Integrin
Los inhibidores de integrinas se dirigen a las integrinas, una familia de receptores en la superficie celular que desempeñan un papel crucial en la adhesión celular, la migración y la transducción de señales. Las integrinas están involucradas en la regulación del ciclo celular, particularmente en procesos como la división y la diferenciación celular. Inhibir las integrinas puede interrumpir estos procesos, lo que lleva al arresto del ciclo celular y la apoptosis, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer y el estudio de la metástasis. En CymitQuimica, ofrecemos una amplia gama de inhibidores de integrinas de alta calidad para apoyar su investigación en la regulación del ciclo celular, la biología del cáncer y el desarrollo terapéutico.
Se han encontrado 278 productos de "Integrin"
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TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Fórmula:C37H50F2N12O13Forma y color:SolidPeso molecular:908.86K34c hydrochloride
CAS:K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.Fórmula:C26H30ClN3O4Pureza:99.76% - 99.89%Forma y color:SoildPeso molecular:483.99Lamifiban trifluoroacetate
CAS:Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa).Fórmula:C26H29F3N4O8Forma y color:SolidPeso molecular:582.533Fradafiban hydrochloride
Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.Fórmula:C20H22ClN3O4Forma y color:SolidPeso molecular:403.86Ganodermaones B
Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .Fórmula:C21H26O5Forma y color:SolidPeso molecular:358.43LDV-FITC TFA
LDV-FITC TFA is a fluorescent peptide, specifically an FITC-conjugated LDV peptide. This compound binds to the α4β1 integrin with high affinity, displaying a Kd of 0.3 nM in the presence of Mn2+ and 12 nM in its absence, when binding to U937 cells. LDV-FITC TFA is useful for assessing α4β1 integrin affinity.Fórmula:C69H81N11O17S·xC2HF3O2Fibronectin CS1 Peptide
CAS:Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.Fórmula:C38H64N8O15Pureza:98%Forma y color:SolidPeso molecular:872.96GRGDSPK TFA
GRGDSPK TFA is an RGD peptide, competitive inhibitor of integrin-fibronectin, used to research integrins in bone dynamics.Fórmula:C30H50F3N11O13Forma y color:SolidPeso molecular:829.78αvβ5 integrin-IN-1
CAS:αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.Fórmula:C25H28F3N3O3Forma y color:SolidPeso molecular:475.512LDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Fórmula:C48H70N10O12Pureza:98%Forma y color:SolidPeso molecular:979.13Integrin Binding Peptide
CAS:Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.Fórmula:C42H63N15O16SForma y color:SolidPeso molecular:1066.12PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Fórmula:C17H12F3NO2Forma y color:SolidPeso molecular:319.278α2β1 Integrin Ligand Peptide TFA
α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is aFórmula:C16H23F3N4O11Pureza:98%Forma y color:SolidPeso molecular:504.37MORF-627
CAS:MORF-627 is an orally active selective inhibitor of integrin αvβ6 (integrinαvβ6), with an IC50 of 9.2 nM as measured in a human serum ligand binding assay. It effectively inhibits αvβ6-mediated activation of TGF-β1 with an IC50 of 2.63 nM and suppresses SMAD2/3 phosphorylation, showing an IC50 of 8.3 nM. Additionally, MORF-627 ameliorates bleomycin-induced pulmonary fibrosis in mice.Fórmula:C31H40FN3O4Forma y color:SolidPeso molecular:537.67Echistatin TFA
Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.Forma y color:Odour SolidSMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Fórmula:C20H21NO5Pureza:98.29%Forma y color:SoildPeso molecular:355.38MS133
MS133 is a human bispecific antibody targeting CD133/PROM1 and CD3E. It is used in the study of colon cancer.Forma y color:Odour LiquidBIO5192 hydrate
BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.Forma y color:SolidOrbofiban acetate
CAS:Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administeredFórmula:C19H27N5O6Forma y color:SolidPeso molecular:421.45AB-3PRGD2
CAS:AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.Fórmula:C137H215IN30O45SForma y color:SolidPeso molecular:3161.32
