CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Se han encontrado 526 productos de "CDK"
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Roccellic Acid
CAS:Roccellic acid from R. montagnei lichen has antibacterial, anticancer properties; MIC 46.9 μg/ml; inhibits cancer cells by up to 87.9%.Fórmula:C17H32O4Forma y color:SolidPeso molecular:300.43CDK7-IN-21
CAS:<p>CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .</p>Fórmula:C33H36FN9O2Forma y color:SolidPeso molecular:609.7dCeMM3
CAS:<p>dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.</p>Fórmula:C14H11ClN4OSPureza:98.48% - 99.41%Forma y color:SolidPeso molecular:318.78WAY-322243
CAS:WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Fórmula:C18H18N2O2SPureza:99.88%Forma y color:SoildPeso molecular:326.41WAY-647802
CAS:<p>WAY-647802 is a CDK inhibitor.</p>Fórmula:C11H14N4O3Pureza:99.53%Forma y color:SolidPeso molecular:250.25CDK12-IN-2
CAS:<p>CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.</p>Fórmula:C32H32N6O2Pureza:99.31%Forma y color:SolidPeso molecular:532.64PROTAC FLT3/CDKs degrader-1
<p>PROTACFLT3/CDKs degrader-1 (Compound C3) is an agent that degrades cyclin-dependent kinase (CDK2 with a DC50 of 18.73 nM) and FMS-like tyrosine kinase 3 (FLT3). It induces differentiation in HL-60 cells, achieving a 72.77% differentiation rate at 6.25 nM, and inhibits proliferation of acute myeloid leukemia (AML) cells, with an IC50 ranging from 2.9 to 37 nM. PROTACFLT3/CDKs degrader-1 demonstrates potential for improving the treatment of AML.</p>Fórmula:C40H42N12O5Peso molecular:770.34011CDK7-IN-7
CAS:<p>CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).</p>Fórmula:C20H20BrF3N6O2Forma y color:SolidPeso molecular:513.319CDK9 inhibitor HH1
CAS:<p>CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.</p>Fórmula:C13H15N3OSPureza:99.92%Forma y color:SolidPeso molecular:261.34IV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Fórmula:C23H32FN5O2SiForma y color:SolidPeso molecular:457.625PROTAC CDK9/CycT1 Degrader-2
<p>PROTAC CDK9/CycT1 Degrader-2 inhibits CDK9 with an IC50 of 45 nM [1].</p>Fórmula:C30H36N4O6S2Pureza:98%Forma y color:SolidPeso molecular:612.76Multi-target kinase inhibitor 2
Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 valuesPureza:98%Forma y color:Odour SolidTMX-2039
CAS:TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Fórmula:C17H20BrFN6O3SForma y color:SolidPeso molecular:487.347CDK2/PIM1-IN-1
<p>CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.</p>Forma y color:Odour SolidCDK8/19-IN-3
<p>CDK8/19-IN-3 (compound 3-7) is a potent and selective inhibitor of CDK8 and CDK19. It can increase IL-10 levels and has potential for research in inflammatory bowel disease (IBD).</p>Fórmula:C20H23FN6O2Forma y color:SolidPeso molecular:398.434CDK12-Cyclin K Ligand-Linker Conjugates 1
CDK12-Cyclin K Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate that includes a CDK12-Cyclin K ligand and a PROTAC linker, which can recruit E3 ligase. CDK12-Cyclin K Ligand-Linker Conjugates 1 is applicable for the synthesis of PROTACPP-C8.Forma y color:Odour SolidPROTAC CDK9 degrader-6
CAS:PROTAC CDK9 degrader-6 targets and degrades CDK9 isoforms via proteasome, with DC50 of 0.10μM and 0.14μM.Fórmula:C42H49Cl2N9O8Pureza:98%Forma y color:SolidPeso molecular:878.8CDK-IN-12
CAS:CDK-IN-12 (Example 20), a CDK inhibitor, effectively inhibits CDK4/6, demonstrating IC50 values below 20 nM [1].Fórmula:C26H29FN6OSForma y color:SolidPeso molecular:492.61CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Fórmula:C24H22FN7O2Forma y color:SolidPeso molecular:459.48CDK2/4-IN-1
CDK2/4-IN-1 (compound B-4a) serves as both a CDK2/4 inhibitor and a microtubule polymerization inhibitor, making it useful in cancer research.Forma y color:Odour SolidCDK7-IN-2 hydrochloride hydrate
CAS:CDK7-IN-2 HCl hydrate is a potent, specific CDK7 enzyme inhibitor with significant anti-cancer effects.Fórmula:C26H42ClN7O4Forma y color:SolidPeso molecular:552.12Olomoucine
