Kinesina
Los inhibidores de cinesina se dirigen a las proteínas motoras cinesinas, responsables del transporte de carga celular a lo largo de los microtúbulos y que desempeñan un papel clave en la división celular, especialmente durante la mitosis. Las cinesinas están involucradas en el movimiento de cromosomas y otros orgánulos durante la división celular. Inhibir las cinesinas puede interrumpir estos procesos, lo que lleva al arresto del ciclo celular y a la posible muerte celular, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer. En CymitQuimica, ofrecemos una gama diversa de inhibidores de cinesina de alta calidad para apoyar su investigación en biología celular, mitosis y terapia contra el cáncer.
Se han encontrado 89 productos para "Kinesina".
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Mitotic kinesin-IN-1 hydrochloride
CAS:Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Fórmula:C22H26ClF2N3OSForma y color:SolidPeso molecular:453.98RMS-07
CAS:RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Fórmula:C35H40N8O2Forma y color:SolidPeso molecular:604.74EX05
CAS:EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.Fórmula:C26H30F2N4O5SForma y color:SolidPeso molecular:548.60MKLP2-IN-1
CAS:MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.Fórmula:C23H19BrFN3O2Forma y color:SolidPeso molecular:468.318KIF18A-IN-18
CAS:KIF18A-IN-18 (Compound I) serves as an inhibitor of KIF18A and is applicable in studies of tumors characterized by chromosomal instability.Fórmula:C29H34F2N4O5SPeso molecular:588.67CCT368772
CAS:CCT368772 (compound 35) is a selective inhibitor of the kinesin protein HSET, with an HSET ADP-GloIC50 of 0.019 μM. It demonstrates specificity for HSET over Eg5, as shown by an Eg5 ADP-GloIC50 value greater than 200 μM. CCT368772 (compound 152) can be utilized in the study of hyperproliferative diseases and disorders such as cancer.Fórmula:C25H32N6O5SPeso molecular:528.63AM-9022
CAS:AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].Fórmula:C27H36F2N6O4SForma y color:SolidPeso molecular:578.67TTK inhibitor 4
CAS:TTK inhibitor 4 (compound 16) acts as a potent threonine tyrosine kinase (TTK) inhibitor, exhibiting an IC 50 value of 0.016 μM and demonstrating anti-tumor activity [1].Fórmula:C25H29N9OForma y color:SolidPeso molecular:471.56Cenpemlin
CAS:Cenpemlin is a CENP-M inhibitor that disrupts the interaction between CENP-M and CENP-L. It is useful for studying centromere-kinetochore interactions and the dynamic assembly of kinetochores during cell division.Fórmula:C17H29N7O7Peso molecular:443.46
