Asociado a microtúbulos
Los inhibidores de proteínas asociadas a microtúbulos se dirigen a proteínas que interactúan con los microtúbulos, los componentes estructurales del citoesqueleto de la célula, esenciales para la división celular. Estas proteínas regulan la estabilidad y la dinámica de los microtúbulos durante la mitosis. Inhibir las proteínas asociadas a microtúbulos puede interrumpir la función de los microtúbulos, lo que lleva al arresto del ciclo celular y la apoptosis, particularmente en células cancerosas de rápida división. Estos inhibidores se utilizan ampliamente en la investigación del cáncer y el desarrollo de fármacos. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteínas asociadas a microtúbulos de alta calidad para apoyar su investigación en división celular, dinámica del citoesqueleto y terapia contra el cáncer.
Se han encontrado 286 productos para "Asociado a microtúbulos".
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Myoseverin B
CAS:Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.Fórmula:C27H32N6O2Forma y color:SolidPeso molecular:472.582Tubulin polymerization-IN-33
Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.Fórmula:C27H28N2O6Forma y color:SolidPeso molecular:476.52Symplostatin 1
CAS:Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides.Fórmula:C43H70N6O6SForma y color:SolidPeso molecular:799.12Antitubulin agent 1
Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.Fórmula:C21H19N3O3Forma y color:SolidPeso molecular:361.39Utrophin modulator 1
UM1 upregulates utrophin, has EC50 of 0.11 μM, useful in DMD research.Fórmula:C22H18N6OForma y color:SolidPeso molecular:382.42Epothilone E
CAS:Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumorFórmula:C26H39NO7SForma y color:SolidPeso molecular:509.66Sagopilone
CAS:Sagopilone: synthetic epothilone, inhibits cell division and induces apoptosis, effective in MDR tumors, not P-gp substrate.Fórmula:C30H41NO6SForma y color:SolidPeso molecular:543.71Alfalone
CAS:Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.Fórmula:C17H14O5Forma y color:SolidPeso molecular:298.29BP-M345
CAS:BP-M345 (compound 5) serves as a powerful antiproliferative agent that selectively targets cancer cells while demonstrating minimal toxicity to non-tumor cells. It effectively inhibits cancer cell proliferation, achieving a GI 50 value between 0.17 to 0.45 μM [1].Fórmula:C25H28O8Forma y color:SolidPeso molecular:456.49Anti-melanoma agent 3
CAS:Compound 5cb, known as Anti-melanoma agent 3, is a derivative of 2-aryl-4-benzoyl-imidazole (ABI) that acts as an inhibitor of melanoma xenogeneic tumors. It exhibits anticancer effects by targeting the colchicine binding site, thereby preventing tubulin polymerization [1].Fórmula:C17H13FN2O2Forma y color:SolidPeso molecular:296.3AMXI-5001 hydrochloride
AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.Fórmula:C25H21ClFN5O3Forma y color:SolidPeso molecular:493.92TTBK1/2-IN-1
CAS:TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.Fórmula:C17H16N4OForma y color:SolidPeso molecular:292.335Tubulin polymerization-IN-35
Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.Fórmula:C31H35N3O5Forma y color:SolidPeso molecular:529.63Dictyostatin
CAS:Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.Fórmula:C32H52O6Forma y color:SolidPeso molecular:532.75Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Fórmula:C31H35N3O6Forma y color:SolidPeso molecular:545.63AMG28
CAS:AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.Fórmula:C20H20N4OForma y color:SolidPeso molecular:332.399TPI-287
CAS:TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.Fórmula:C46H63NO15Forma y color:SolidPeso molecular:869.99Carba1
CAS:Carba1 is a bifunctional carbazole derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances the biosynthesis of NAD. It binds to the colchicine site on tubulin, potentially boosting the antitumor effects of various chemotherapeutics such as Paclitaxel. Carba1 has neuroprotective properties and regulates cellular energy metabolism. It is applicable in research on cancer and chemotherapy-induced peripheral neuropathy (CIPN).Fórmula:C18H15ClN2Peso molecular:294.78Tubulin polymerization-IN-32
Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.Fórmula:C29H30N2O7Forma y color:SolidPeso molecular:518.56ON 01500
CAS:ON 01500 is a tubulin inhibitor with a dissociation constant (Kd) of 21 nM. It acts by depolymerizing microtubules within cells and is utilized in cancer research.Fórmula:C19H23NO6SPeso molecular:393.45
