Chk
Los inhibidores de la quinasa de control de ciclo (Chk) se dirigen a las quinasas Chk1 y Chk2, que son reguladores clave de la respuesta al daño del ADN y los puntos de control del ciclo celular. Estas quinasas detienen la progresión del ciclo celular en respuesta al daño en el ADN, permitiendo tiempo para la reparación. Inhibir las quinasas Chk puede evitar el arresto del ciclo celular, forzando a las células dañadas a continuar con el ciclo y, finalmente, someterse a apoptosis. Los inhibidores de Chk son particularmente valiosos en la investigación del cáncer, donde pueden sensibilizar las células tumorales a los agentes que dañan el ADN. En CymitQuimica, ofrecemos una variedad de inhibidores de Chk de alta calidad para apoyar su investigación en la respuesta al daño del ADN, la regulación del ciclo celular y la oncología.
Se han encontrado 42 productos de "Chk"
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AZD7762 HCl
CAS:<p>AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.</p>Fórmula:C17H20ClFN4O2SPureza:98%Forma y color:SolidPeso molecular:398.88PV-1115
CAS:<p>PV-1115 is an effective and highly selective inhibitor of the Chk2.</p>Fórmula:C20H19N7O3Pureza:98%Forma y color:SolidPeso molecular:405.41NSC 109555 ditosylate
CAS:<p>Chk2 inhibitor,ATP-competitive</p>Fórmula:C26H32N10O4SPureza:98%Forma y color:SolidPeso molecular:580.66PV-1019
CAS:<p>PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.</p>Fórmula:C18H17N7O3Forma y color:SolidPeso molecular:379.37VRX-0466617
CAS:<p>VRX-0466617 is a novel selective Chk2 inhibitor.</p>Fórmula:C19H20BrN5O2SForma y color:SolidPeso molecular:462.36TCS 2312
CAS:<p>checkpoint kinase 1 (chk1) inhibitor</p>Fórmula:C25H24N4O2Pureza:98%Forma y color:SolidPeso molecular:412.48SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Fórmula:C15H13N5O2Pureza:98%Forma y color:SolidPeso molecular:295.3M443
CAS:<p>M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.</p>Fórmula:C31H30F3N7O2Pureza:98.95%Forma y color:SolidPeso molecular:589.61NR2F6 modulator-1
CAS:<p>NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.</p>Fórmula:C23H17NO5SPureza:98.31%Forma y color:SolidPeso molecular:419.45CHK1-IN-3
CAS:<p>CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).</p>Fórmula:C20H23N9OPureza:98.78%Forma y color:SolidPeso molecular:405.46CCT241533 hydrochloride
CAS:<p>CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Fórmula:C23H28ClFN4O4Pureza:97.13%Forma y color:SolidPeso molecular:478.95MU-380
CAS:<p>MU-380 is an effective and selective inhibitor of CHK1.</p>Fórmula:C15H15BrF3N7Forma y color:SolidPeso molecular:430.23CCT241533
CAS:<p>CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Fórmula:C23H27FN4O4Pureza:98%Forma y color:SolidPeso molecular:442.48VER-00158411
CAS:<p>VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).</p>Fórmula:C31H34N6O3Pureza:98%Forma y color:SolidPeso molecular:538.64CHK1-IN-2
CAS:<p>CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).</p>Fórmula:C20H22N4OSPureza:98%Forma y color:SolidPeso molecular:366.48CHK1-IN-4
CAS:<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Fórmula:C18H18BrN7O2Pureza:98%Forma y color:SolidPeso molecular:444.29CHK-IN-1
CAS:<p>CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.</p>Fórmula:C18H19ClFN5OSPureza:>99.99%Forma y color:SolidPeso molecular:407.89BBI-355
CAS:<p>BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.</p>Fórmula:C19H19N7O2Forma y color:SolidPeso molecular:377.40CHK1-IN-11
CAS:<p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>Fórmula:C20H22N8O2Forma y color:SolidPeso molecular:406.44CHK1 inhibitor
CAS:<p>CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.</p>Fórmula:C17H21BrN4OPureza:98%Forma y color:SolidPeso molecular:377.28