CAS:<p>Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.</p>Fórmula:C15H18N6OPureza:99.77%Forma y color:White Crystalline PowderPeso molecular:298.34FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Forma y color:LiquidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidCDK-IN-15
CAS:CDK-IN-15 (Compound 456) is an effective inhibitor of Cyclin A, exhibiting an IC50 value of 0.14 μM.Fórmula:C45H63Cl2F4N7O8Forma y color:SolidPeso molecular:976.92YX-2-107
CAS:YX-2-107: CDK6-degrading PROTAC, IC50 of 4.4 nM, hinders RB phosphorylation/FOXM1, counters Ph+ ALL growth in rats, targets Ph+ ALL prophylaxis/treatment.Fórmula:C45H51N11O9Pureza:98.09% - 99.148%Forma y color:SolidPeso molecular:889.95CDK2-IN-7
CAS:CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).Fórmula:C24H30N6O4SForma y color:SolidPeso molecular:498.6CDK-TCIP2
DK-TCIP2 is an anticancer agent formed by linking the CDK9 inhibitor SNS-032 and the BCL6 inhibitor BI-3812. This compound exhibits anticancer activity both in vivo and in vitro, making it suitable for research in lymphoma.Fórmula:C52H67ClN12O8S2Forma y color:SolidPeso molecular:1087.75PROTAC CDK9 degrader 4
CAS:PROTAC CDK9 degrader 4 is a CDK9 degrader that targets transcriptional regulation and has potential anticancer activity.Fórmula:C43H56N10O5Forma y color:SolidPeso molecular:792.97CDK9-IN-35
<p>CDK9-IN-35 (compound 10j) acts as an inhibitor of CDK9/CyclinT1, exhibiting an IC50 of 10.2 nM. It also shows an IC50 of 20 nM against the HCT-116 cell line.</p>Fórmula:C26H24ClFN4O4SForma y color:SolidPeso molecular:543.01CDK1-IN-2
CAS:CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Fórmula:C17H11ClN2OPureza:98.53%Forma y color:SoildPeso molecular:294.73Cell Cycle Compound Library
<p>A unique collection of xnum cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Forma y color:Odour SolidCDK6/9-IN-1
CAS:<p>CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).</p>Fórmula:C22H25ClN8OForma y color:SolidPeso molecular:452.95Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Fórmula:C21H20ClNO5Pureza:97.74% - 99.99%Forma y color:SolidPeso molecular:401.84PP-C8
PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.Fórmula:C43H51FN12O7Forma y color:SolidPeso molecular:866.94JH-XVI-178
CAS:JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Fórmula:C22H22ClN7OForma y color:SolidPeso molecular:435.923MB-PP1
CAS:3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Fórmula:C17H21N5Pureza:99.96%Forma y color:White SolidPeso molecular:295.38HS-243
CAS:<p>HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.</p>Fórmula:C17H16N4O3Pureza:98.62%Forma y color:SolidPeso molecular:324.33NCT02
CAS:NCT02 degrades cyclin K, leading to CCNK and CDK12 degradation, potentially aiding metastatic CRC research.Fórmula:C17H16N2O2SForma y color:SolidPeso molecular:312.39CDK5-IN-3
CAS:CDK5-IN-3 is a selective and potent CDK5 inhibitor that inhibits CDK5/p25 and CDK2/CycA, and can be used in the study of cancer.Fórmula:C22H26N4OPureza:98.21%Forma y color:SolidPeso molecular:362.47Palbociclib-d8
CAS:Palbociclib-d8 (PD 0332991 D8) is the deuterated form of Palbociclib. Palbociclib is a CDK inhibitor that inhibits CDK4 and CDK6.Fórmula:C24H21D8N7O2Pureza:98%Forma y color:SolidPeso molecular:455.58SB1317
CAS:SB1317 (TG02) is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).Fórmula:C23H24N4OPureza:99.86%Forma y color:SolidPeso molecular:372.46TG003
CAS:TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Fórmula:C13H15NO2SPureza:99.46%Forma y color:SolidPeso molecular:249.33GP-82996
CAS:GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.Fórmula:C27H32N6OPureza:99.94%Forma y color:SolidPeso molecular:456.58(E/Z)-Zotiraciclib hydrochloride
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent inhibitor of CDK2, JAK2, and FLT3.Fórmula:C23H25ClN4OForma y color:SolidPeso molecular:408.93LDC4297
CAS:LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.Fórmula:C23H28N8OPureza:98.25%Forma y color:SolidPeso molecular:432.52Ribociclib hydrochloride
