPureza:≥95%Forma y color:SolidPeso molecular:378.27SCH900776
CAS:<p>SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.</p>Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Forma y color:SolidPeso molecular:376.25GDC0575 monohydrochloride
CAS:<p>GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.</p>Fórmula:C16H21BrClN5OPureza:97.85%Forma y color:SolidPeso molecular:414.73SAR-020106
CAS:<p>SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.</p>Fórmula:C19H19ClN6OPureza:97.78%Forma y color:SolidPeso molecular:382.85Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Fórmula:C18H22BrN5O3Pureza:98.86% - 99.87%Forma y color:SolidPeso molecular:436.3CCT245737
CAS:<p>CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.</p>Fórmula:C16H16F3N7OPureza:98.06% - 99.69%Forma y color:SolidPeso molecular:379.34AZD-7762
CAS:<p>AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.</p>Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Forma y color:SolidPeso molecular:362.42AZD7762 HCl
CAS:<p>AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.</p>Fórmula:C17H20ClFN4O2SPureza:98%Forma y color:SolidPeso molecular:398.88PV-1115
CAS:<p>PV-1115 is an effective and highly selective inhibitor of the Chk2.</p>Fórmula:C20H19N7O3Pureza:98%Forma y color:SolidPeso molecular:405.41NSC 109555 ditosylate
CAS:<p>Chk2 inhibitor,ATP-competitive</p>Fórmula:C26H32N10O4SPureza:98%Forma y color:SolidPeso molecular:580.66PV-1019
CAS:<p>PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.</p>Fórmula:C18H17N7O3Forma y color:SolidPeso molecular:379.37VRX-0466617
CAS:<p>VRX-0466617 is a novel selective Chk2 inhibitor.</p>Fórmula:C19H20BrN5O2SForma y color:SolidPeso molecular:462.36TCS 2312
CAS:<p>checkpoint kinase 1 (chk1) inhibitor</p>Fórmula:C25H24N4O2Pureza:98%Forma y color:SolidPeso molecular:412.48SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Fórmula:C15H13N5O2Pureza:98%Forma y color:SolidPeso molecular:295.3M443
CAS:<p>M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.</p>Fórmula:C31H30F3N7O2Pureza:98.95%Forma y color:SolidPeso molecular:589.61NR2F6 modulator-1
CAS:<p>NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.</p>Fórmula:C23H17NO5SPureza:98.31%Forma y color:SolidPeso molecular:419.45CHK1-IN-3
CAS:<p>CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).</p>Fórmula:C20H23N9OPureza:98.78%Forma y color:SolidPeso molecular:405.46CCT241533 hydrochloride
CAS:<p>CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Fórmula:C23H28ClFN4O4Pureza:97.13%Forma y color:SolidPeso molecular:478.95MU-380
CAS:<p>MU-380 is an effective and selective inhibitor of CHK1.</p>Fórmula:C15H15BrF3N7Forma y color:SolidPeso molecular:430.23CCT241533
CAS:<p>CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Fórmula:C23H27FN4O4Pureza:98%Forma y color:SolidPeso molecular:442.48VER-00158411
CAS:<p>VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).</p>Fórmula:C31H34N6O3Pureza:98%Forma y color:SolidPeso molecular:538.64CHK1-IN-2
CAS:<p>CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).</p>Fórmula:C20H22N4OSPureza:98%Forma y color:SolidPeso molecular:366.48CHK1-IN-4
CAS:<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Fórmula:C18H18BrN7O2Pureza:98%Forma y color:SolidPeso molecular:444.29CHK-IN-1
CAS:<p>CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.</p>Fórmula:C18H19ClFN5OSPureza:>99.99%Forma y color:SolidPeso molecular:407.89BBI-355
CAS:<p>BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.</p>Fórmula:C19H19N7O2Forma y color:SolidPeso molecular:377.40CHK1-IN-11
CAS:<p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>Fórmula:C20H22N8O2Forma y color:SolidPeso molecular:406.44CHK1 inhibitor
CAS:<p>CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.</p>Fórmula:C17H21BrN4OPureza:98%Forma y color:SolidPeso molecular:377.28Chk1-IN-5
CAS:<p>Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.</p>Fórmula:C18H18FN7O2Forma y color:SolidPeso molecular:383.38PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Fórmula:C19H19FN4O2SPureza:99.4%Forma y color:SolidPeso molecular:386.44
