Integrin
Los inhibidores de integrinas se dirigen a las integrinas, una familia de receptores en la superficie celular que desempeñan un papel crucial en la adhesión celular, la migración y la transducción de señales. Las integrinas están involucradas en la regulación del ciclo celular, particularmente en procesos como la división y la diferenciación celular. Inhibir las integrinas puede interrumpir estos procesos, lo que lleva al arresto del ciclo celular y la apoptosis, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer y el estudio de la metástasis. En CymitQuimica, ofrecemos una amplia gama de inhibidores de integrinas de alta calidad para apoyar su investigación en la regulación del ciclo celular, la biología del cáncer y el desarrollo terapéutico.
Se han encontrado 278 productos de "Integrin"
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Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Fórmula:C27H40N8O7Pureza:98% - 99.8%Forma y color:SolidPeso molecular:588.66ILK-IN-2
CAS:ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.Fórmula:C30H30F3N5OPureza:99.30%Forma y color:SolidPeso molecular:533.59Ref: TM-T5488
1mg46,00€5mg92,00€10mg122,00€1mL*10mM (DMSO)130,00€25mg154,00€50mg182,00€100mg266,00€200mg386,00€Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.
Fórmula:C29H24Cl2N2O7SPureza:99.39% - 99.66%Forma y color:SolidPeso molecular:615.48Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Fórmula:C32H46O8Pureza:97.1% - 99.93%Forma y color:SolidPeso molecular:558.70ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Fórmula:C10H12N6OPureza:99.69%Forma y color:SolidPeso molecular:232.24iRGD peptide
CAS:iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Fórmula:C35H57N13O14S2Pureza:98.77%Forma y color:SolidPeso molecular:948.04roxifiban
CAS:Roxifiban, a prodrug of XV459, is an antiplatelet agent with high affinity and specificity for platelet glycoprotein IIb/IIIa complex(GPIIb/IIIa) receptors.
Fórmula:C21H29N5O6Pureza:98%Forma y color:SolidPeso molecular:447.48Hexapeptide-10 Acetate
Hexapeptide-10 Acetate (Hexapeptide-10 Acetate) is a synthetic peptide.Fórmula:C30H57N7O10Pureza:98.84%Forma y color:SolidPeso molecular:675.81Emvistegrast
CAS:Emvistegrast is a quinolone derivative that acts as an antagonist for the α4β7 integrin.Fórmula:C35H32F4N6O6Forma y color:SolidPeso molecular:708.66Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Fórmula:C28H26Cl2N4O5Pureza:99.26% - 99.72%Forma y color:SolidPeso molecular:569.44HSDVHK-NH2 acetate
P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).Fórmula:C32H52N12O11Pureza:99.5%Forma y color:SolidPeso molecular:780.39Arg-Gly-Asp TFA (99896-85-2(free base))
Arg-Gly-Asp TFA (RGD, 99896-85-2) is a tripeptide that promotes cell adhesion and integrin binding.Fórmula:C14H23F3N6O8Pureza:99.2% - ≥98%Forma y color:SolidPeso molecular:460.36Irigenin
CAS:Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFórmula:C18H16O8Pureza:99.50% - 99.85%Forma y color:SolidPeso molecular:360.31Cyclo(RADfK)
CAS:Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Fórmula:C28H43N9O7Pureza:>99.99%Forma y color:SolidPeso molecular:617.7Orbofiban
CAS:Orbofiban, an orally administered antagonist of the platelet GPIIb/IIIa receptor, effectively inhibits platelet aggregation.Fórmula:C17H23N5O4Forma y color:SolidPeso molecular:361.4A-286982
CAS:A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Fórmula:C24H27N3O4SPureza:97.81%Forma y color:SolidPeso molecular:453.55Ref: TM-T21781
1mg34,00€2mg48,00€5mg71,00€1mL*10mM (DMSO)77,00€10mg102,00€25mg200,00€50mg333,00€100mg495,00€PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Forma y color:SolidPeso molecular:501.5Carotegrast methyl HCl
CAS:Carotegrast methyl (AJM300/PTC-100) is an oral α4 integrin blocker reducing inflammation and experimental colitis.Fórmula:C25H20Cl3N3O5Forma y color:SolidPeso molecular:548.801Eptifibatide acetate (148031-34-9 free base)
CAS:Eptifibatide acetate (148031-34-9), a cyclic heptapeptide GP IIb/IIIa inhibitor antiplatelet drug.Fórmula:C35H49N11O9S2·xC2H4O2Pureza:99.7% - 99.87%Forma y color:SolidPeso molecular:891.01Tirofiban hydrochloride monohydrate
CAS:Tirofiban（MK383） hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.Fórmula:C22H39ClN2O6SPureza:98.81% - >99.99%Forma y color:White SolidPeso molecular:495.07Leukadherin-1
CAS:Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.Fórmula:C22H15NO4S2Pureza:98.49% - 98.93%Forma y color:SolidPeso molecular:421.49CWHM-12
CAS:CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Fórmula:C26H32BrN5O6Pureza:98.05% - 99.83%Forma y color:SolidPeso molecular:590.47Ref: TM-TQ0250
1mg40,00€2mg52,00€5mg88,00€1mL*10mM (DMSO)96,00€10mg126,00€25mg221,00€50mg369,00€100mg550,00€Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Fórmula:C31H43F6N9O12Pureza:95.28% - ≥95%Forma y color:SolidPeso molecular:847.72α2β1 Integrin Ligand Peptide acetate
