c-Myc
Los inhibidores de c-Myc se dirigen a la proteína c-Myc, un factor de transcripción que juega un papel crucial en el crecimiento celular, la proliferación y la apoptosis. c-Myc regula la expresión de numerosos genes involucrados en el ciclo celular y a menudo está sobreexpresado en varios tipos de cáncer, lo que lleva a una proliferación celular descontrolada y al crecimiento tumoral. Inhibir c-Myc puede interrumpir estos procesos, induciendo el arresto del ciclo celular y la apoptosis en células cancerosas. Los inhibidores de c-Myc son herramientas importantes en la investigación del cáncer y el desarrollo terapéutico. En CymitQuimica, ofrecemos una amplia gama de inhibidores de c-Myc de alta calidad para apoyar su investigación en oncología, regulación del ciclo celular y control transcripcional.
Se han encontrado 77 productos de "c-Myc"
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Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Fórmula:C13H20N2O6Forma y color:SolidPeso molecular:300.308c-Myc inhibitor 7
CAS:c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.Fórmula:C35H30N6O5Forma y color:SoildPeso molecular:614.65MYC-IN-2
CAS:MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Fórmula:C25H17N3O2SForma y color:SolidPeso molecular:423.49Anticancer agent 84
CAS:Anticancer agent 84 inhibits c-MYC transcription by stabilizing G4 structures, aiding cancer research.Fórmula:C57H67N7O9Forma y color:SolidPeso molecular:994.18VGN50
VGN50 is a bioactive molecule that mimics the function of K-Rta, capable of downregulating MYC-mediated gene transcription. VGN50 exhibits antitumor activity.Fórmula:C121H218N46O32Peso molecular:2827.68453c-Myc inhibitor 13
c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.Fórmula:C30H39N9OPeso molecular:541.32776CSI86
CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).Fórmula:C48H50F9N7O7SForma y color:SolidPeso molecular:1040Cotylenin A
CAS:Cotylenin A is a phenanthraquinone compound that synergistically works with vitamin K2 to induce monocyte differentiation and growth arrest. It also inhibits c-Myc expression while inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A is applicable in acute myeloid leukemia research.Fórmula:C33H50O11Forma y color:SolidPeso molecular:622.744H122
H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Fórmula:C45H45ClFN5O8Forma y color:SolidPeso molecular:838.319VPC-70063
CAS:VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Fórmula:C16H12F6N2SPureza:99.98%Forma y color:SolidPeso molecular:378.34Ref: TM-T60019
1mg49,00€5mg101,00€1mL*10mM (DMSO)130,00€10mg152,00€25mg268,00€50mg385,00€100mg560,00€200mg790,00€VTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.Forma y color:Odour LiquidKL4-219A
KL4-219A is a selective covalent degrader of the MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner .Fórmula:C20H22N2O3SPureza:99.68%Forma y color:SolidPeso molecular:370.47PROTAC LZK-IN-1
CAS:PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.
Fórmula:C51H64F2N10O5SForma y color:SolidPeso molecular:967.18c-Myc ligand 1
CAS:c-Mycligand 1 is a c-Myc inhibitor and functions as a ligand for target proteins in PROTAC (Proteolysis Targeting Chimeras). It is utilized in the synthesis of PROTAC c-Myc inhibitor 7.Fórmula:C13H10N2O2Peso molecular:226.23IRES-C11
CAS:IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.Fórmula:C13H11Cl2NO4Pureza:99.89%Forma y color:SolidPeso molecular:316.14Ref: TM-T40419
1mg94,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.674,00€200mg2.242,00€sAJM589
CAS:sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Fórmula:C16H10N2OPureza:98%Forma y color:SolidPeso molecular:246.26(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Fórmula:C20H16N2O5Pureza:99.09% - 99.81%Forma y color:SolidPeso molecular:364.3510074-G5
CAS:10074-G5 is an inhibitor of c-Myc-Max dimerization.Fórmula:C18H12N4O3Pureza:99.51% - 99.94%Forma y color:SolidPeso molecular:332.31Ref: TM-T3686
2mg39,00€5mg59,00€1mL*10mM (DMSO)65,00€10mg84,00€25mg135,00€50mg213,00€100mg375,00€200mg535,00€500mg853,00€ML327
CAS:ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).Fórmula:C19H18N4O4Pureza:98.47%Forma y color:SolidPeso molecular:366.37Ref: TM-T4252
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg137,00€25mg222,00€50mg356,00€100mg612,00€200mg850,00€Saxagliptin
CAS:Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.Fórmula:C18H25N3O2Pureza:99.17% - 99.95%Forma y color:SolidPeso molecular:315.41