CAS:Ribociclib hydrochloride (LEE011 HCl) is a selective, orally active cyclin-dependent kinase CDK4/6 inhibitor (IC50=10/39 nM) that inhibits proliferation.Fórmula:C23H31ClN8OPureza:99.87%Forma y color:SolidPeso molecular:471NU6102
CAS:NU6102 is a CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer.Fórmula:C18H22N6O3SPureza:99.76%Forma y color:SolidPeso molecular:402.47Palbociclib hydrochloride
CAS:Palbociclib hydrochloride is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor for breast and hepatocellular carcinoma.Fórmula:C24H31Cl2N7O2Pureza:99.89%Forma y color:SolidPeso molecular:520.46FMF-04-159-2
CAS:FMF-04-159-2 is a potent covalent CDK14 & CDK2 inhibito and is able to reduce α-Syn aggregation in neurons, and inhibits TNBC cancer progression.Fórmula:C28H30Cl3N7O5SPureza:96.57%Forma y color:SolidPeso molecular:683.01Ribociclib-d6
CAS:Ribociclib-d6 is a deuterated compound of Ribociclib (LEE011) for isotope tracing.Ribociclib is an orally available CDK4/6 inhibitor with antitumor activity.Fórmula:C23H30N8OForma y color:SolidPeso molecular:440.57CDK9-IN-1
CAS:CDK9-IN-1 is a selective and potent CDK9 inhibitor with antiviral activity used in the study of PRRSV infections.Fórmula:C26H21N5O4SPureza:98.52%Forma y color:SolidPeso molecular:499.54Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Fórmula:C25H31ClN6O2Forma y color:SolidPeso molecular:483.011-NM-PP1
CAS:1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.Fórmula:C20H21N5Pureza:98% - 98.93%Forma y color:White Cyrstalline SolidPeso molecular:331.41Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Fórmula:C18H18FN5O2SPureza:98.8%Forma y color:SolidPeso molecular:387.43DRB
CAS:<p>DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)</p>Fórmula:C12H12Cl2N2O4Pureza:99.46% - 99.83%Forma y color:White To Off-White Crystalline SolidPeso molecular:319.14PHA-767491 hydrochloride
CAS:PHA-767491 (CAY-10572) is a potent Cdc7/CDK9 inhibitor (IC50: 10/34 nM), selective against GSK3-β, CDK1/2, CDK5, MK2, CHK2, PLK1.Fórmula:C12H12ClN3OPureza:99.56% - 99.92%Forma y color:SolidPeso molecular:249.69Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Fórmula:C55H103N15O14Pureza:96.21%Forma y color:SolidPeso molecular:1198.5PF-06873600
CAS:PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Fórmula:C20H27F2N5O4SPureza:98.77% - 99.55%Forma y color:SolidPeso molecular:471.52AMG 925 HCl
CAS:AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM).Fórmula:C26H30ClN7O2Forma y color:SolidPeso molecular:508.02CDK9-IN-30
CAS:CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.Fórmula:C16H20FNO3Pureza:99.75%Forma y color:SolidPeso molecular:293.33AZD-5438
CAS:AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).Fórmula:C18H21N5O2SPureza:99.73% - 99.87%Forma y color:SolidPeso molecular:371.46Flavopiridol hydrochloride
CAS:Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.Fórmula:C21H21Cl2NO5Pureza:98.87% - 99.88%Forma y color:SolidPeso molecular:438.3AG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Fórmula:C16H12N2O3Pureza:98.69%Forma y color:SolidPeso molecular:280.28Seliciclib
CAS:Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Fórmula:C19H26N6OPureza:97.15% - 99.89%Forma y color:White To Off-White SolidPeso molecular:354.45Bromosporine
CAS:Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.Fórmula:C17H20N6O4SPureza:99.65% - 99.79%Forma y color:SolidPeso molecular:404.44BSJ-03-123
CAS:BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.Fórmula:C47H56N10O11Pureza:97.78% - 99.38%Forma y color:SolidPeso molecular:937.01(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Fórmula:C23H24N4OPureza:97.75% - 99.92%Forma y color:SolidPeso molecular:372.46PF-562271 besylate
CAS:PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Fórmula:C21H20F3N7O3S·C6H6O3SPureza:97.65% - 99.01%Forma y color:SolidPeso molecular:665.66Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Fórmula:C16H11N3O2Pureza:99.55%Forma y color:Dark Red SolidPeso molecular:277.28JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Fórmula:C24H33ClN6O2SPureza:99.96% - 99.96%Forma y color:SolidPeso molecular:505.08THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Fórmula:C31H29Cl2N7O2Forma y color:SolidPeso molecular:602.51Dinaciclib
