CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Se han encontrado 546 productos de "CDK"
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TG-693
CAS:TG-693, Oral CLK1 inhibitor, promotes exon 31 skipping of dystrophin gene, inhibits CLK1 substrate phosphorylation, for Duchenne muscular dystrophy.Fórmula:C12H9N3Pureza:99.81%Forma y color:SolidPeso molecular:195.23Palbociclib hydrochloride
CAS:Palbociclib hydrochloride is the salt form of Palbociclib, a selective and orally available CDK4 and CDK6 inhibitor for breast and hepatocellular carcinoma.Fórmula:C24H31Cl2N7O2Pureza:99.89%Forma y color:SolidPeso molecular:520.46FMF-04-159-2
CAS:FMF-04-159-2 is a potent covalent CDK14 & CDK2 inhibito and is able to reduce α-Syn aggregation in neurons, and inhibits TNBC cancer progression.Fórmula:C28H30Cl3N7O5SPureza:96.57%Forma y color:SolidPeso molecular:683.01Ribociclib-d6
CAS:Ribociclib-d6 is a deuterated compound of Ribociclib (LEE011) for isotope tracing.Ribociclib is an orally available CDK4/6 inhibitor with antitumor activity.Fórmula:C23H30N8OForma y color:SolidPeso molecular:440.57NCT02
CAS:NCT02 degrades cyclin K, leading to CCNK and CDK12 degradation, potentially aiding metastatic CRC research.Fórmula:C17H16N2O2SForma y color:SolidPeso molecular:312.39CDK9-IN-1
CAS:CDK9-IN-1 is a selective and potent CDK9 inhibitor with antiviral activity used in the study of PRRSV infections.Fórmula:C26H21N5O4SPureza:98.52%Forma y color:SolidPeso molecular:499.54PROTAC CDK9 Degrader-1
CAS:PROTAC CDK9 Degrader-1 is a selective PROTAC-based CDK9 degrader, composed of a Cereblon ligand and a CDK ligand.Fórmula:C33H35N5O7Pureza:95.1%Forma y color:SolidPeso molecular:613.66Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Fórmula:C18H18FN5O2SPureza:98.8%Forma y color:SolidPeso molecular:387.43Ref: TM-T10464L
1mg84,00€2mg114,00€5mg192,00€10mg313,00€25mg580,00€50mg773,00€100mg1.063,00€1mL*10mM (DMSO)212,00€BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Fórmula:C18H17F2N3O2Pureza:99.25% - 99.57%Forma y color:SolidPeso molecular:345.34Ref: TM-T2679
1mg34,00€5mg71,00€10mg110,00€25mg210,00€50mg318,00€100mg455,00€200mg617,00€1mL*10mM (DMSO)78,00€DRB
CAS:DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)
Fórmula:C12H12Cl2N2O4Pureza:99.46% - 99.83%Forma y color:White To Off-White Crystalline SolidPeso molecular:319.14Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Fórmula:C25H31ClN6O2Forma y color:SolidPeso molecular:483.01HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Fórmula:C15H15N5OS2Pureza:98.11%Forma y color:SolidPeso molecular:345.44Ref: TM-T9849
1mg43,00€2mg56,00€5mg93,00€10mg144,00€25mg319,00€50mg537,00€100mg767,00€500mg1.558,00€1mL*10mM (DMSO)90,00€Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Fórmula:C55H103N15O14Pureza:96.21%Forma y color:SolidPeso molecular:1198.5PF-06873600
CAS:PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Fórmula:C20H27F2N5O4SPureza:98.77% - 99.55%Forma y color:SolidPeso molecular:471.52Ref: TM-T8463
1mg54,00€5mg114,00€10mg178,00€25mg334,00€50mg557,00€100mg888,00€200mg1.198,00€1mL*10mM (DMSO)118,00€AMG 925 HCl
CAS:AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM).Fórmula:C26H30ClN7O2Forma y color:SolidPeso molecular:508.02KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Forma y color:SolidPeso molecular:360.33Ref: TM-T9446
1mg96,00€2mg143,00€5mg235,00€10mg378,00€25mg630,00€50mg898,00€100mg1.216,00€1mL*10mM (DMSO)249,00€CDK9-IN-30
CAS:CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.Fórmula:C16H20FNO3Pureza:99.75%Forma y color:SolidPeso molecular:293.33Ref: TM-T9632
1mg56,00€5mg119,00€10mg187,00€25mg316,00€50mg472,00€100mg658,00€500mg1.378,00€1mL*10mM (DMSO)114,00€AZD-5438
CAS:AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).Fórmula:C18H21N5O2SPureza:99.73% - 99.87%Forma y color:SolidPeso molecular:371.46Flavopiridol hydrochloride
CAS:Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.Fórmula:C21H21Cl2NO5Pureza:98.87% - 99.88%Forma y color:SolidPeso molecular:438.3AT7519 Hydrochloride
CAS:AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.Fórmula:C16H18Cl3N5O2Pureza:99.66% - 99.9%Forma y color:SolidPeso molecular:418.71