α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) is a potential antagonist of α2β1 integrin receptor.Fórmula:C16H26N4O11Pureza:98.46%Forma y color:SolidPeso molecular:450.4Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Fórmula:C23H25N5O3SPureza:99.19%Forma y color:SolidPeso molecular:451.54Ref: TM-T16695
1mg78,00€2mg90,00€5mg150,00€1mL*10mM (DMSO)165,00€10mg215,00€25mg385,00€50mg595,00€100mg858,00€Cyclo(-RGDfK)
CAS:Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.Fórmula:C27H41N9O7Pureza:95.29% - >99.99%Forma y color:SolidPeso molecular:603.67H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Fórmula:C23H38N10O10Pureza:>99.99%Forma y color:SolidPeso molecular:614.61Arg-Gly-Asp-Ser
CAS:Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found in fibronectin, and the von Willebrand factor.Fórmula:C15H27N7O8Pureza:98.29%Forma y color:SolidPeso molecular:433.42RO0270608
CAS:RO0270608 is an α4β1/α4β7 integrin antagonist with anti-inflammatory activity for the study of allergic inflammatory responses.Fórmula:C24H19Cl3N2O4Pureza:98.26%Forma y color:SolidPeso molecular:505.78Bexotegrast
CAS:Bexotegrast (PLN-74809) is an αvβ6 and αvβ1 integrin inhibitor with antifibrotic properties for the study of idiopathic pulmonary fibrosis (IPF).Fórmula:C27H36N6O3Pureza:99.53%Forma y color:SolidPeso molecular:492.61Vepsitamab
CAS:Vepsitamab (AMG 199), an anti-MUC17/CD3 BiTE, targets T cells and tumors for cell lysis and T cell activation.Forma y color:LiquidVixtimotamab
Vixtimotamab (AMV-564; TandAb T564), a bispecific tetravalent tandem diabody (TandAb), selectively engages human CD33 and CD3 antigens.Forma y color:Odour LiquidGresonitamab
CAS:Gresonitamab (AMG 910) is an HLE BiTE antibody targeting CD3+ T cells and CLDN18.2+ tumors, for adenocarcinoma research.Forma y color:LiquidPavurutamab
CAS:Pavurutamab (AMG-701) is a bispecific T cell engager targeting CD3 and BCMA with extended half-life, designed to treat MM.Forma y color:LiquidAnti-Mouse CD32/CD16 Antibody (2.4G2)
Anti-Mouse CD32/CD16 Antibody is a rat-derived IgG2b inhibitor targeting the mouse CD32/CD16 antigens.Forma y color:Odour LiquidPeso molecular:150 kDaVoxalatamab
CAS:Voxalatamab (JNJ-63898081), an IgG4 bispecific antibody targeting PSMA and CD3, demonstrates anti-cancer efficacy in prostate cancer research [1].Forma y color:LiquidUbamatamab
CAS:Ubamatamab (REGN4018), a human bispecific antibody targeting Mucin 16 (MUC16) and CD3, exhibits potent antitumor activity [1].Pureza:95%Forma y color:LiquidTepoditamab
CAS:Tepoditamab (MCLA-117) is a bispecific antibody targeting CLEC12A and CD3, inducing T cell lysis of AML cells.Forma y color:LiquidFlotetuzumab
CAS:Flotetuzumab (MGD006/S80880) is a CD123/CD3 bispecific DART antibody, reactivating T-cells for AML treatment.Forma y color:LiquidAcapatamab
CAS:Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. It exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. This compound is utilized in cancer research.Forma y color:LiquidVatelizumab
CAS:Vatelizumab is a humanised monoclonal antibody targeting Integrin α2β1 ( VLA-2, CD49b), which enhances the frequency of regulatory T cells multiple sclerosis.Pureza:95%Forma y color:LiquidPeso molecular:~150 kDaObrindatamab
CAS:Obrindatamab: a humanized bispecific antibody targeting B7-H3/CD3, enhances CTL-mediated cancer cell killing.Forma y color:LiquidAnti-Mouse TCR γ/δ Antibody (UC7-13D5)
Anti-Mouse TCR gamma/delta Antibody is a host Armenian Hamster-derived IgG class inhibitor targeting the mouse TCR gamma/delta receptor.Forma y color:Odour LiquidVibecotamab
CAS:Vibecotamab, a bispecific antibody, targets CD123/CD3 for T-cell killing of tumors, promising for acute myeloid leukemia.Forma y color:LiquidAnti-Mouse CD3ε Antibody (145-2C11)
Anti-Mouse CD3ε Antibody (145-2C11) is an antibody inhibitor targeting CD3ε in Armenian hamsters, in TCR formation and in T lymphocyte activationPureza:99%Forma y color:Odour LiquidPeso molecular:150 kDaVonsetamig
CAS:Vonsetamig, a humanized immunoglobulin G4-kappa monoclonal antibody, targets both TNFRSF17 and CD3E. It serves as an antineoplastic agent.Forma y color:LiquidRovelizumab
CAS:Rovelizumab, Humanized anti-CD11/CD18 mAb, inhibits overactive leukocytes during shock, for MS, hemorrhagic shock, myocardial infarction, and stroke.Pureza:95% - 95%Forma y color:LiquidEnlimomab
CAS:Enlimomab (BI-RR 0001), a mouse IgG2a antibody, blocks leukocyte binding to ICAM-1, reducing inflammation and used in stroke research.Forma y color:LiquidAlnuctamab
CAS:Alnuctamab (EM901) is a humanized, asymmetric two-arm IgG T-cell engager (TCE) with potential applications in immunological research [1].Forma y color:LiquidPacanalotamab
CAS:Pacanalotamab (AMG 420/BI-836909), a BiTE, directs T-cells to BCMA+ MM cells, causing lysis.Forma y color:Liquid