CAS:Dinaciclib (SCH 727965) is a CDK inhibitor that selectively inhibits CDK1, CDK2, CDK5, and CDK9 (IC50 = 3/1/1/4 nM).Fórmula:C21H28N6O2Pureza:98.21% - 99.75%Forma y color:SolidPeso molecular:396.49LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Fórmula:C16H12FN5OForma y color:SolidPeso molecular:309.37BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Fórmula:C16H10BrN3O2Pureza:99.67%Forma y color:SolidPeso molecular:356.17PF-562271
CAS:PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Fórmula:C21H20F3N7O3SPureza:97.17% - >99.99%Forma y color:SolidPeso molecular:507.49BS-181 dihydrochloride
CAS:BS-181 dihydrochloride: Potent CDK7 inhibitor (IC50: 21 nM), less effective on CDK2/5/9, no impact on CDK1/4/6, halts cancer cell growth, triggers apoptosis.Fórmula:C22H34Cl2N6Forma y color:SolidPeso molecular:453.46THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Fórmula:C31H28ClN7O2Pureza:97.42% - 99.27%Forma y color:SolidPeso molecular:566.05PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Fórmula:C12H11N3OPureza:99.49% - >99.99%Forma y color:SolidPeso molecular:213.24RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:98% - 99.91%Forma y color:SolidPeso molecular:545.63CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H14Cl3N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:358.67AT7519 Hydrochloride
CAS:AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.Fórmula:C16H18Cl3N5O2Pureza:99.66% - 99.9%Forma y color:SolidPeso molecular:418.71SR-4835
CAS:SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Fórmula:C21H20Cl2N10OPureza:98.09% - >99.99%Forma y color:SolidPeso molecular:499.36BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Fórmula:C18H17F2N3O2Pureza:99.25% - 99.57%Forma y color:SolidPeso molecular:345.34LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Fórmula:C26H39N7O3Pureza:99.66%Forma y color:SolidPeso molecular:497.63HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Fórmula:C15H15N5OS2Pureza:98.11%Forma y color:SolidPeso molecular:345.44KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Forma y color:SolidPeso molecular:360.33Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Fórmula:C21H31N7OPureza:99.75%Forma y color:SolidPeso molecular:397.522-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Fórmula:C4H3ClN2Pureza:98.98% - 99.89%Forma y color:Clear Colorless To Yellowish LiquidPeso molecular:114.53MSC2530818
CAS:MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).Fórmula:C18H17ClN4OPureza:98.93%Forma y color:SolidPeso molecular:340.81Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Fórmula:C32H44O8Pureza:98.88% - 99.87%Forma y color:SolidPeso molecular:556.69Amantadine
CAS:<p>Amantadine (1-Aminoadamantane), an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release and blocks dopamine reuptake.</p>Fórmula:C10H17NPureza:99.73% - 99.94%Forma y color:Hexakistetrahedral Crystals By Sublimation SolidPeso molecular:151.25NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Fórmula:C16H19ClN6OPureza:98% - 99.34%Forma y color:SolidPeso molecular:346.81Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFórmula:C15H10O5Pureza:97.93%Forma y color:SolidPeso molecular:270.24Dalpiciclib
CAS:<p>Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.</p>Fórmula:C25H30N6O2Pureza:99.69%Forma y color:SolidPeso molecular:446.54SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Fórmula:C15H18BrN7Pureza:99.88%Forma y color:SolidPeso molecular:376.25BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Fórmula:C16H17N5Pureza:90%Forma y color:SolidPeso molecular:279.34CC-671
CAS:CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Fórmula:C28H28N6O4Pureza:98.66% - 98.8%Forma y color:SolidPeso molecular:512.56NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Fórmula:C17H19Cl2N5O4SPureza:99.56% - 99.85%Forma y color:SolidPeso molecular:460.33
